The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis

(2022) Luke A. Perera et al.   Cold Spring Harbor Perspectives in Biology

A secreted effector with a dual role as a toxin and as a transcriptional factor

(2022) Dandan Wang et al.   Nature Communications

PredictProtein - Predicting Protein Structure and Function for 29 Years

(2021) Michael Bernhofer et al.   NUCLEIC ACIDS RESEARCH

Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1)

(2021) Nikolaus Dietz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

(2021) Carter J Barger et al.   eLife

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

(2021) Luke A. Perera et al.   Nature Communications

Conformational control of small GTPases by AMPylation

(2020) Katja Barthelmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factors and DNA Play Hide and Seek

(2020) David M. Suter   TRENDS IN CELL BIOLOGY

SMART: recent updates, new developments and status in 2020

(2020) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Dual conformational recognition by Z-DNA binding protein is important for the B–Z transition process

(2020) Chaehee Park et al.   NUCLEIC ACIDS RESEARCH

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation

(2020) Dorothea Höpfner et al.   iScience

Searching algorithm for Type IV effector proteins (S4TE) 2.0: Improved tools for Type IV effector prediction, analysis and comparison in proteobacteria

(2019) Christophe Noroy et al.   PLoS Computational Biology

A Ca2+-regulated deAMPylation switch in human and bacterial FIC proteins

(2019) Simon Veyron et al.   Nature Communications

An oligomeric state‐dependent switch in the ER enzyme FICD regulates AMP ylation and de AMP ylation of BiP

(2019) Luke A Perera et al.   EMBO JOURNAL

Serine is the major residue for ADP-ribosylation upon DNA damage

(2018) Luca Palazzo et al.   eLife

OUP accepted manuscript

(2018)   NUCLEIC ACIDS RESEARCH

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies

(2017) Amanda K. Casey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine ADP-Ribosylation Depends on HPF1

(2017) Juan José Bonfiglio et al.   MOLECULAR CELL

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

(2016) Carole Eldin et al.   CLINICAL MICROBIOLOGY REVIEWS

A Novel Fic (Filamentation Induced by cAMP) Protein fromClostridium difficileReveals an Inhibitory Motif-independent Adenylylation/AMPylation Mechanism

(2016) Emil Dedic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus

(2016) Maria E. Lund et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Serine is a new target residue for endogenous ADP-ribosylation on histones

(2016) Orsolya Leidecker et al.   Nature Chemical Biology

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

(2016) Steffen Preissler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UniProt: the universal protein knowledgebase

(2016)   NUCLEIC ACIDS RESEARCH

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

(2016) Steffen Preissler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones

(2016) Matthias C. Truttmann et al.   PLoS Genetics

HypE-specific Nanobodies as Tools to Modulate HypE-mediated Target AMPylation

(2015) Matthias C. Truttmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In silico identification of AMPylating enzymes and study of their divergent evolution

(2015) Shradha Khater et al.   Scientific Reports

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

(2015) Steffen Preissler et al.   eLife

MoRDa, an automatic molecular replacement pipeline

(2015) Alexey Vagin et al.   Acta Crystallographica A-Foundation and Advances

Coxiella burnetii Effector Proteins That Localize to the Parasitophorous Vacuole Membrane Promote Intracellular Replication

(2014) Charles L. Larson et al.   INFECTION AND IMMUNITY

Unfolded Protein Response-regulatedDrosophilaFic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis

(2014) Hyeilin Ham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PredictProtein—an open resource for online prediction of protein structural and functional features

(2014) Guy Yachdav et al.   NUCLEIC ACIDS RESEARCH

The many faces of Fic: structural and functional aspects of Fic enzymes

(2014) Abel Garcia-Pino et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein expression, characterization, crystallization and preliminary X-ray crystallographic analysis of a Fic protein fromClostridium difficile

(2014) Ditte Welner et al.   Acta Crystallographica Section F-Structural Biology Communications

Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

(2013) Erin J. van Schaik et al.   NATURE REVIEWS MICROBIOLOGY

Effector Protein Translocation by the Coxiella burnetii Dot/Icm Type IV Secretion System Requires Endocytic Maturation of the Pathogen-Occupied Vacuole

(2013) Hayley J. Newton et al.   PLoS One

Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold

(2013) Arnaud Goepfert et al.   PLoS One

Probing Allostery Through DNA

(2013) S. Kim et al.   SCIENCE

Implementing an X-ray validation pipeline for the Protein Data Bank

(2012) Swanand Gore et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Completion of autobuilt protein models using a database of protein fragments

(2012) Kevin Cowtan   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

One-Step Sequence- and Ligation-Independent Cloning as a Rapid and Versatile Cloning Method for Functional Genomics Studies

(2012) Jae-Yeon Jeong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates

(2012) Daniel M. Lewallen et al.   Molecular BioSystems

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

Coxiella burnetii Induces Apoptosis during Early Stage Infection via a Caspase-Independent Pathway in Human Monocytic THP-1 Cells

(2012) Yan Zhang et al.   PLoS One

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

Dot/Icm Type IVB Secretion System Requirements for Coxiella burnetii Growth in Human Macrophages

(2011) P. A. Beare et al.   mBio

The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication

(2011) Kimberly L. Carey et al.   PLoS Pathogens

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Kinetic and Structural Insights into the Mechanism of AMPylation by VopS Fic Domain

(2010) Phi Luong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of Fic-mediated adenylylation

(2010) Junyu Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Fido, a Novel AMPylation Domain Common to Fic, Doc, and AvrB

(2009) Lisa N. Kinch et al.   PLoS One

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

PDBsum new things

(2008) R. A. Laskowski   NUCLEIC ACIDS RESEARCH

Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 Å resolution

(2008) Debanu Das et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE