FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

Biological Diversity and Molecular Plasticity of FIC Domain Proteins

(2016) Alexander Harms et al.   Annual Review of Microbiology

Protein misfolding in the endoplasmic reticulum as a conduit to human disease

(2016) Miao Wang et al.   NATURE

A Novel Link between Fic (Filamentation Induced by cAMP)-mediated Adenylylation/AMPylation and the Unfolded Protein Response

(2015) Anwesha Sanyal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of Fic proteins

(2015) Craig R. Roy et al.   NATURE REVIEWS MICROBIOLOGY

In silico identification of AMPylating enzymes and study of their divergent evolution

(2015) Shradha Khater et al.   Scientific Reports

Unfolded Protein Response-regulatedDrosophilaFic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis

(2014) Hyeilin Ham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Human, FIC-Domain Containing Protein HYPE and Implications for Its Functions

(2014) Tom D. Bunney et al.   STRUCTURE

The many faces of Fic: structural and functional aspects of Fic enzymes

(2014) Abel Garcia-Pino et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

(2013) Edward Avezov et al.   JOURNAL OF CELL BIOLOGY

The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu

(2013) Daniel Castro-Roa et al.   Nature Chemical Biology

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

(2012) Joseph E. Chambers et al.   JOURNAL OF CELL BIOLOGY

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

De-AMPylation of the Small GTPase Rab1 by the Pathogen Legionella pneumophila

(2011) M. R. Neunuebel et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Kinetic and Structural Insights into the Mechanism of AMPylation by VopS Fic Domain

(2010) Phi Luong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of Fic-mediated adenylylation

(2010) Junyu Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

Structure of the Adenylylation Domain of E. coli Glutamine Synthetase Adenylyl Transferase: Evidence for Gene Duplication and Evolution of a New Active Site

(2009) Yibin Xu et al.   JOURNAL OF MOLECULAR BIOLOGY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

(2008) Kseniya Petrova et al.   EMBO JOURNAL

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE