Cetirizine and Levetiracetam as Inhibitors of Monoacylglycerol Lipase: Investigating Their Repurposing Potential as Novel Osteoarthritic Pain Therapies

Monoacylglycerol Lipase Inhibitor JJKK048 Ameliorates ABCG2 Transporter-Mediated Regorafenib Resistance Induced by Hypoxia in Triple Negative Breast Cancer Cells

(2023) Elena Puris et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibition of Monoacylglycerol Lipase Decreases Angiogenic Features of Endothelial Cells via Release of Tissue Inhibitor of Metalloproteinase-1 from Lung Cancer Cells

(2023) Felix Wittig et al.   Cells

Pristimerin, a triterpene that inhibits monoacylglycerol lipase activity, prevents the development of paclitaxel-induced allodynia in mice

(2022) Altaf Al-Romaiyan et al.   Frontiers in Pharmacology

Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain

(2022) Niyusha Asgharpour-Masouleh et al.   BEHAVIOURAL BRAIN RESEARCH

‘SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models

(2021) Silvia Hayer et al.   ANNALS OF THE RHEUMATIC DISEASES

Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase

(2021) Shivani Jaiswal et al.   ChemMedChem

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases

(2021) Anca Zanfirescu et al.   MOLECULES

The burden of OA-health services and economics

(2021) V.P. Leifer et al.   OSTEOARTHRITIS AND CARTILAGE

Identifying FAAH Inhibitors as New Therapeutic Options for the Treatment of Chronic Pain through Drug Repurposing

(2021) Anca Zanfirescu et al.   Pharmaceuticals

Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis

(2020) Shasha Luo et al.   CHEMICO-BIOLOGICAL INTERACTIONS

An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)

(2020) Giulia Bononi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Histamine, histamine receptors and neuropathic pain relief

(2019) Ilona Obara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic options for targeting inflammatory osteoarthritis pain

(2019) Philip G. Conaghan et al.   Nature Reviews Rheumatology

Mitodepressive, antioxidant, antifungal and anti-inflammatory effects of wild-growing Romanian native Arctium lappa L. ( Asteraceae ) and Veronica persica Poiret ( Plantaginaceae )

(2018) Radu Claudiu Fierascu et al.   FOOD AND CHEMICAL TOXICOLOGY

Design, synthesis, and evaluation of piperazinyl pyrrolidin-2-ones as a novel series of reversible monoacylglycerol lipase inhibitors

(2018) Jumpei Aida et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice

(2017) Anca Zanfirescu et al.   Nutrients

Methods Used to Evaluate Pain Behaviors in Rodents

(2017) Jennifer R. Deuis et al.   Frontiers in Molecular Neuroscience

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

(2016) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Randall Selitto pressure algometry for assessment of bone-related pain in rats

(2015) S. Falk et al.   EUROPEAN JOURNAL OF PAIN

The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents

(2015) Y. S. Sakin et al.   NEUROGASTROENTEROLOGY AND MOTILITY

In vivocharacterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects

(2013) B M Ignatowska-Jankowska et al.   BRITISH JOURNAL OF PHARMACOLOGY

The adverse effects profile of levetiracetam in epilepsy: a more detailed look

(2013) Gashirai K. Mbizvo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Levetiracetam Interacts Synergistically With Nonsteroidal Analgesics and Caffeine to Produce Antihyperalgesia in Rats

(2013) Maja A. Tomić et al.   JOURNAL OF PAIN

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

(2013) H. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Local Peripheral Antihyperalgesic Effect of Levetiracetam and Its Mechanism of Action in an Inflammatory Pain Model

(2012) Radica M. Stepanović-Petrović et al.   ANESTHESIA AND ANALGESIA

The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors

(2012) A Chicca et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model

(2012) Sudeshna Ghosh et al.   LIFE SCIENCES

Physiological roles of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand

(2009) Takayuki Sugiura   BIOFACTORS

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Analgesic Effects Of H1 Receptor Antagonists In The Rat Model Of Formalin-Induced Pain

(2009) Hazem Adel Ashmawi et al.   Revista Brasileira de Anestesiologia