Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase

JZL184, A Monoacylglycerol Lipase Inhibitor, Induces Bone Loss in a Multiple Myeloma Model of Immunocompetent Mice

(2020) Silvia Marino et al.   CALCIFIED TISSUE INTERNATIONAL

Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

(2020) Carlotta Granchi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

(2019) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors

(2019) Giulio Poli et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

(2019) Estefanía Moreno et al.   Frontiers in Pharmacology

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy

(2019) Robert Ramer et al.   Frontiers in Pharmacology

Effect of monoacylglycerol lipase on the tumor growth in endometrial cancer

(2019) Xin Li et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Antitumor Cannabinoid Chemotypes: Structural Insights

(2019) Paula Morales et al.   Frontiers in Pharmacology

New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation

(2019) Leonardo Brunetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Monoacylglycerol lipase inhibitors: Modulators for lipid metabolism in cancer malignancy, neurological and metabolic disorders

(2019) Hui Deng et al.   Acta Pharmaceutica Sinica B

Design, synthesis, molecular modelling and in vitro cytotoxicity analysis of novel carbamate derivatives as inhibitors of Monoacylglycerol lipase

(2018) Simone Lauria et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Insights into the effects of the endocannabinoid system in cancer: a review

(2018) Ana Isabel Fraguas-Sánchez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-tumoural actions of cannabinoids

(2018) Burkhard Hinz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-Proliferative Properties and Proapoptotic Function of New CB2 Selective Cannabinoid Receptor Agonist in Jurkat Leukemia Cells

(2018) Antonella Capozzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2018) Mojgan Aghazadeh Tabrizi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of thiazole-5-carboxylate derivatives as selective inhibition of monoacylglycerol lipase as a target in Cancer

(2018) Md Rahmat Ali et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cannabinoids in cancer treatment: Therapeutic potential and legislation

(2018) Barbara Dariš et al.   Bosnian Journal of Basic Medical Sciences

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors

(2018) Giulia Bononi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of terphenyl-2-methyloxazol-5(4H)-one derivatives as selective reversible MAGL inhibitors

(2017) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis

(2017) Ester Pagano et al.   PHARMACOLOGICAL RESEARCH

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474

(2017) Annelot C. M. van Esbroeck et al.   SCIENCE

Hit to lead optimization of a series of N -[4-(1,3-benzothiazol-2-yl)phenyl]acetamides as monoacylglycerol lipase inhibitors with potential anticancer activity

(2016) Obaid Afzal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

FAAH inhibitors in the limelight, but regrettably

(2016) Christophe Mallet et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors

(2016) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparing the effects of endogenous and synthetic cannabinoid receptor agonists on survival of gastric cancer cells

(2016) A. Ortega et al.   LIFE SCIENCES

Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase

(2016) Anne Kerbrat et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells

(2016) Katrin Winkler et al.   Oncotarget

Monoacylglycerol Lipase: A Novel Potential Therapeutic Target and Prognostic Indicator for Hepatocellular Carcinoma

(2016) Junyong Zhang et al.   Scientific Reports

Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents

(2016) Daniel A. Ladin et al.   Frontiers in Pharmacology

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

(2015) Donatella Fiore et al.   CANCER BIOLOGY & THERAPY

Improved Enzymatic Procedure for the Synthesis of Anandamide andN-Fatty Acylalkanolamine Analogues: A Combination Strategy to Antitumor Activity

(2015) Paula G. Quintana et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors

(2015) Carlotta Granchi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

The Role of Monoacylglycerol Lipase (MAGL) in the Cancer Progress

(2014) Hong Qin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

(2014) Rebecca A. Kohnz et al.   CHEMICAL SOCIETY REVIEWS

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling

(2013) Heikki Käsnänen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

(2012) Laurie Hamtiaux et al.   BMC CANCER

Therapeutic potential of monoacylglycerol lipase inhibitors

(2012) Melinda M. Mulvihill et al.   LIFE SCIENCES

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The endocannabinoid system and cancer: therapeutic implication

(2011) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats

(2011) Martin A Sticht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer

(2011) Lin Ye et al.   CANCER LETTERS

Chronic inflammation, the tumor microenvironment and carcinogenesis

(2011) Tamas A. Gonda et al.   CELL CYCLE

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Interaction of endocannabinoid system and steroid Hormones in the control of colon cancer cell growth

(2011) Maria C. Proto et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism

(2011) Laurie Hamtiaux et al.   PLoS One

Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution

(2011) Céline Schalk-Hihi et al.   PROTEIN SCIENCE

Fatty Acid Amide Hydrolase in Prostate Cancer: Association with Disease Severity and Outcome, CB1 Receptor Expression and Regulation by IL-4

(2010) Lina Thors et al.   PLoS One

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

(2010) Douglas S. Johnson et al.   ACS Medicinal Chemistry Letters

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling

(2009) Geoffray Labar et al.   CHEMBIOCHEM

Inflammation and colorectal cancer

(2009) Sarah Kraus et al.   CURRENT OPINION IN PHARMACOLOGY

CAY10499, a Novel Monoglyceride Lipase Inhibitor Evidenced by an Expeditious MGL Assay

(2008) Giulio G. Muccioli et al.   CHEMBIOCHEM

Inflammation and prostate cancer

(2008) Sonya Vasto et al.   Future Oncology

Expression and function of fatty acid amide hydrolase in prostate cancer

(2008) Michael P. Endsley et al.   INTERNATIONAL JOURNAL OF CANCER

Expression and Secretion of N-acylethanolamine-hydrolysing Acid Amidase in Human Prostate Cancer Cells

(2008) J. Wang et al.   JOURNAL OF BIOCHEMISTRY

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology