The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents

A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment

(2014) M. Serpell et al.   EUROPEAN JOURNAL OF PAIN

Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model

(2014) Wayne B. Anderson et al.   NEUROPHARMACOLOGY

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease

(2013) Francesca Borrelli et al.   BIOCHEMICAL PHARMACOLOGY

Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides

(2013) J. Fichna et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The endocannabinoid system mediates aerobic exercise-induced antinociception in rats

(2013) Giovane Galdino et al.   NEUROPHARMACOLOGY

Systematic review and comparison of pharmacologic therapies for neuropathic pain associated with spinal cord injury

(2013) Sonya Snedecor et al.   Journal of Pain Research

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice

(2012) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain

(2012) Barth Wilsey et al.   JOURNAL OF PAIN

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment

(2012) Josée Guindon et al.   PHARMACOLOGICAL RESEARCH

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

(2011) Lamont Booker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sativex®(tetrahydrocannabinol + cannabidiol), an endocannabinoid system modulator: basic features and main clinical data

(2011) Patrick Vermersch   Expert Review of Neurotherapeutics

Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome

(2011) Banny S. Wong et al.   GASTROENTEROLOGY

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

(2011) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain

(2010) Josée Guindon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients

(2010) T. K. Klooker et al.   NEUROGASTROENTEROLOGY AND MOTILITY

An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy

(2010) Jennifer A. Bestard et al.   Pain Practice

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Evaluation of prevalent phytocannabinoids in the acetic acid model of visceral nociception

(2009) Lamont Booker et al.   DRUG AND ALCOHOL DEPENDENCE

CB1 Receptors Mediate the Analgesic Effects of Cannabinoids on Colorectal Distension-Induced Visceral Pain in Rodents

(2009) M. Brusberg et al.   JOURNAL OF NEUROSCIENCE

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

(2009) Angelo A. Izzo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model

(2008) J Desroches et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects

(2008) A A Izzo et al.   GUT

Pharmacological Evaluation of a Novel Cannabinoid 2 (CB2) Ligand, PF-03550096, In Vitro and In Vivo by Using a Rat Model of Visceral Hypersensitivity

(2008) Akira Kikuchi et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Role of cannabinoid receptors in the control of gastrointestinal motility and perception

(2008) Jean Fioramonti et al.   Expert Review of Gastroenterology & Hepatology

Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

(2006) Leon Chang et al.   BRITISH JOURNAL OF PHARMACOLOGY