Identifying FAAH Inhibitors as New Therapeutic Options for the Treatment of Chronic Pain through Drug Repurposing

The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation

(2021) Fabio Arturo Iannotti et al.   Cells

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors

(2021) Agata Zięba et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endocannabinoid activation of the TRPV1 ion channel is distinct from activation by capsaicin

(2021) Yanxin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases

(2021) Anca Zanfirescu et al.   MOLECULES

High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease

(2020) Katharina Klatt‐Schreiner et al.   MOVEMENT DISORDERS

Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs

(2020) Thomas Murphy et al.   Biomolecules

Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors

(2020) Noëlle van Egmond et al.   Annual Review of Pharmacology and Toxicology

Raloxifene as Treatment for Various Types of Brain Injuries and Neurodegenerative Diseases: A Good Start

(2020) Leo Veenman   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

(2020) Mark E. Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

CB1 allosteric modulators and their therapeutic potential in CNS disorders

(2020) Catharine A. Mielnik et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Revefenacin for the treatment of chronic obstructive pulmonary disease

(2019) Fuyuan Li et al.   Expert Review of Clinical Pharmacology

Microdeletion in a pseudogene identified in a patient with high anandamide concentrations and pain insensitivity

(2019) Abdella M. Habib et al.   BRITISH JOURNAL OF ANAESTHESIA

Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) on a Series of Piperazine-Carboxamides Fatty Acid Amide Hydrolase (FAAH) Inhibitors as a Useful Tool for the Design of New Cannabinoid Ligands

(2019) Lorca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Computational Drug Repurposing Algorithm Targeting TRPA1 Calcium Channel as a Potential Therapeutic Solution for Multiple Sclerosis

(2019) Dragos Paul Mihai et al.   Pharmaceutics

A perspective review on fatty acid amide hydrolase (FAAH) inhibitors as potential therapeutic agents

(2019) Rati Kailash Prasad Tripathi   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of Fatty Acid Amide Hydrolase Improves Depressive-Like Behaviors Independent of Its Peripheral Antinociceptive Effects in a Rat Model of Neuropathic Pain

(2018) Hai-xia Jiang et al.   ANESTHESIA AND ANALGESIA

FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats

(2018) Lisa E. Flannery et al.   BEHAVIOURAL BRAIN RESEARCH

The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain

(2018) Yohanna Eriksson et al.   Cell Death & Disease

Brain activity of anandamide: a rewarding bliss?

(2018) Maria Scherma et al.   ACTA PHARMACOLOGICA SINICA

Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model

(2018) Debnath Bhuniya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Predicting the Binding of Fatty Acid Amide Hydrolase Inhibitors by Free Energy Perturbation

(2018) Arjun Saha et al.   Journal of Chemical Theory and Computation

Animal models of congenital hypoalgesia: Untapped potential for assessing pain-related plasticity

(2018) Clara Monteiro et al.   NEUROSCIENCE LETTERS

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain

(2016) Behnam Ghorbanzadeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry

(2016) Weiqi Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

(2016) Yan Qiu et al.   MOLECULES

Acute Neurologic Disorder from an Inhibitor of Fatty Acid Amide Hydrolase

(2016) Anne Kerbrat et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Tolerability and Pharmacokinetics of FAAH Inhibitor V158866: A Double-Blind, Randomised, Placebo-Controlled Phase I Study in Healthy Volunteers

(2016) Stephen Pawsey et al.   Drugs in research & development

Effects of peripheral FAAH blockade on NTG-induced hyperalgesia—evaluation of URB937 in an animal model of migraine

(2015) R Greco et al.   CEPHALALGIA

Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)

(2015) Mojgan Aghazadeh Tabrizi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational insights into function and inhibition of fatty acid amide hydrolase

(2015) Giulia Palermo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discontinued anxiolytic drugs (2009 – 2014)

(2015) Roberto Mandrioli et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

New ways to boost molecular dynamics simulations

(2015) Elmar Krieger et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Montelukast Attenuates Neuropathic Pain Through Inhibiting p38 Mitogen-Activated Protein Kinase and Nuclear Factor-Kappa B in a Rat Model of Chronic Constriction Injury

(2014) Chenghua Zhou et al.   ANESTHESIA AND ANALGESIA

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

(2014) R J Bluett et al.   Translational Psychiatry

Update on Raloxifene

(2013) Salvatore Gizzo et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

Endocannabinoid system and pain: an introduction

(2013) James J. Burston et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The effects of anandamide signaling enhanced by the FAAH inhibitor URB597 on coping styles in rats

(2013) Jozsef Haller et al.   PSYCHOPHARMACOLOGY

The Endocannabinoids Anandamide and Virodhamine Modulate the Activity of the Candidate Cannabinoid Receptor GPR55

(2012) Haleli Sharir et al.   Journal of Neuroimmune Pharmacology

A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase

(2012) Laura Bertolacci et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dorsal root ganglion – a potential new therapeutic target for neuropathic pain

(2012) Damir Sapunar et al.   Journal of Pain Research

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH)

(2011) Katerina Otrubova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

(2011) Gai Ling Li et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Approximating Protein Flexibility through Dynamic Pharmacophore Models: Application to Fatty Acid Amide Hydrolase (FAAH)

(2011) Anna L. Bowman et al.   Journal of Chemical Information and Modeling

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide Hydrolase

(2011) Mauro Mileni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

(2011) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)

(2011) X. Min et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Open Babel: An open chemical toolbox

(2011) Noel M O'Boyle et al.   Journal of Cheminformatics

Analgesic effect of raloxifene on back and knee pain in postmenopausal women with osteoporosis and/or osteoarthritis

(2010) Takuo Fujita et al.   JOURNAL OF BONE AND MINERAL METABOLISM

PaDEL-descriptor: An open source software to calculate molecular descriptors and fingerprints

(2010) Chun Wei Yap   JOURNAL OF COMPUTATIONAL CHEMISTRY

Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation

(2010) Mauro Mileni et al.   JOURNAL OF MOLECULAR BIOLOGY

Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis

(2010) Niklas Schuelert et al.   PAIN

Targeting Fatty Acid Amide Hydrolase (FAAH) to Treat Pain and Inflammation

(2009) Joel E. Schlosburg et al.   AAPS Journal

Structure-Property Relationships of a Class of Carbamate-Based Fatty Acid Amide Hydrolase (FAAH) Inhibitors: Chemical and Biological Stability

(2009) Federica Vacondio et al.   ChemMedChem

Mechanism of action of a new class of insulin secretagogues

(2009) W. J. Malaisse   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Inhibition of fatty acid amide hydrolase produces PPAR-α-mediated analgesia in a rat model of inflammatory pain

(2008) D R Sagar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis and Quantitative Structure−Activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates

(2008) Marco Mor et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Fatty Acid Amide Hydrolase (FAAH) Inhibitors

(2008) Mark Seierstad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Benzothiazole-Based Analogues as Novel, Potent, and Selective Fatty Acid Amide Hydrolase Inhibitors

(2008) Xueqing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of Raloxifen in treatment of fibromyalgia in menopausal women

(2007) Shahram Sadreddini et al.   European Journal of Internal Medicine