Chemotherapy-Mediated Neuronal Aberration

Anthracycline-induced cardiotoxicity — are we about to clear this hurdle?

(2023) Wolfram C.M. Dempke et al.   EUROPEAN JOURNAL OF CANCER

Resveratrol Improves Paclitaxel-Induced Cognitive Impairment in Mice by Activating SIRT1/PGC-1α Pathway to Regulate Neuronal State and Microglia Cell Polarization

(2023) Xin Liu et al.   Drug Design Development and Therapy

Independent Drug Action in Combination Therapy: Implications for Precision Oncology

(2022) Deborah Plana et al.   Cancer Discovery

Neuroprotective effect of Mulmina Mango against chemotherapy-induced cognitive decline in mouse model of mammary carcinoma

(2022) Jeena John et al.   Scientific Reports

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

(2022) Xiaowei Xu et al.   Frontiers in Pharmacology

Mechanisms of Chemotherapy-Induced Neurotoxicity

(2022) Halina Was et al.   Frontiers in Pharmacology

Paclitaxel induces cognitive impairment via necroptosis, decreased synaptic plasticity and M1 polarisation of microglia

(2022) Miao Tang et al.   PHARMACEUTICAL BIOLOGY

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

(2021) Damien Bertheloot et al.   Cellular & Molecular Immunology

Cognitive complications of cancer and cancer-related treatments – Novel paradigms

(2021) Naomi Lomeli et al.   NEUROSCIENCE LETTERS

Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights

(2021) Jiajia Du et al.   Frontiers in Oncology

Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?

(2021) Thijs A. van Schaik et al.   Frontiers in Oncology

Pathomechanisms of Paclitaxel-Induced Peripheral Neuropathy

(2021) Ines Klein et al.   Toxics

Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation

(2021) Matin Alavi et al.   Cancer Cell International

Animal models of chemotherapy-induced cognitive decline in preclinical drug development

(2021) Jeena John et al.   PSYCHOPHARMACOLOGY

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

(2020) Amit S. Choudhari et al.   Frontiers in Pharmacology

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

(2020) Lien D Nguyen et al.   EMBO Molecular Medicine

Potential Adverse Effects of Resveratrol: A Literature Review

(2020) Abdullah Shaito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Naringenin Regulates Doxorubicin-Induced Liver Dysfunction: Impact on Oxidative Stress and Inflammation

(2020) Adil Farooq Wali et al.   Plants-Basel

Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism

(2020) Pradip Kumar Jaiswara et al.   ENVIRONMENTAL TOXICOLOGY

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy

(2019) Qicai Xiao et al.   Frontiers in Pharmacology

Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu

(2019) Kaviyarasi Renu et al.   Reproductive Biology

Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of many cancer survivors

(2019) Xiaojia Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Chemotherapy accelerates age-related development of tauopathy and results in loss of synaptic integrity and cognitive impairment

(2019) Angie C.A. Chiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

(2019) Si-Tong Feng et al.   PHARMACOLOGICAL RESEARCH

Early Effects of Cyclophosphamide, Methotrexate, and 5-Fluorouracil on Neuronal Morphology and Hippocampal-Dependent Behavior in a Murine Model

(2019) Julie E Anderson et al.   TOXICOLOGICAL SCIENCES

Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions

(2019) Benjamin Ongnok et al.   EXPERIMENTAL NEUROLOGY

Proinflammatory Factors Mediate Paclitaxel-Induced Impairment of Learning and Memory

(2018) Zhao Li et al.   MEDIATORS OF INFLAMMATION

Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity

(2018) Dong-Dong Shi et al.   MOLECULAR NEUROBIOLOGY

Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: Involvement of cytokine modulation and neuroprotection

(2018) Dong-Dong Shi et al.   NEUROBIOLOGY OF DISEASE

PAN-811 prevents chemotherapy-induced cognitive impairment and preserves neurogenesis in the hippocampus of adult rats

(2018) Zhi-Gang Jiang et al.   PLoS One

Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)

(2018) Jeriel T.R. Keeney et al.   Oncotarget

Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk

(2018) Fumiko Sekiguchi et al.   NEUROPHARMACOLOGY

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment

(2018) Erin M. Gibson et al.   CELL

Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice

(2018) Gabriel S. Chiu et al.   Oncotarget

Preventive Effect of Curcumin Against Chemotherapy-Induced Side-Effects

(2018) Zhijun Liu et al.   Frontiers in Pharmacology

Verbal memory in breast cancer patients treated with chemotherapy with doxorubicin and cyclophosphamide

(2017) P. Andryszak et al.   EUROPEAN JOURNAL OF CANCER CARE

The Role of Resveratrol in Cancer Therapy

(2017) Jeong-Hyeon Ko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The IL-1β phenomena in neuroinflammatory diseases

(2017) Andrew S. Mendiola et al.   JOURNAL OF NEURAL TRANSMISSION

Changes in Brain Structural Networks and Cognitive Functions in Testicular Cancer Patients Receiving Cisplatin-Based Chemotherapy

(2017) Ali Amidi et al.   JNCI-Journal of the National Cancer Institute

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

(2017) Muhammad Imran et al.   Lipids in Health and Disease

Preclinical studies for the combination of paclitaxel and curcumin in cancer therapy

(2017) Yumeng Wei et al.   ONCOLOGY REPORTS

Dysregulation of cytokine mediated chemotherapy induced cognitive impairment

(2017) Xiaojia Ren et al.   PHARMACOLOGICAL RESEARCH

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

(2017) Grandhi V Ramalingayya et al.   Drug Design Development and Therapy

Changes in Brain Structural Networks and Cognitive Functions in Testicular Cancer Patients Receiving Cisplatin-Based Chemotherapy

(2017) Ali Amidi et al.   JNCI-Journal of the National Cancer Institute

Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function

(2016) Gabriel S. Chiu et al.   CANCER RESEARCH

Molecular mechanisms for tumour resistance to chemotherapy

(2016) Shu-Ting Pan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Markers of Glutamate Metabolism in Peripheral Blood Mononuclear Cells and Neurological Complications in Lung Cancer Patients

(2016) Slawomir Michalak et al.   DISEASE MARKERS

Edaravone alleviates cisplatin-induced neurobehavioral deficits via modulation of oxidative stress and inflammatory mediators in the rat hippocampus

(2016) Ashok Jangra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction

(2016) Hannah R. Wardill et al.   INTERNATIONAL JOURNAL OF CANCER

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Role of Natural Radiosensitizers and Cancer Cell Radioresistance: An Update

(2016) Arif Malik et al.   Analytical Cellular Pathology

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Long Chain Omega-3 Polyunsaturated Fatty Acid Supplementation Alleviates Doxorubicin-Induced Depressive-Like Behaviors and Neurotoxicity in Rats: Involvement of Oxidative Stress and Neuroinflammation

(2016) Yan-Qin Wu et al.   Nutrients

Levetiracetam mitigates doxorubicin-induced DNA and synaptic damage in neurons

(2016) Jose Felix Moruno Manchon et al.   Scientific Reports

Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice

(2016) Wenjun Zhou et al.   PLoS One

Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study†

(2015) Y. T. Cheung et al.   ANNALS OF ONCOLOGY

The double-edged sword: Neurotoxicity of chemotherapy

(2015) Rajiv S. Magge et al.   BLOOD REVIEWS

MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy

(2015) Yan Li et al.   BRAIN BEHAVIOR AND IMMUNITY

Naringin Abrogates Cisplatin-Induced Cognitive Deficits and Cholinergic Dysfunction Through the Down-Regulation of AChE Expression and iNOS Signaling Pathways in Hippocampus of Aged Rats

(2015) Yassine Chtourou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cognitive and Brain Structural Changes in a Lung Cancer Population

(2015) Marta Simó et al.   Journal of Thoracic Oncology

Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis

(2015) M F Brown et al.   Cell Death & Disease

A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy

(2015) J. A. Lawrence et al.   Journal of Cancer Survivorship

Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer

(2015) Nirmala Chandralega Kampan et al.   Biomed Research International

Low-doses of cisplatin injure hippocampal synapses: A mechanism for ‘chemo’ brain?

(2014) Adrienne L. Andres et al.   EXPERIMENTAL NEUROLOGY

The 2013 SFRBM discovery award: Selected discoveries from the butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment

(2014) D. Allan Butterfield   FREE RADICAL BIOLOGY AND MEDICINE

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Receptor Interactive Protein Kinase 3 Promotes Cisplatin-Triggered Necrosis in Apoptosis-Resistant Esophageal Squamous Cell Carcinoma Cells

(2014) Yang Xu et al.   PLoS One

Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production

(2014) Yalda Shokoohinia et al.   Biomed Research International

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species

(2014) Céline Vaure et al.   Frontiers in Immunology

Systemic chemotherapy decreases brain glucose metabolism

(2014) Laura L. Horky et al.   Annals of Clinical and Translational Neurology

Relationship between exercise behavior, cardiorespiratory fitness, and cognitive function in early breast cancer patients treated with doxorubicin-containing chemotherapy: a pilot study

(2013) Theresa Crowgey et al.   Applied Physiology Nutrition and Metabolism

Paclitaxel induces neurotoxicity through endoplasmic reticulum stress

(2013) Hitoshi Tanimukai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulation in myelination mediated by persistent neuroinflammation: Possible mechanisms in chemotherapy-related cognitive impairment

(2013) Teresita L. Briones et al.   BRAIN BEHAVIOR AND IMMUNITY

Curcumin and Diabetes: A Systematic Review

(2013) Dong-wei Zhang et al.   Evidence-based Complementary and Alternative Medicine

Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging

(2013) Ayesha Maqbool et al.   Molecular Neurodegeneration

Reactive Oxygen Species from Human Astrocytes Induced Functional Impairment and Oxidative Damage

(2013) Wen S. Sheng et al.   NEUROCHEMICAL RESEARCH

Cisplatin Inhibits Hippocampal Cell Proliferation and Alters the Expression of Apoptotic Genes

(2013) Senthilvelan Manohar et al.   NEUROTOXICITY RESEARCH

Cytokines as Mediators of Chemotherapy-Associated Cognitive Changes: Current Evidence, Limitations and Directions for Future Research

(2013) Yin Ting Cheung et al.   PLoS One

The effect of 5-fluorouracil on the long term survival and proliferation of cells in the rat hippocampus

(2012) Maha ELBeltagy et al.   BRAIN RESEARCH BULLETIN

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

(2012) R. B. Mythri et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial dysfunction mediated cisplatin induced toxicity: Modulatory role of curcumin

(2012) Mohammad Waseem et al.   FOOD AND CHEMICAL TOXICOLOGY

Neuropsychological Performance in Survivors of Breast Cancer More Than 20 Years After Adjuvant Chemotherapy

(2012) Vincent Koppelmans et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical trials of resveratrol

(2011) Ketan R. Patel et al.   Annals of the New York Academy of Sciences

Epicatechin attenuates doxorubicin-induced brain toxicity: Critical role of TNF-α, iNOS and NF-κB

(2011) Rasha H. Mohamed et al.   BRAIN RESEARCH BULLETIN

A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study

(2011) Joseph Chao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Role of Phytochemicals in the Treatment and Prevention of Dementia

(2011) Melanie-Jayne R. Howes et al.   DRUGS & AGING

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: Implications for the reactive oxygen species-mediated mechanisms of chemobrain

(2011) Christopher D. Aluise et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese Superoxide Dismutase: Guardian of the Powerhouse

(2011) Aaron K. Holley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model

(2011) Gordon Winocur et al.   NEUROPHARMACOLOGY

Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

(2011) Leanne Stevenson et al.   PLoS One

A Switching Mechanism in Doxorubicin Bioactivation Can Be Exploited to Control Doxorubicin Toxicity

(2011) Nnenna A. Finn et al.   PLoS Computational Biology

Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis

(2010) V. A. Brown et al.   CANCER RESEARCH

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia Mangostana

(2010) J. Tangpong et al.   NEUROSCIENCE

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

(2010) Koh Miura et al.   Cancers

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Peripheral Cytokines and Chemokines in Alzheimer’s Disease

(2009) Kang Soo Lee et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Persistent Neurocognitive Problems After Adjuvant Chemotherapy for Breast Cancer

(2008) Baudewijntje P.C. Kreukels et al.   Clinical Breast Cancer

5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus

(2008) Sarah Mustafa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Update on Uses and Properties of Citrus Flavonoids: New Findings in Anticancer, Cardiovascular, and Anti-inflammatory Activity

(2008) O. Benavente-García et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY