Manganese Superoxide Dismutase: Guardian of the Powerhouse

Mitochondrial Dysfunction in Parkinson's Disease

(2017) Jianhui Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress

(2016) Ozkan Ozden et al.   Aging-US

Manganese Superoxide Dismutase (Sod2) and Redox-Control of Signaling Events That Drive Metastasis

(2012) Nadine Hempel et al.   Anti-Cancer Agents in Medicinal Chemistry

MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging

(2011) Michael S. Lustgarten et al.   AGING CELL

Mitochondrial Dynamics and Parkinson's Disease: Focus on Parkin

(2011) Kah-Leong Lim et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

MnSOD Overexpression Prevents Liver Mitochondrial DNA Depletion after an Alcohol Binge but Worsens This Effect after Prolonged Alcohol Consumption in Mice

(2011) Abdellah Mansouri et al.   DIGESTIVE DISEASES

SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival

(2011) Subhas Mukherjee et al.   FLY

Generation and characterization of a novel kidney-specific manganese superoxide dismutase knockout mouse

(2011) Nirmala Parajuli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13)

(2011) Kazuya Sato et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

(2011) Ariel C. Bulua et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

SOD2 Deficient Erythroid Cells Up-Regulate Transferrin Receptor and Down-Regulate Mitochondrial Biogenesis and Metabolism

(2011) Florent M. Martin et al.   PLoS One

MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure

(2010) Jordan D. Miller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation

(2010) Yulia Y. Tyurina et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Human Iron−Sulfur Cluster Assembly, Cellular Iron Homeostasis, and Disease

(2010) Hong Ye et al.   BIOCHEMISTRY

Oxidative phosphorylation in cancer cells

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease

(2010) F. Meissner et al.   BLOOD

Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer

(2010) Song Yao et al.   BREAST CANCER RESEARCH AND TREATMENT

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide

(2010) Mariano Redondo-Horcajo et al.   CARDIOVASCULAR RESEARCH

Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson's disease

(2010) Vinchi Wang et al.   CLINICAL BIOCHEMISTRY

Mutation in the abcb7 gene causes abnormal iron and fatty acid metabolism in developing medaka fish

(2010) Akimitsu Miyake et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Manganese Superoxide Dismutase Protects Pol γ Against UVinduced Inactivation: Implication for DNA Repair

(2010) Vasudevan Bakthavatchalu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

(2010) Giuseppe Paradies et al.   FREE RADICAL BIOLOGY AND MEDICINE

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge

(2010) Adam J. Case et al.   FREE RADICAL BIOLOGY AND MEDICINE

Degradation of phospholipids by oxidative stress—Exceptional significance of cardiolipin

(2010) Ingrid Wiswedel et al.   FREE RADICAL RESEARCH

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

(2010) Shankar J. Chinta et al.   FREE RADICAL RESEARCH

Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase

(2010) Sally A. Madsen-Bouterse et al.   FREE RADICAL RESEARCH

Advances in methods for the determination of biologically relevant lipid peroxidation products

(2010) Corinne M. Spickett et al.   FREE RADICAL RESEARCH

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion

(2010) Sun-Mi Lee et al.   IMMUNOLOGY LETTERS

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Evidence for Mitochondrial Respiratory Deficiency in Rat Rhabdomyosarcoma Cells

(2010) Vanessa E. Jahnke et al.   PLoS One

Direct assignment of EPR spectra to structurally defined iron-sulfur clusters in complex I by double electron-electron resonance

(2010) M. M. Roessler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

(2010) D. R. Richardson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese Superoxide Dismutase (MnSOD) Polymorphism, Alcohol, Cigarette Smoking and Risk of Oesophageal Cancer

(2009) L. Sun et al.   ALCOHOL AND ALCOHOLISM

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity

(2009) Michael S. Lustgarten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Supramolecular organization of ATP synthase and respiratory chain in mitochondrial membranes

(2009) Ilka Wittig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function

(2009) Steven M. Claypool   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The enigmatic role of tafazzin in cardiolipin metabolism

(2009) Riekelt H. Houtkooper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Post-translational modifications of superoxide dismutase

(2009) Fumiyuki Yamakura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Trace elements in hemodialysis patients: a systematic review and meta-analysis

(2009) Marcello Tonelli et al.   BMC Medicine

Association between manganese superoxide dismutase polymorphism and risk of lung cancer

(2009) Jasmina Zejnilovic et al.   CANCER GENETICS AND CYTOGENETICS

Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice

(2009) Tomasz Loch et al.   CARDIOVASCULAR RESEARCH

Association of a new intronic polymorphism of theSOD2gene (G1677T) with cancer

(2009) Daniel Hernandez-Saavedra et al.   CELL BIOCHEMISTRY AND FUNCTION

Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease

(2009) Giuseppe Paradies et al.   CELL CALCIUM

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

(2009) Jianxin Lu et al.   CELL RESEARCH

A Mitochondrial Target Sequence Polymorphism in Manganese Superoxide Dismutase Predicts Inferior Survival in Breast Cancer Patients Treated with Cyclophosphamide

(2009) S. A. Glynn et al.   CLINICAL CANCER RESEARCH

Ammonia toxicity and its prevention in inherited defects of the urea cycle

(2009) V. Walker   DIABETES OBESITY & METABOLISM

Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents

(2009) Joachim Kienhöfer et al.   FASEB JOURNAL

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria

(2009) Maurizio Sorice et al.   FEBS LETTERS

Regulation of superoxide dismutase genes: Implications in disease

(2009) Lu Miao et al.   FREE RADICAL BIOLOGY AND MEDICINE

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Association of the manganese superoxide dismutase polymorphism with vasospastic angina pectoris

(2009) Hajime Fujimoto et al.   Journal of Cardiology

Enhanced modification of cardiolipin during ischemia in the aged heart

(2009) Edward J. Lesnefsky et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hepatic Mitochondrial DNA Depletion after an Alcohol Binge in Mice: Probable Role of Peroxynitrite and Modulation by Manganese Superoxide Dismutase

(2009) I. Larosche et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Redox modulation of global phosphatase activity and protein phosphorylation in intact skeletal muscle

(2009) Valerie P. Wright et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

(2009) Nicolas Abello et al.   JOURNAL OF PROTEOME RESEARCH

Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells

(2009) Aaron K. Holley et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

(2009) Y. C. Jang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

How mitochondria record the effects of UV exposure and oxidative stress using human skin as a model tissue

(2009) M. A. Birch-Machin et al.   MUTAGENESIS

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

The Warburg Effect Suppresses Oxidative Stress Induced Apoptosis in a Yeast Model for Cancer

(2009) Christoph Ruckenstuhl et al.   PLoS One

Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures

(2009) David Cantu et al.   PLoS One

Targeting Mitochondria

(2008) Adam T. Hoye et al.   ACCOUNTS OF CHEMICAL RESEARCH

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

(2008) Viviana I. Pérez et al.   AGING CELL

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Evolution of Catalases from Bacteria to Humans

(2008) Marcel Zamocky et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxynitrite-mediated lipid oxidation and nitration: Mechanisms and consequences

(2008) Homero Rubbo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The role of iron in mitochondrial function

(2008) Sonia Levi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oxidative and nitrosative stress in Parkinson's disease

(2008) Anthony H.K. Tsang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Copper, Chromium, Manganese, Iron, Nickel, and Zinc Levels in Biological Samples of Diabetes Mellitus Patients

(2008) Tasneem Gul Kazi et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Target Sequence Polymorphism of Human Manganese Superoxide Dismutase Gene and Its Association with Cancer Risk: A Review

(2008) A. Bag et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Reactive oxygen species and HIF-1 signalling in cancer

(2008) Alex Galanis et al.   CANCER LETTERS

Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection

(2008) Sergiy M. Nadtochiy et al.   CARDIOVASCULAR RESEARCH

Manganese superoxide dismutase and aldehyde dehydrogenase deficiency increase mitochondrial oxidative stress and aggravate age-dependent vascular dysfunction

(2008) Philip Wenzel et al.   CARDIOVASCULAR RESEARCH

Manganese superoxide dismutase (MnSOD) genetic polymorphism is associated with risk of early-onset prostate cancer

(2008) Zorica Arsova-Sarafinovska et al.   CELL BIOCHEMISTRY AND FUNCTION

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE

Mitochondrial DNA oxidation and manganese superoxide dismutase activity in peripheral blood mononuclear cells from type 2 diabetic patients

(2008) M. García-Ramírez et al.   DIABETES & METABOLISM

The manganese superoxide dismutase Ala16Val dimorphism modulates iron accumulation in human hepatoma cells

(2008) P NAHON et al.   FREE RADICAL BIOLOGY AND MEDICINE

Convergence of nitric oxide and lipid signaling: Anti-inflammatory nitro-fatty acids

(2008) Paul R.S. Baker et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress caused by blocking of mitochondrial Complex I H+ pumping as a link in aging/disease vicious cycle

(2008) Andrea Dlasková et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cardiolipin provides an essential activating platform for caspase-8 on mitochondria

(2008) Francois Gonzalvez et al.   JOURNAL OF CELL BIOLOGY

Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

(2008) Michael A. Kiebish et al.   JOURNAL OF LIPID RESEARCH

Manganese superoxide dismutase gene polymorphism, MnSOD plasma levels and risk of epithelial ovarian cancer

(2008) Altay Burak Dalan et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

A neuronal model of Alzheimer's disease: An insight into the mechanisms of oxidative stress–mediated mitochondrial injury

(2008) P. Sompol et al.   NEUROSCIENCE

Decrease in Manganese Superoxide Dismutase Leads to Reduced Root Growth and Affects Tricarboxylic Acid Cycle Flux and Mitochondrial Redox Homeostasis

(2008) M. J. Morgan et al.   PLANT PHYSIOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Inflammasomes and rheumatic diseases: evolving concepts

(2007) P I Sidiropoulos et al.   ANNALS OF THE RHEUMATIC DISEASES