Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1

Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

(2023) Yuji Kamioka et al.   Cell Reports

Expression of the phagocytic receptors αMβ2 and αXβ2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells

(2022) Alvaro Torres-Gomez et al.   Frontiers in Immunology

Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1

(2021) Naoyuki Kondo et al.   Science Signaling

Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling

(2020) Lai Wen et al.   BLOOD

Phosphoinositides regulate force-independent interactions between talin, vinculin, and actin

(2020) Charlotte F Kelley et al.   eLife

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

(2019) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells

(2019) Maureen Keller et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+T cells

(2018) Federica Moalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells

(2018) Miroslav Hons et al.   NATURE IMMUNOLOGY

Fam65b Phosphorylation Relieves Tonic RhoA Inhibition During T Cell Migration

(2018) Laura Megrelis et al.   Frontiers in Immunology

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs

(2018) Bing Wu et al.   IMMUNITY

Antigen Availability and DOCK2-Driven Motility Govern CD4+T Cell Interactions with Dendritic Cells In Vivo

(2017) Markus Ackerknecht et al.   JOURNAL OF IMMUNOLOGY

NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization

(2017) Naoyuki Kondo et al.   MOLECULAR AND CELLULAR BIOLOGY

Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration

(2017) Miriam L. Estin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

(2017) María-José Sandí et al.   Science Signaling

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity

(2017) María-José Sandí et al.   Science Signaling

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

(2016) Katarzyna Plak et al.   BMC CELL BIOLOGY

Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition

(2016) Yoshihiro Ueda et al.   JOURNAL OF IMMUNOLOGY

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

Homer3 regulates the establishment of neutrophil polarity

(2015) Julie Wu et al.   MOLECULAR BIOLOGY OF THE CELL

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

(2015) Fengyuan Tang et al.   Science Signaling

Signaling Networks that Regulate Cell Migration

(2015) Peter Devreotes et al.   Cold Spring Harbor Perspectives in Biology

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

(2015) Fengyuan Tang et al.   Science Signaling

Detection of Rare Antigen-Presenting Cells through T Cell-Intrinsic Meandering Motility, Mediated by Myo1g

(2014) Audrey Gérard et al.   CELL

Jak3 Enables Chemokine-Dependent Actin Cytoskeleton Reorganization by Regulating Cofilin and Rac/Rhoa GTPases Activation

(2014) Xochitl Ambriz-Peña et al.   PLoS One

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

The Cell Polarity Protein mInsc Regulates Neutrophil Chemotaxis via a Noncanonical G Protein Signaling Pathway

(2013) Sachiko Kamakura et al.   DEVELOPMENTAL CELL

JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation

(2013) Alessio Montresor et al.   JOURNAL OF CELL BIOLOGY

Vinculin Arrests Motile B Cells by Stabilizing Integrin Clustering at the Immune Synapse

(2013) J. Saez de Guinoa et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1

(2013) T. Katakai et al.   JOURNAL OF IMMUNOLOGY

Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

(2013) Hongyan Li et al.   Nature Communications

Membrane Tension Maintains Cell Polarity by Confining Signals to the Leading Edge during Neutrophil Migration

(2012) Andrew R. Houk et al.   CELL

A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion

(2012) Xianqiang Song et al.   CELL RESEARCH

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes

(2012) Fan Mou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis

(2012) M. Tsujioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus

(2012) Yoshihiro Ueda et al.   Nature Communications

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA–regulated adhesions

(2010) Jordan Jacobelli et al.   NATURE IMMUNOLOGY

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes

(2009) Koko Katagiri et al.   EMBO JOURNAL

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

(2009) S. Kupzig et al.   MOLECULAR AND CELLULAR BIOLOGY

The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis

(2009) F. Wang   Cold Spring Harbor Perspectives in Biology

ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA

(2008) Shuh-hei Fujishiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1

(2008) Jeffrey C. Nolz et al.   JOURNAL OF CELL BIOLOGY