Kindlin-3 disrupts an intersubunit association in the integrin LFA1 to trigger positive feedback activation by Rap1 and talin1

Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling

(2020) Lai Wen et al.   BLOOD

Tensile force transmitted through LFA‐1 bonds mechanoregulate neutrophil inflammatory response

(2020) Vasilios A. Morikis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice

(2018) Thomas Bromberger et al.   BLOOD

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Energy landscape differences among integrins establish the framework for understanding activation

(2017) Jing Li et al.   JOURNAL OF CELL BIOLOGY

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization

(2017) Naoyuki Kondo et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

(2017) Liang Zhu et al.   Nature Communications

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

(2016) Katarzyna Plak et al.   BMC CELL BIOLOGY

The kindlin family: functions, signaling properties and implications for human disease

(2016) Emanuel Rognoni et al.   JOURNAL OF CELL SCIENCE

Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node

(2016) Tomoya Katakai et al.   Frontiers in Immunology

Talin and kindlin: the one-two punch in integrin activation

(2014) Feng Ye et al.   Frontiers of Medicine

The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis

(2013) S. J. Cohen et al.   BLOOD

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Dendritic Cells Regulate High-Speed Interstitial T Cell Migration in the Lymph Node via LFA-1/ICAM-1

(2013) T. Katakai et al.   JOURNAL OF IMMUNOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

(2013) F. A. Moretti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes

(2011) R. Evans et al.   BLOOD

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Contact-Dependent T Cell Activation and T Cell Stopping Require Talin1

(2011) S. A. Wernimont et al.   JOURNAL OF IMMUNOLOGY

Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions

(2009) E. Manevich-Mendelson et al.   BLOOD

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

β1Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1

(2009) J. Angelo Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Structure of an integrin  IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

(2009) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges

(2008) Sophie Rodius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions (Review)

(2008) Kate L. Wegener et al.   MOLECULAR MEMBRANE BIOLOGY