Co-delivery of gemcitabine and paclitaxel plus NanoCpG empowers chemoimmunotherapy of postoperative “cold” triple-negative breast cancer

Tumor-permeable smart liposomes by modulating the tumor microenvironment to improve the chemotherapy

(2022) Andy Samuel Widjaya et al.   JOURNAL OF CONTROLLED RELEASE

Multifunctional Lipid Bilayer Nanocarriers for Cancer Immunotherapy in Heterogeneous Tumor Microenvironments, Combining Immunogenic Cell Death Stimuli with Immune Modulatory Drugs

(2022) André E. Nel et al.   ACS Nano

CD44-targeting hydrophobic phosphorylated gemcitabine prodrug nanotherapeutics augment lung cancer therapy

(2022) Beibei Guo et al.   Acta Biomaterialia

Immunotherapy of Malignant Glioma by Noninvasive Administration of TLR9 Agonist CpG Nano‐Immunoadjuvant

(2022) Jingjing Wei et al.   Advanced Science

Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple‐Negative Breast Cancer

(2022) Zitong Zhao et al.   ADVANCED MATERIALS

Pembrolizumab versus investigator-choice chemotherapy for metastatic triple-negative breast cancer (KEYNOTE-119): a randomised, open-label, phase 3 trial

(2021) Eric P Winer et al.   LANCET ONCOLOGY

Tumor hypoxia-activated combinatorial nanomedicine triggers systemic antitumor immunity to effectively eradicate advanced breast cancer

(2021) Jing Liu et al.   BIOMATERIALS

Improving anti-PD-L1 therapy in triple negative breast cancer by polymer-enhanced immunogenic cell death and CXCR4 blockade

(2021) Minglu Zhou et al.   JOURNAL OF CONTROLLED RELEASE

Systemic administration of polymersomal oncolytic peptide LTX-315 combining with CpG adjuvant and anti-PD-1 antibody boosts immunotherapy of melanoma

(2021) Yifeng Xia et al.   JOURNAL OF CONTROLLED RELEASE

Biomimetic Liposome with Surface‐Bound Elastase for Enhanced Tumor Penetration and Chemo‐Immumotherapy

(2021) Yong‐Jiang Li et al.   Advanced Healthcare Materials

ROS-responsive amphiphilic block copolymer-drug conjugate: Design, synthesis and potential as an efficient drug delivery system via a positive feedback strategy

(2021) Bing Wang et al.   CHEMICAL ENGINEERING JOURNAL

Micellar paclitaxel boosts ICD and chemo-immunotherapy of metastatic triple negative breast cancer

(2021) Xinyun Qiu et al.   JOURNAL OF CONTROLLED RELEASE

Treatment landscape of triple-negative breast cancer — expanded options, evolving needs

(2021) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Targeting Innate Immunity in Breast Cancer Therapy: A Narrative Review

(2021) Yanqi Ye et al.   Frontiers in Immunology

Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel

(2020) Linlin Li et al.   ACS Applied Materials & Interfaces

Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy

(2020) Songlei Zhou et al.   BIOMATERIALS

Co‐Delivery of Paclitaxel and Interleukin‐12 Regulating Tumor Microenvironment for Cancer Immunochemotherapy

(2020) Qian Hu et al.   Advanced Healthcare Materials

Pathology of triple negative breast cancer

(2020) Filippo Borri et al.   SEMINARS IN CANCER BIOLOGY

Turning up the heat on non-immunoreactive tumours: opportunities for clinical development

(2020) María Ochoa de Olza et al.   LANCET ONCOLOGY

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Magnetic-responsive and targeted cancer nanotheranostics by PA/MR bimodal imaging-guided photothermally triggered immunotherapy

(2019) Yuan Guo et al.   BIOMATERIALS

Mitochondria-targeting nanomedicine self-assembled from GSH-responsive paclitaxel-ss-berberine conjugate for synergetic cancer treatment with enhanced cytotoxicity

(2019) Yu Cheng et al.   JOURNAL OF CONTROLLED RELEASE

Self-Delivery Micellar Nanoparticles Prevent Premetastatic Niche Formation by Interfering with the Early Recruitment and Vascular Destruction of Granulocytic Myeloid-Derived Suppressor Cells

(2019) Yang Long et al.   NANO LETTERS

Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy

(2018) Hathaichanok Phuengkham et al.   ADVANCED MATERIALS

Rational Design of Redox-Responsive and P-gp-Inhibitory Lipid Nanoparticles with High Entrapment of Paclitaxel for Tumor Therapy

(2018) Shao-Qing Chen et al.   Advanced Healthcare Materials

Local Blockade of Interleukin 10 and C-X-C Motif Chemokine Ligand 12 with Nano-Delivery Promotes Antitumor Response in Murine Cancers

(2018) Limei Shen et al.   ACS Nano

Paclitaxel reduces tumor growth by reprogramming tumor-associated macrophages to an M1- profile in a TLR4-dependent manner

(2018) Carlos W Wanderley et al.   CANCER RESEARCH

Degradation-Regulatable Architectured Implantable Macroporous Scaffold for the Spatiotemporal Modulation of Immunosuppressive Microenvironment and Enhanced Combination Cancer Immunotherapy

(2018) Long Ren et al.   ADVANCED FUNCTIONAL MATERIALS

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

(2018) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

ATN-161 Peptide Functionalized Reversibly Cross-Linked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice

(2017) Ning Zhang et al.   MOLECULAR PHARMACEUTICS

Natural Killer T-cell Immunotherapy in Combination with Chemotherapy-Induced Immunogenic Cell Death Targets Metastatic Breast Cancer

(2017) Simon Gebremeskel et al.   Cancer Immunology Research

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Gemcitabine-treated pancreatic cancer cell medium induces the specific CTL antitumor activity by stimulating the maturation of dendritic cells

(2014) Qingshan Pei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antitumor Activity Mediated by CpG

(2011) Yanyan Lou et al.   JOURNAL OF IMMUNOTHERAPY

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell-Dependent Antitumor Immunity

(2010) J. Vincent et al.   CANCER RESEARCH