Article
Nanoscience & Nanotechnology
Jiawen Zhao, Liang Zhang, Yingjie Qi, Kui Liao, Zhigang Wang, Ming Wen, Di Zhou
Summary: The study successfully developed multifunctional nanoparticles with targeted therapeutic and diagnostic imaging capabilities for combination therapy of ovarian cancer. These nanoparticles showed excellent dispersity, stability, and optical properties, with a combination of photothermal conversion and chemotherapy achieving highly efficient therapy both in vitro and in vivo. The nanoparticles have the potential for therapeutic guidance and monitoring, with outstanding imaging capabilities for both photoacoustic and X-ray computed tomography imaging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Tian-Xing Zhang, Xiaoxue Hou, Yong Kong, Fan Yang, Yu-Xin Yue, Muhammad Raza Shah, Hua-Bin Li, Fan Huang, Jianfeng Liu, Dong-Sheng Guo
Summary: This study presents a novel supramolecular photothermal agent (PTA) prepared using a stimuli-responsive macrocyclic host, which overcomes the challenges of hydrophobicity, photodegradation, and low signal-to-noise ratio faced by organic small-molecule PTAs. The supramolecular PTA demonstrates enhanced solubility, photostability, and photothermal conversion, and exhibits promising imaging-guided photothermal therapy efficacy both in vitro and in vivo.
Article
Engineering, Biomedical
Yanan Gao, Qingyu Zhao, Min Xiao, Xuefei Huang, Xuanjun Wu
Summary: The study investigates synergistic therapy combining immunotherapy with photothermal effect for targeting tumors. Administration of a multifunctional vaccine enhances antitumor CTL immunotherapy.
Article
Engineering, Biomedical
Sijie Song, Qi Wang, Jiangao Xie, Junduan Dai, Dilan Ouyang, Guoming Huang, Yuheng Guo, Chen Chen, Mengnan Wu, Tingjing Huang, Jingwen Ruan, Xiaofeng Cheng, Xucong Lin, Yu He, Elena A. A. Rozhkova, Zhaowei Chen, Huanghao Yang
Summary: This study developed a dual-stimulation activated turn-on T-1 imaging-based nanoparticulate system for precise apoptotic cancer therapy. The system utilizes a DNAzyme molecular device to connect a superparamagnetic quencher and a paramagnetic enhancer, which are released upon activation by the FTO enzyme. The restored T-1 signal from released Gd-DOTA complexes guides the location and time of laser irradiation, and the combination with HSP70 antisense oligonucleotides promotes tumor cell apoptosis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Ying Hao, Tailuo Liu, Hao Zhou, Jinrong Peng, Ka Li, Yuwen Chen
Summary: This study successfully synthesized MOF nanoparticles with a synergistic therapeutic effect combining photothermal and immunotherapy, enabling selective blocking of the PD-1/PD-L1 pathway within the tumor microenvironment. The nanoparticles demonstrated GSH-triggered release of PD-1/PD-L1 blockers and potent photothermal effects capable of efficiently killing tumor cells, as well as promoting the maturation of DC cells and activating immune responses under NIR irradiation. This novel method offers new possibilities for the synergistic treatment of tumors involving photothermal combined with immunotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Zachary R. Stephen, Miqin Zhang
Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Pharmacology & Pharmacy
Weirong Kang, Yuwei Liu, Weiping Wang
Summary: Immunotherapy has revolutionized cancer treatments by activating the immune system to effectively inhibit cancer progression. Recent advances in cancer immunotherapy, such as checkpoint blockades and adoptive cellular therapy, have shown remarkable clinical outcomes. However, low response rates and side effects limit the widespread use of immunotherapy. Nanomedicine, specifically light-responsive nanoplatforms, show promise in enhancing immunotherapy by precise drug delivery and modulation of the tumor microenvironment.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Nanoscience & Nanotechnology
Qingdong Li, Wenjuan Gao, Caiyun Zhang, Peng Wang, Xin Wang, Miao Yan, Wenguo Jiang, Zhengyan Wu, Pengfei Wei, Geng Tian, Guilong Zhang
Summary: The combination of magnetic nanoliposomes with UACs can enhance the efficacy of cancer treatment by ablating tumors via photothermal therapy, releasing chemotherapy drugs, promoting chemotherapy, increasing reactive oxygen species through catalyzing Fenton reactions, and inducing cancer ferroptosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Tong Huang, Xinzhi Xu, Chen Cheng, Jianxin Wang, Liping Yang
Summary: In this study, multifunctional nanoparticles (FTCPNPs) were synthesized to achieve the synergistic antitumor effects of photothermal therapy and photodynamic therapy. These nanoparticles can diagnose and treat uveal melanoma, offering a new approach to preserving patients' vision.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biophysics
Guize Li, Luohuizi Li, Zhiqiang Wang, Siqing Zhong, Mingkang Li, Hongwei Wang, Lin Yuan
Summary: The serious mismatch between bacterial infections and antibiotic production calls for the emergence of new antimicrobial materials. In this study, dopamine methacrylamide and N-isopropylacrylamide were polymerized to form a block copolymer, which was then encapsulated with polydopamine-coated magnetic nanoparticle clusters to create an antibacterial nanocomposite. The nanocomposite exhibited triple responses to light, heat, and magnetism, allowing it to effectively kill bacteria and capture/release bacteria. The results showed that the antibacterial effect of the nanocomposite was significantly higher than that of the magnetic nanoparticle clusters, and it also possessed excellent antibiofilm properties.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Guohai Liang, Jiamei Han, Da Xing
Summary: The Fe-ZDS complex developed in this study is a dual-functional agent with excellent biocompatibility and efficient renal clearance. It is capable of imaging-guided, precise photothermal therapy of tumors and exhibits higher optical absorption intensity in weakly acidic environments.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Shankun Yao, Yuncong Chen, Hongxia Xu, Fen Qi, Yuming Zhang, Tao Yang, Yanping Wu, Hongbao Fang, Weijiang He, Zijian Guo
Summary: Multimodal imaging-guided phototherapy using a hypoxia-activated near infrared probe has been developed for tumor elimination. The probe can release a fluorescence group under hypoxia, leading to enhanced NIR fluorescence signal. Additionally, the released group can generate singlet oxygen and exhibit photothermal effects. In vivo studies demonstrated selective enhancement of fluorescence and photoacoustic signals in the tumor region. Furthermore, the synergistic effect of photodynamic therapy and photothermal therapy significantly suppressed tumor growth.
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Article
Chemistry, Multidisciplinary
Yuwan Zhu, Mo Deng, Nannan Xu, Yingjun Xie, Xuewen Zhang
Summary: Using MONs@PDA-ICG nanotheranostic agent can produce ROS to kill cancer cells, as well as exhibit good photothermal performance for photothermal therapy (PTT). The O-2 generated by MONs decomposition can alleviate tumor hypoxia and further enhance the treatment effects of photodynamic therapy (PDT). The released Mn2+ ions make MONs@PDA-ICG serve as tumor microenvironments responsive to MRI contrast for highly sensitive and specific liver cancer diagnosis.
FRONTIERS IN CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Aishwarya Shetty, Heinrich Lang, Sudeshna Chandra
Summary: The intriguing properties of metal sulfide nanoparticles (=MxSy-NPs), particularly transition metal dichalcogenides, are discussed for their use in diverse biological applications. Recent advances in MxSy-NPs-based imaging (MRI, CT, optical and photoacoustic) and phototherapy (photothermal and photodynamic) are presented. The recent progress in the use of immuno-phototherapy combinatorial approaches in vitro and in vivo is also reported.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.