Article
Chemistry, Multidisciplinary
Huijuan Zhang, Yaping Wang, Ling Zhu, Zijun Qi, Kexuan Cao, Junbiao Chang, Lin Hou
Summary: Immune evasion is a challenge in PDAC therapy. Inhibiting autophagy improves antigen presentation and enhances immunogenic cell death (ICD) to stimulate anti-tumor immune response. However, the abundance of hyaluronic acid (HA)-dominated extracellular matrix hinders the penetration of autophagy inhibitors and ICD inducers. In this study, an intelligent system using hydroxychloroquine (HCQ) and doxorubicin (DOX) co-loaded into bacteria was developed for PDAC chemo-immunotherapy. The results showed that the system effectively targeted the tumor tissue, overcame the matrix barrier, and released HCQ and DOX in the tumor microenvironment to induce ICD and inhibit autophagy, thus improving the immunosuppressive TME and providing a new strategy for PDAC therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Jinxiang Liu, Jiaying Zhang, Yang Gao, Yuxuan Jiang, Zhenxin Guan, Yiying Xie, Jinghui Hu, Jing Chen
Summary: This review summarizes the barriers that limit the penetration of nanomedicines into tumors and proposes strategies to improve tumor permeation. Repairing abnormal tumor blood vessels and tumor stroma, as well as adjusting the physicochemical properties of nanoparticles, are considered promising approaches. The effects of nanoparticle properties, such as size, shape, and surface charge, on tumor penetration are also discussed. This review aims to provide research ideas and a scientific basis for enhancing intratumoral permeability and improving anti-tumor effects of nanomedicines.
Article
Chemistry, Physical
Yonghua Gong, Jinyang Zhang, Yan Lu, Dong Wan, Jie Pan, Guilei Ma
Summary: To address the challenges of poor drug permeation and immune-cold tumor microenvironment in solid tumors, light-activated nanoparticles were developed for co-delivery of chemotherapy drug, photosensitizer, and angiotensin II receptor blockers. These nanoparticles achieved deep drug penetration and synergistic photo-chemo-immunotherapy. In mouse models, the treatment effectively inhibited tumor growth, down-regulated a-smooth muscle actin expression, induced dendritic cells maturation, and promoted intratumoral infiltration of cytotoxic T lymphocytes. Combination therapy with the nanoparticles and anti-PD-1 monoclonal antibody showed potential for preventing tumor recurrence and metastasis by eliciting memory T cell response.
Article
Chemistry, Multidisciplinary
Qian Liu, Li Wang, Yitan Su, Wang Dong, Huiru Wang, Yang Liu, Hang Liu, Lianxin Liu, Yucai Wang
Summary: Protein drugs are potential candidates for treating complex diseases like cancer. Metal-organic-framework (MOF) is considered a promising carrier for encapsulating protein drugs, but its limited loading efficiency and potential toxicity hinder its clinical application. In this study, a tumor targeted collagenase-encapsulating MOF (PMOCol) is developed for refining deep tissue pancreatic cancer photoimmunotherapy. PMOCol demonstrates high encapsulation efficiency (80.3 wt%) and can effectively regulate extracellular matrix, enhancing immunocyte infiltration for cancer immunotherapy. By integrating a hyperthermia agent, PMOCol induces acute immunogenicity and systemic immune memory to prevent tumor development and recurrence.
Article
Immunology
Qing Zhao, Xuexin He, Xiyi Qin, Yu Liu, Han Jiang, Jing Wang, Shuang Wu, Rui Zhou, Congcong Yu, Suling Liu, Hong Zhang, Mei Tian
Summary: This study explores a novel combination therapy for TNBC using Losartan and Dox-L in combination with alpha-PD1, demonstrating that it can optimize the efficacy by reducing the stroma and enhancing immune stimulation, which improves the immunosuppressive microenvironment and enhances anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Meng Li, Yijing Zhang, Qin Zhang, Jingchao Li
Summary: Nanomedicines have shown promise in cancer therapy due to their increased safety and efficiency compared to small-molecule drugs. However, the dense extracellular matrix (ECM) in tumors often hinders the accumulation and diffusion of nanoparticles, reducing their anticancer efficacy. To overcome this, strategies such as degrading ECM components and inhibiting ECM formation have been employed to enhance the therapeutic effects of nanomedicines. By degrading ECM components or inhibiting ECM formation, the accumulation and diffusion of nanoparticles in tumors can be improved, leading to enhanced chemotherapy and phototherapy. Additionally, ECM degradation can enhance the infiltration of immune cells into tumor tissues, resulting in a stronger immune response against tumors.
MATERIALS TODAY BIO
(2022)
Review
Engineering, Biomedical
Xiaoxuan Xu, Yao Wu, Xindi Qian, Yuqi Wang, Jiaoying Wang, Jie Li, Yaping Li, Zhiwen Zhang
Summary: By regulating the physiochemical properties of nanomedicines and remodeling the components and structure of the ECM, intratumor ECM barriers can be effectively overcome, leading to improved drug delivery and anticancer efficacy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Medicine, Research & Experimental
Qian Zhang, Zi-Yi An, Wen Jiang, Wei-Lin Jin, Xin-Yang He
Summary: “Collagen, a major component of the extracellular matrix (ECM), plays a crucial role in tumor progression within the tumor microenvironment (TME). Recent studies have shown that collagen deposition in the TME affects tumor progression and interacts with tumor cells in complex ways. These findings highlight the potential of collagen as a target for cancer therapy.”
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Review
Immunology
Liangliang Meng, Yingtian Wei, Yueyong Xiao
Summary: Chemical ablation involves injecting chemical agents directly into solid tumors to kill cells and is currently used for palliative treatment. The effectiveness of different drugs has been clinically tested, but their diffusion and concentration limit their efficacy. Immunotherapy shows potential, but low patient response rates and immune-related adverse effects restrict its clinical applications. Intratumoral immunotherapy addresses these issues, but its efficacy alone is uncertain. This study focuses on the research of immunosuppressive tumor microenvironment with chemoablation and intratumoral immunotherapy, aiming to propose a new concept of intratumoral chemo-immunoablation that enhances the systemic anti-tumor immune response while reducing adverse drug effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lin Ding, Minli Liang, Yuanyuan Li, Mei Zeng, Meiting Liu, Wei Ma, Fuming Chen, Chenchen Li, Rui L. Reis, Fu-Rong Li, Yanli Wang
Summary: This article reports a zinc-organometallic framework vaccine (ZPM@OVA-CpG) prepared by self-assembly, which achieves site-directed release of zinc ions in dendritic cell (DC) lysosomes and tumor microenvironment under acidic conditions, significantly enhancing the cGAS-STING signal and promoting the activation of CD8(+) T cells. Moreover, the vaccine reaches the tumor site, releases zinc ions, and degrades collagen components of tumor ECM, effectively alleviating immune suppression and enhancing the infiltration and killing of CD8(+) T cells.
Article
Chemistry, Multidisciplinary
Jinbo Zhang, Lingpu Zhang, Jianmei Guo, Bingzheng Yu, Yingjie Yu, Chaoyong Liu
Summary: Chemo-photodynamic combination therapy is a promising cancer treatment strategy, but its effectiveness is limited by low selectivity and penetration of therapeutic agents. PEGylation is effective in improving stability and circulation time of nanoparticles, but it decreases cellular uptake efficiency. Therefore, we developed a smart nano-drug delivery system with PEG deshielding and charge reversal triggered by external light irradiation, which enhances tumor selectivity and penetration and combines photodynamic therapy and chemotherapy for improved tumor treatment effects.
Article
Engineering, Environmental
Zining Hao, Yuchu He, Jing Wang, Xuwu Zhang, Fei Ye, Ze Guan, Xiaokang Liu, Zhenhe Ma, Yi Yuan, Hongming Lou, Dawei Gao
Summary: A rational strategy based on near-infrared light-stimuli enzymolysis and photocatalysis is proposed to decompose tumor interstitial solid and fluid phases, greatly enhancing the tumor penetration of nanomedicine and achieving significant therapeutic effects in anti-tumor treatments.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Chen Yunna, Hu Mengru, Wang Fengling, Wang Lei, Chen Weidong
Summary: Nanoparticles face limitations in treating solid tumors, especially desmoplastic tumors, due to obstruction from the tumor matrix hindering their delivery. Eliminating tumor-associated fibroblasts (TAFs) has become a crucial strategy to overcome this challenge in treating solid tumors.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Oncology
Esther Schoutrop, Lidia Moyano-Galceran, Stephanie Lheureux, Jonas Mattsson, Kaisa Lehti, Hanna Dahlstrand, Isabelle Magalhaes
Summary: This article summarizes the current knowledge on the development and metastatic progression of ovarian cancer, with a specific focus on the characteristics and functions of the immunosuppressive tumor microenvironment. Additionally, current and future treatment modalities are discussed, and an overview of different experimental models used for developing novel therapies is provided.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Instruments & Instrumentation
Jun-Yong Wu, Jia-Xin Cai, Yong-Jiang Li, Xiong-Bin Hu, Xin-Yi Liu, Jie-Min Wang, Tian-Tian Tang, Da-Xiong Xiang
Summary: The study successfully prepared an oil-in-water microemulsion loaded with BTM for transdermal therapy of melanoma. The microemulsion can penetrate the skin, increase the retention of BTM in the epidermis, and effectively suppress tumor growth when combined with Taxol, while also having lower toxicity to normal organs. This combination therapy shows potential for skin cancer therapy.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jun-Yong Wu, Yong-Jiang Li, Xiong-Bin Hu, Si Huang, Da-Xiong Xiang
Summary: Storage temperature and duration significantly impact the stability of sEVs, leading to changes in size distribution, quantity, contents, cellular uptake, and biodistribution. It is suggested to choose the appropriate storage temperature based on the requirements of the study.
Article
Chemistry, Multidisciplinary
Jun-Yong Wu, Yong-Jiang Li, Xiong-Bin Hu, Si Huang, Shilin Luo, Tiantian Tang, Da-Xiong Xiang
Summary: The study compared Exos and BNVs for brain tumor drug delivery, finding that BNVs derived from brain-derived endothelial cells are a promising alternative with higher yield and similar drug-loading capacity to natural exosomes. Despite different mechanisms, BNV/DOX showed similar therapeutic effects to Exo/DOX in inhibiting the progression of glioblastoma, with minimal systemic toxicity. The findings suggest that autologous BNVs are an effective alternative to Exos for brain tumor nanomedicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Medicinal
Quhui Wu, Huiping Ou, Yan Shang, Xi Zhang, Junyong Wu, Fuyuan Fan
Summary: Curcumin, derived from turmeric, shows potential in inhibiting tumor growth and metastasis in lung cancer treatment, especially in combination with chemotherapy drugs and targeted therapies. Utilizing nanotechnology to encapsulate curcumin may help overcome limitations in its clinical applications.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Nanoscience & Nanotechnology
Jia-Xin Cai, Ji-Hua Liu, Jun-Yong Wu, Yong-Jiang Li, Xiao-Han Qiu, Wen-Jie Xu, Ping Xu, Da-Xiong Xiang
Summary: This study developed a targeted nano-carrier and evaluated its anti-cancer efficacy both in vitro and in vivo. The results demonstrated that the nano-carrier successfully delivered the drug to osteosarcoma cells and exhibited significant anti-cancer effects, while causing minimal damage to normal tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jing Wen, Elizabeth B. Moloney, Aoife Canning, Ellen Donohoe, Thomas Ritter, Jiemin Wang, Daxiong Xiang, Junyong Wu, Yongjiang Li
Summary: Nanotechnology offers potential to improve the treatment of autoimmune diseases by reducing side effects and enhancing immunosuppressive capacity. This review discusses the properties and mechanisms of synthesized nanoparticles, biomimetic nanoparticles, and extracellular vesicles, and their immunomodulation properties. The challenges faced by these nanoparticles are also described.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jun-Yong Wu, Yong-Jiang Li, Jiemin Wang, Xiong-Bin Hu, Si Huang, Shilin Luo, Da-Xiong Xiang
Summary: The multifunctional DTX@Ang-EM significantly inhibit the growth of orthotopic GBM with reduced side effects of chemotherapy, providing a new strategy for targeted brain drug delivery and GBM therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Instruments & Instrumentation
Wen-Jie Xu, Jia-Xin Cai, Yong-Jiang Li, Jun-Yong Wu, Daxiong Xiang
Summary: Nanoparticle drug delivery systems have shown promise in efficient drug delivery. Recent studies have highlighted the potential use of macrophage-derived vesicles for drug delivery, due to their chemotactic migration ability and high biocompatibility.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Min Zhou, Yong-Jiang Li, Yu-Cheng Tang, Xin-Yan Hao, Wen-Jie Xu, Da-Xiong Xiang, Jun-Yong Wu
Summary: Extracellular vesicles (EVs), including apoptotic bodies (ABs), have emerged as promising candidates for various biomedical applications. ABs, derived from parent cells during the final stages of apoptosis, possess diverse sources and stable morphological features. They accommodate more functional biomolecules due to their larger volume and exhibit advantageous interactions with recipient cells through their predominant body surface ratio. ABs hold great potential in modulating and alleviating symptoms of numerous diseases, and have also been applied in disease diagnosis, immunotherapy, regenerative therapy, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Yongjiang Li, Junyong Wu, Xiaohan Qiu, Suhe Dong, Jun He, Jihua Liu, Wenjie Xu, Si Huang, Xiongbin Hu, Da-Xiong Xiang
Summary: This study demonstrates the potential of using OMVs as antitumor therapeutics. By co-loading photosensitizer and chemotherapeutic drugs into OMVs and enhancing tumor-targeting ability through macrophage-mediated delivery, a combination of photodynamic therapy, chemotherapy, and immunotherapy can be achieved, effectively eradicating breast tumors and preventing tumor metastasis.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Anyao Bi, Junyong Wu, Shuai Huang, Yongjiang Li, Fan Zheng, Jipeng Ding, Jie Dong, Daxiong Xiang, Wenbin Zeng
Summary: This study reported a novel near-infrared fluorescence probe HBAE for monitoring endogenous BACE1 in AD model mice. High resolution images showed specific red fluorescence staining in the hippocampus region, reflecting different levels of BACE1. This research provides a promising approach for functional insights from protein BACE1 in vivo.
BIOMATERIALS RESEARCH
(2022)
Article
Engineering, Biomedical
Yichu Nie, Wei Chen, Yong Kang, Xue Yuan, Yongjiang Li, Jun Zhou, Wei Tao, Xiaoyuan Ji
Summary: This study presents a nanocatalyst platform (Arg@VMT@PDA-PEG) based on ultrasound-mediated and two-dimensional porous vermiculite nanosheets (VMT NSs), which synergistically harnesses Fenton reaction-based chemodynamic therapy (CDT), 2D semiconductor-based sonodynamic therapy (SDT), and nitric oxide (NO)-based gas therapy for combination cancer therapy.
Article
Chemistry, Multidisciplinary
Wei Chen, Yongjiang Li, Chuang Liu, Yong Kang, Duotian Qin, Shuying Chen, Jun Zhou, Hai-Jun Liu, Bijan Emiliano Ferdows, Dylan Neal Patel, Xiangang Huang, Seyoung Koo, Na Kong, Xiaoyuan Ji, Yihai Cao, Wei Tao, Tian Xie
Summary: This study reports an innovative nanodrug-delivering-drug strategy utilizing two-dimensional stanene-based nanosheets (STNSP) and beta-Elemene (ELE) to overcome TAM-mediated immunosuppression in solid tumors. The results demonstrate that STNSP and ELE can polarize tumor-supportive M2-like TAMs into tumor-suppressive M1-like phenotype and enhance the antitumor response. This research not only shows the immune-modulatory capabilities of the STNSP@ELE chemo-immunotherapeutic nanoplatform in overcoming TAM-mediated immunosuppression but also highlights its potential in developing other nanoimmunotherapeutics for treating immunosuppressive tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Engineering, Biomedical
Si Huang, Xin-Yan Hao, Yong-Jiang Li, Jun-Yong Wu, Da-Xiong Xiang, Shilin Luo
Summary: In this article, a review of current nonviral delivery strategies for antisense oligonucleotides (ASOs) is provided, including modifications, action mechanisms, and multi-carrier methods. The irreplaceable role of nonviral vectors in the progressive development of ASOs delivery is emphasized.
BIOMATERIALS RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Chan Feng, Yongjiang Li, Bijan Emiliano Ferdows, Dylan Neal Patel, Jiang Ouyang, Zhongmin Tang, Na Kong, Enguo Chen, Wei Tao
Summary: Vaccination is a crucial medical milestone in human development, and nanotechnology holds great potential in vaccine development, not only in preventing infectious diseases but also in cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2022)