Degradation-Regulatable Architectured Implantable Macroporous Scaffold for the Spatiotemporal Modulation of Immunosuppressive Microenvironment and Enhanced Combination Cancer Immunotherapy

STINGel: Controlled release of a cyclic dinucleotide for enhanced cancer immunotherapy

(2018) David G. Leach et al.   BIOMATERIALS

Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases

(2018) Chun Gwon Park et al.   Science Translational Medicine

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

(2018) Tingting Wang et al.   Nature Communications

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

More than a scaffold: Stromal modulation of tumor immunity

(2016) Anna Johansson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally

(2016) M. Angela Aznar et al.   JOURNAL OF IMMUNOLOGY

Materials and methods for delivery of biological drugs

(2016) Alexander N. Zelikin et al.   Nature Chemistry

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

TLR7-based cancer immunotherapy decreases intratumoral myeloid-derived suppressor cells and blocks their immunosuppressive function

(2016) Thibaud Spinetti et al.   OncoImmunology

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Engineered in-situ depot-forming hydrogels for intratumoral drug delivery

(2015) Amir Fakhari et al.   JOURNAL OF CONTROLLED RELEASE

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Injectable, Pore-Forming Hydrogels for In Vivo Enrichment of Immature Dendritic Cells

(2015) Catia S. Verbeke et al.   Advanced Healthcare Materials

Poly (γ-glutamic acid) based combination of water-insoluble paclitaxel and TLR7 agonist for chemo-immunotherapy

(2014) Anushree Seth et al.   BIOMATERIALS

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

TLR Ligands in the Local Treatment of Established Intracerebral Murine Gliomas

(2014) O. M. Grauer et al.   JOURNAL OF IMMUNOLOGY

Biopolymer implants enhance the efficacy of adoptive T-cell therapy

(2014) Sirkka B Stephan et al.   NATURE BIOTECHNOLOGY

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

(2014) Jaeyun Kim et al.   NATURE BIOTECHNOLOGY

Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells

(2014) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Nanoparticle mediated co-delivery of paclitaxel and a TLR-4 agonist results in tumor regression and enhanced immune response in the tumor microenvironment of a mouse model

(2013) Aniruddha Roy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

(2013) Aurélien Marabelle et al.   JOURNAL OF CLINICAL INVESTIGATION

Macroscale delivery systems for molecular and cellular payloads

(2013) Cathal J. Kearney et al.   NATURE MATERIALS

Combined Targeting of Costimulatory (OX40) and Coinhibitory (CTLA-4) Pathways Elicits Potent Effector T Cells Capable of Driving Robust Antitumor Immunity

(2013) W. L. Redmond et al.   Cancer Immunology Research

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Changes in the local tumor microenvironment in recurrent cancers may explain the failure of vaccines after surgery

(2012) J. Predina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyaluronic acid-based hydrogels: from a natural polysaccharide to complex networks

(2012) Xian Xu et al.   Soft Matter

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models

(2011) J D Predina et al.   CANCER GENE THERAPY

The impact of antibodies on clinical outcomes in diseases treated with therapeutic protein: Lessons learned from infantile Pompe disease

(2011) Suhrad G. Banugaria et al.   GENETICS IN MEDICINE

Adoptive immunotherapy for postoperative hepatocellular carcinoma: a systematic review

(2011) J.-H. Zhong et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Alginate: Properties and biomedical applications

(2011) Kuen Yong Lee et al.   PROGRESS IN POLYMER SCIENCE

Topical imiquimod treatment of aciclovir-resistant herpes simplex disease: case series and literature review

(2011) N. Perkins et al.   SEXUALLY TRANSMITTED INFECTIONS

Local and Systemic Recurrence is the Achilles Heel of Cancer Surgery

(2010) Louis A. Aliperti et al.   ANNALS OF SURGICAL ONCOLOGY

Intratumoral Immunotherapy of Established Solid Tumors With Chitosan/IL-12

(2010) David A. Zaharoff et al.   JOURNAL OF IMMUNOTHERAPY

Comparison of anti-tumor efficacy of paclitaxel delivered in nano- and microparticles

(2009) Sudhir S. Chakravarthi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Canine neutrophil dysfunction caused by downregulation of β2-integrin expression without mutation

(2009) Saori Kobayashi et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL