Participation of Single-Nucleotide Variants in IFNAR1 and IFNAR2 in the Immune Response against SARS-CoV-2 Infection: A Systematic Review

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

(2023) Ryuya Edahiro et al.   NATURE GENETICS

A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes

(2022) Paul Bastard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

(2022) Christopher J.A. Duncan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

(2022) Julie E. Horowitz et al.   NATURE GENETICS

The immunology and immunopathology of COVID-19

(2022) Miriam Merad et al.   SCIENCE

An Evolutionary Insight Into the Heterogeneous Severity Pattern of the SARS-CoV-2 Infection

(2022) Rabail Zehra Raza et al.   Frontiers in Genetics

Detailed stratified GWAS analysis for severe COVID-19 in four European populations

(2022) Frauke Degenhardt et al.   HUMAN MOLECULAR GENETICS

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

(2022) Qian Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Individual and Synergistic Anti-Coronavirus Activities of SOCS1/3 Antagonist and Interferon α1 Peptides

(2022) Chulbul M. Ahmed et al.   Frontiers in Immunology

IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19

(2022) Ingrid Fricke-Galindo et al.   Frontiers in Immunology

Synthetic mimetics assigned a major role to IFNAR2 in type I interferon signaling

(2022) Nele Zoellner et al.   Frontiers in Microbiology

Host Genetic Risk Factors Associated with COVID-19 Susceptibility and Severity in Vietnamese

(2022) Vu Phuong Nhung et al.   Genes

Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19

(2022) Cristine Dieter et al.   Genes

Targeted screening of genetic associations with COVID-19 susceptibility and severity

(2022) Ping Li et al.   Frontiers in Genetics

Innate immune and inflammatory responses to SARS-CoV-2: implications for COVID-19

(2021) Shea A. Lowery et al.   Cell Host & Microbe

Integrative Genomics Analysis Reveals a 21q22.11 Locus Contributing Risk to COVID-19

(2021) Yunlong Ma et al.   HUMAN MOLECULAR GENETICS

Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19

(2021) Liam Gaziano et al.   NATURE MEDICINE

Genetics Insight for COVID-19 Susceptibility and Severity: A Review

(2021) Ingrid Fricke-Galindo et al.   Frontiers in Immunology

Deleterious single nucleotide polymorphisms (SNPs) of human IFNAR2 gene facilitate COVID-19 severity in patients: a comprehensive in silico approach

(2021) Shamima Akter et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The role of type I interferon in the treatment of COVID‐19

(2021) Fatemeh Sodeifian et al.   JOURNAL OF MEDICAL VIROLOGY

Loss-of-function mutations in IFNAR2 in COVID-19 severe infection susceptibility

(2021) Sandra P. Smieszek et al.   Journal of Global Antimicrobial Resistance

A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19

(2021) Shaghayegh Khanmohammadi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Host cell-intrinsic innate immune recognition of SARS-CoV-2

(2021) Emily A Madden et al.   Current Opinion in Virology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

COVID-19 and emerging viral infections: The case for interferon lambda

(2020) Ludmila Prokunina-Olsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial

(2020) Ivan Fan-Ngai Hung et al.   LANCET

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

(2020) Abigail Vanderheiden et al.   JOURNAL OF VIROLOGY

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Deciphering the Role of Host Genetics in Susceptibility to Severe COVID-19

(2020) Madalina Elena Carter-Timofte et al.   Frontiers in Immunology

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

(2020) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

Characteristics of SARS-CoV-2 and COVID-19

(2020) Ben Hu et al.   NATURE REVIEWS MICROBIOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Genetic Lesions of Type I Interferon Signalling in Human Antiviral Immunity

(2020) Christopher J.A. Duncan et al.   TRENDS IN GENETICS

Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2

(2020) Idoia Busnadiego et al.   mBio

IFNAR2 Deficiency Causing Dysregulation of NK Cell Functions and Presenting With Hemophagocytic Lymphohistiocytosis

(2020) Chiara Passarelli et al.   Frontiers in Genetics

Mendelian randomization analysis identified genes pleiotropically associated with the risk and prognosis of COVID-19

(2020) Di Liu et al.   JOURNAL OF INFECTION

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines

(2019) Nicholas Hernandez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

(2017) Nicole A. de Weerd et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Functional IFNL4 ,IFNLR1 ,IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population

(2017) N. Ma et al.   JOURNAL OF VIRAL HEPATITIS

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker

(2016) Teresa Órpez-Zafra et al.   Multiple Sclerosis Journal

Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker

(2016) Teresa Órpez-Zafra et al.   Multiple Sclerosis Journal

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

(2015) Sophia Davidson et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Human IFNAR2 deficiency: Lessons for antiviral immunity

(2015) Christopher J. A. Duncan et al.   Science Translational Medicine

Role of Differential Expression of Interferon Receptor Isoforms on the Response of Multiple Sclerosis Patients to Therapy with Interferon Beta

(2010) Francesca Gilli   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial

(2009) Tania Mara Welzel et al.   HEPATOLOGY

Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients

(2009) M. Wada et al.   JOURNAL OF VIRAL HEPATITIS