Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

(2021) Janie F. Shelton et al.   NATURE GENETICS

Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals

(2021) Jack A. Kosmicki et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Computationally efficient whole-genome regression for quantitative and binary traits

(2021) Joelle Mbatchou et al.   NATURE GENETICS

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

Presumed Asymptomatic Carrier Transmission of COVID-19

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Clinical Characteristics of Coronavirus Disease 2019 in China

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

(2020) Matthew J Cummings et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility — King County, Washington, March 2020

(2020) Anne Kimball et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Expression of SARS-CoV-2 receptor, ACE2, and TMPRSS2 in the lung airways is lower in children compared to adults and increases due to smoking and COPD

(2020) Narjes Saheb Sharif-Askari et al.   Molecular Therapy-Methods & Clinical Development

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

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Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

(2020) Hugo Zeberg et al.   NATURE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

The GTEx Consortium atlas of genetic regulatory effects across human tissues

(2020)   SCIENCE

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes

(2019) Joseph Park et al.   GENETICS IN MEDICINE

Intracellular signalling pathways and cytoskeletal functions converge on the psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes

(2018) Mari H. Tervaniemi et al.   BMC GENOMICS

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Limited statistical evidence for shared genetic effects of eQTLs and autoimmune-disease-associated loci in three major immune-cell types

(2017) Sung Chun et al.   NATURE GENETICS

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

(2017) Manuel A Ferreira et al.   NATURE GENETICS

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

(2017) Ye Cui et al.   PLoS Pathogens

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

(2016) Frederick E. Dewey et al.   SCIENCE

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

(2015) Bjarni J. Vilhjálmsson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

(2014) Raphael N. Vuille-dit-Bille et al.   AMINO ACIDS

CCHCR1 interacts with EDC4, suggesting its localization in P-bodies

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A genome-wide association study identified new variants associated with the risk of chronic hepatitis B

(2013) Yoon Jun Kim et al.   HUMAN MOLECULAR GENETICS

Genetic interplay between HLA-C and MIR148A in HIV control and Crohn disease

(2013) S. Kulkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of HLA-C Expression Level on HIV Control

(2013) R. Apps et al.   SCIENCE

STAR: ultrafast universal RNA-seq aligner

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Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease

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A scaling normalization method for differential expression analysis of RNA-seq data

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How Many Genetic Variants Remain to Be Discovered?

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