Host cell-intrinsic innate immune recognition of SARS-CoV-2

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

(2021) Armin Bayati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms

(2021) Nicholas C. Huston et al.   MOLECULAR CELL

MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells

(2021) Xin Yin et al.   Cell Reports

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

(2021) Wenjing Wang et al.   Cellular & Molecular Immunology

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

(2021) Antoine Rebendenne et al.   JOURNAL OF VIROLOGY

Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?

(2021) Dominic L. Sykes et al.   LUNG

Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis

(2021) Adam Booth et al.   PLoS One

Sarbecovirus ORF6 proteins hamper the induction of interferon signaling

(2021) Izumi Kimura et al.   Cell Reports

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

(2021) Chiara Fallerini et al.   eLife

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

(2021) Grant R. Campbell et al.   iScience

COVID-19 vaccine challenges: What have we learned so far and what remains to be done?

(2021) Rebecca Forman et al.   HEALTH POLICY

Activation of STING signaling pathway effectively blocks human coronavirus infection

(2021) Wei Liu et al.   JOURNAL OF VIROLOGY

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

(2021) Bingyu Yan et al.   JOURNAL OF VIROLOGY

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells

(2021) Taisho Yamada et al.   NATURE IMMUNOLOGY

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

(2021) Manuel Hayn et al.   Cell Reports

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection

(2021) Na Li et al.   Cell Reports

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

(2021) GuanQun Liu et al.   Nature Microbiology

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection

(2021) Fiachra Humphries et al.   Science Immunology

Pharmacological activation of STING blocks SARS-CoV-2 infection

(2021) Minghua Li et al.   Science Immunology

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

(2021) Lucy G Thorne et al.   EMBO JOURNAL

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

(2021) Sebastian J Theobald et al.   EMBO Molecular Medicine

The janus-kinase inhibitor ruxolitinib in SARS-CoV-2 induced acute respiratory distress syndrome (ARDS)

(2021) Andreas Neubauer et al.   LEUKEMIA

Tofacitinib in Patients Hospitalized with Covid-19 Pneumonia

(2021) Patrícia O. Guimarães et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

(2021) Christine Vazquez et al.   PLoS One

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

(2021) Jack Chun-Chieh Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

(2021) Maria Clara Saad Menezes et al.   Scientific Reports

The RNA sensor MDA5 detects SARS-CoV-2 infection

(2021) Natalia G. Sampaio et al.   Scientific Reports

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

(2021) Maritza Puray-Chavez et al.   Cell Reports

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

(2021) Xavier Solanich et al.   Frontiers in Immunology

RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses

(2021) Takahisa Kouwaki et al.   Frontiers in Immunology

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

SARS-CoV-2–associated ssRNAs activate inflammation and immunity via TLR7/8

(2021) Valentina Salvi et al.   JCI Insight

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection

(2021) Deeksha Munnur et al.   NATURE IMMUNOLOGY

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

An interactive web-based dashboard to track COVID-19 in real time

(2020) Ensheng Dong et al.   LANCET INFECTIOUS DISEASES

N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I

(2020) Mijia Lu et al.   Nature Microbiology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

(2020) Jian Shang et al.   PLoS Pathogens

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

(2020) Keshav K. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

LY6E Restricts the Entry of Human Coronaviruses, Including the Currently Pandemic SARS-CoV-2

(2020) Xuesen Zhao et al.   JOURNAL OF VIROLOGY

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

LY6E impairs coronavirus fusion and confers immune control of viral disease

(2020) Stephanie Pfaender et al.   Nature Microbiology

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

(2020) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

(2020) Timothy N. Hoang et al.   CELL

A Crisp(r) New Perspective on SARS-CoV-2 Biology

(2020) Adam L. Bailey et al.   CELL

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

(2020) Andre C. Kalil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

ISG15 in antiviral immunity and beyond

(2018) Yi-Chieh Perng et al.   NATURE REVIEWS MICROBIOLOGY

LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step

(2018) Katrina B. Mar et al.   Nature Communications

Interferon-inducible LY6E Protein Promotes HIV-1 Infection

(2017) Jingyou Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dengue virus activates cGAS through the release of mitochondrial DNA

(2017) Bo Sun et al.   Scientific Reports

Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

(2016) Sheryl Coutermarsh-Ott et al.   JOURNAL OF GENERAL VIROLOGY

RNAs Containing Modified Nucleotides Fail To Trigger RIG-I Conformational Changes for Innate Immune Signaling

(2016) Ann Fiegen Durbin et al.   mBio

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

SARS coronavirus and innate immunity

(2007) Matthew Frieman et al.   VIRUS RESEARCH