Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling
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Title
Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling
Authors
Keywords
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Journal
Frontiers of Medicine
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-10-23
DOI
10.1007/s11684-023-1010-1
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Note: Only part of the references are listed.- Tumor-Derived Exosomes in Tumor-Induced Immune Suppression
- (2022) Qiongyu Hao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
- (2022) Shih-Ching Lin et al. Nature Protocols
- Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia
- (2021) Michelle J. Cox et al. MOLECULAR THERAPY
- Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy
- (2021) Elise A. Chong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy
- (2021) Gregory M Chen et al. Cancer Discovery
- CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
- (2021) Jay Y. Spiegel et al. NATURE MEDICINE
- Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy
- (2021) Xianhui Chen et al. Molecular Therapy-Oncolytics
- CD70‐targeting CAR‐T cells have potential activity against CD19‐negative B‐cell Lymphoma
- (2021) Wenhai Deng et al. Cancer Communications
- CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles
- (2021) Marine Aitamer et al. BRITISH JOURNAL OF CANCER
- CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial
- (2021) Shaun Cordoba et al. NATURE MEDICINE
- Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment
- (2021) Feiya Ma et al. Journal for ImmunoTherapy of Cancer
- Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy
- (2020) Solin Ali et al. Frontiers in Immunology
- Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer
- (2020) Tanja Stüber et al. Journal for ImmunoTherapy of Cancer
- CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma
- (2020) Hui Liu et al. CLINICAL CANCER RESEARCH
- Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
- (2019) Mauro Poggio et al. CELL
- Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
- (2019) Ladan Mashouri et al. Molecular Cancer
- Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation
- (2019) Iva Xhangolli et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains
- (2018) Julia Proff et al. Journal of Translational Medicine
- Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
- (2018) Christopher C. Kloss et al. MOLECULAR THERAPY
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo
- (2018) Zhenzhen Chen et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia
- (2018) Elena J. Orlando et al. NATURE MEDICINE
- Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready?
- (2016) Michael Boyiadzis et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- TGF 1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
- (2016) B. V. Park et al. Cancer Discovery
- Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor
- (2015) James N. Kochenderfer et al. JOURNAL OF CLINICAL ONCOLOGY
- Exosome mediated communication within the tumor microenvironment
- (2015) Lara Milane et al. JOURNAL OF CONTROLLED RELEASE
- Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy
- (2015) E. Sotillo et al. Cancer Discovery
- Expression of B-Cell Surface Antigens in Subpopulations of Exosomes Released From B-Cell Lymphoma Cells
- (2014) Morten P. Oksvold et al. CLINICAL THERAPEUTICS
- Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1
- (2011) M. J. Szczepanski et al. HAEMATOLOGICA
- Tumor-Derived Exosomes Confer Antigen-Specific Immunosuppression in a Murine Delayed-Type Hypersensitivity Model
- (2011) Chenjie Yang et al. PLoS One
- Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3
- (2011) T. Aung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression
- (2009) A. K. Ghosh et al. BLOOD
- Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes
- (2009) E. U. Wieckowski et al. JOURNAL OF IMMUNOLOGY
- TGF- and 'Adaptive' Foxp3+ Regulatory T cells
- (2009) W. Chen et al. Journal of Molecular Cell Biology
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