Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β signaling

Tumor-Derived Exosomes in Tumor-Induced Immune Suppression

(2022) Qiongyu Hao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning

(2022) Shih-Ching Lin et al.   Nature Protocols

Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia

(2021) Michelle J. Cox et al.   MOLECULAR THERAPY

Five-Year Outcomes for Refractory B-Cell Lymphomas with CAR T-Cell Therapy

(2021) Elise A. Chong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative bulk and single-cell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of CAR T-cell therapy

(2021) Gregory M Chen et al.   Cancer Discovery

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

(2021) Jay Y. Spiegel et al.   NATURE MEDICINE

Secretion of bispecific protein of anti-PD-1 fused with TGF-β trap enhances antitumor efficacy of CAR-T cell therapy

(2021) Xianhui Chen et al.   Molecular Therapy-Oncolytics

CD70‐targeting CAR‐T cells have potential activity against CD19‐negative B‐cell Lymphoma

(2021) Wenhai Deng et al.   Cancer Communications

CD20 expression, TrkB activation and functional activity of diffuse large B cell lymphoma-derived small extracellular vesicles

(2021) Marine Aitamer et al.   BRITISH JOURNAL OF CANCER

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

(2021) Shaun Cordoba et al.   NATURE MEDICINE

Emerging role of tumor-derived extracellular vesicles in T cell suppression and dysfunction in the tumor microenvironment

(2021) Feiya Ma et al.   Journal for ImmunoTherapy of Cancer

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4+ CAR T Cell Efficacy

(2020) Solin Ali et al.   Frontiers in Immunology

Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer

(2020) Tanja Stüber et al.   Journal for ImmunoTherapy of Cancer

CD19-Specific CAR-T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor is Effective in Patients with PD-L1 Positive B-Cell Lymphoma

(2020) Hui Liu et al.   CLINICAL CANCER RESEARCH

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Single-cell Analysis of CAR-T Cell Activation Reveals A Mixed TH1/TH2 Response Independent of Differentiation

(2019) Iva Xhangolli et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

(2018) Julia Proff et al.   Journal of Translational Medicine

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

(2018) Christopher C. Kloss et al.   MOLECULAR THERAPY

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

Dual effect of DLBCL-derived EXOs in lymphoma to improve DC vaccine efficacy in vitro while favor tumorgenesis in vivo

(2018) Zhenzhen Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Genetic mechanisms of target antigen loss in CAR19 therapy of acute lymphoblastic leukemia

(2018) Elena J. Orlando et al.   NATURE MEDICINE

Plasma-derived exosomes in acute myeloid leukemia for detection of minimal residual disease: are we ready?

(2016) Michael Boyiadzis et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

TGF 1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

(2016) B. V. Park et al.   Cancer Discovery

Chemotherapy-Refractory Diffuse Large B-Cell Lymphoma and Indolent B-Cell Malignancies Can Be Effectively Treated With Autologous T Cells Expressing an Anti-CD19 Chimeric Antigen Receptor

(2015) James N. Kochenderfer et al.   JOURNAL OF CLINICAL ONCOLOGY

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

(2015) E. Sotillo et al.   Cancer Discovery

Expression of B-Cell Surface Antigens in Subpopulations of Exosomes Released From B-Cell Lymphoma Cells

(2014) Morten P. Oksvold et al.   CLINICAL THERAPEUTICS

Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor- 1

(2011) M. J. Szczepanski et al.   HAEMATOLOGICA

Tumor-Derived Exosomes Confer Antigen-Specific Immunosuppression in a Murine Delayed-Type Hypersensitivity Model

(2011) Chenjie Yang et al.   PLoS One

Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

(2011) T. Aung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression

(2009) A. K. Ghosh et al.   BLOOD

Tumor-Derived Microvesicles Promote Regulatory T Cell Expansion and Induce Apoptosis in Tumor-Reactive Activated CD8+ T Lymphocytes

(2009) E. U. Wieckowski et al.   JOURNAL OF IMMUNOLOGY

TGF-  and 'Adaptive' Foxp3+ Regulatory T cells

(2009) W. Chen et al.   Journal of Molecular Cell Biology