TCM, brain function and drug space

β-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice

(2014) Yunbo Chen et al.   BRAIN RESEARCH

Gastrodin Inhibits Glutamate-Induced Apoptosis of PC12 Cells via Inhibition of CaMKII/ASK-1/p38 MAPK/p53 Signaling Cascade

(2014) Genling Jiang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective Effects of 3,6′-Disinapoyl Sucrose Through Increased BDNF Levels and CREB Phosphorylation via the CaMKII and ERK1/2 Pathway

(2014) Yuan Hu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effects and mechanisms of ginseng and ginsenosides on cognition

(2014) Imogen Smith et al.   NUTRITION REVIEWS

Saponins in the genus Panax L. (Araliaceae): A systematic review of their chemical diversity

(2014) Wen-zhi Yang et al.   PHYTOCHEMISTRY

Effects of several quinones on insulin aggregation

(2014) Hao Gong et al.   Scientific Reports

A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases

(2014) Chang Ho Lee et al.   Journal of Ginseng Research

Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors

(2014) Seung-Yeol Nah   Frontiers in Physiology

Protective Effect of Paeoniflorin on Aβ25–35-Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction

(2013) Ke Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pharmacokinetic evaluation of desogestrel as a female contraceptive

(2013) Giovanni Grandi et al.   Expert Opinion on Drug Metabolism & Toxicology

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Neuroprotective Effects of Paeoniflorin, But Not the Isomer Albiflorin, are Associated with the Suppression of Intracellular Calcium and Calcium/Calmodulin Protein Kinase II in PC12 Cells

(2013) Di Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review

(2013) Xiuping Chen et al.   MEDICINAL RESEARCH REVIEWS

Therapeutic Potential of Turmeric in Alzheimer's Disease: Curcumin or Curcuminoids?

(2013) Touqeer Ahmed et al.   PHYTOTHERAPY RESEARCH

A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system

(2013) Hee Jin Kim et al.   Journal of Ginseng Research

β-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy

(2012) Zhen-tao Mo et al.   ACTA PHARMACOLOGICA SINICA

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

Original article Protective effect of paeoniflorin against glutamate-induced neurotoxicity in PC12 cells via Bcl-2/Bax signal pathway

(2012) Rong Sun et al.   FOLIA NEUROPATHOLOGICA

Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway

(2012) Y. Zou et al.   FREE RADICAL RESEARCH

Promotive effect of ginsenoside Rd on proliferation of neural stem cells in vivo and in vitro

(2012) Tian Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cardiovascular Diseases and Panax ginseng: A Review on Molecular Mechanisms and Medical Applications

(2012) Jong-Hoon Kim   Journal of Ginseng Research

Neuroprotective effect of ligustilide against ischaemia-reperfusion injury via up-regulation of erythropoietin and down-regulation of RTP801

(2011) Xiao-mei Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ginsenoside Re: Pharmacological Effects on Cardiovascular System

(2011) Lu Peng et al.   Cardiovascular Therapeutics

Puerarin protects differentiated PC12 cells from H2O2-induced apoptosis through the PI3K/Akt signalling pathway

(2011) Qin Zhang et al.   CELL BIOLOGY INTERNATIONAL

Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity

(2011) Fang-ling Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacokinetics and tissue distribution of 2,3,5,4′-tetrahydroxystilbene-2-O-β-d-glucoside from traditional Chinese medicine Polygonum multiflorum following oral administration to rats

(2011) Guiyuan Lv et al.   JOURNAL OF ETHNOPHARMACOLOGY

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Gastrodin Inhibits Expression of Inducible NO Synthase, Cyclooxygenase-2 and Proinflammatory Cytokines in Cultured LPS-Stimulated Microglia via MAPK Pathways

(2011) Ji-Nan Dai et al.   PLoS One

Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways

(2010) Haiying Zhang et al.   EXPERIMENTAL GERONTOLOGY

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway

(2010) Bi-Yin Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

L-3-n-Butylphthalide Improves Cognitive Impairment and Reduces Amyloid-  in a Transgenic Model of Alzheimer's Disease

(2010) Y. Peng et al.   JOURNAL OF NEUROSCIENCE

Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation

(2010) Xiaobing Li et al.   NEUROSCIENCE LETTERS

Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells

(2010) Gang Wang et al.   NEUROSCIENCE LETTERS

Neurocytoprotective effects of the bioactive constituents of Pueraria thomsonii in 6-hydroxydopamine (6-OHDA)-treated nerve growth factor (NGF)-differentiated PC12 cells

(2010) Chien-Min Lin et al.   PHYTOCHEMISTRY

Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice

(2009) Jung-Hwa Yang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ginseng Compounds: An Update on their Molecular Mechanisms and Medical Applications

(2009) Jian-Ming Lu et al.   Current Vascular Pharmacology

Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism

(2009) Dan Yuan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats

(2009) Shiping Ma et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Simultaneous Determination of Paeoniflorin, Albiflorin and Benzoylpaeoniflorin in Radix Paeoniae Alba by TLC

(2008) Shunjun Xu et al.   CHROMATOGRAPHIA

Developing a Drug-like Natural Product Library⊥

(2008) Ronald J. Quinn et al.   JOURNAL OF NATURAL PRODUCTS

Protective effect of isoflavones from Trifolium pratense on dopaminergic neurons

(2008) Han-Qing Chen et al.   NEUROSCIENCE RESEARCH

High performance liquid chromatography–mass spectrometry analysis for rat metabolism and pharmacokinetic studies of lithospermic acid B from danshen

(2008) Liang Cui et al.   TALANTA

Catalpol attenuates the neurotoxicity induced by β-amyloid1–42 in cortical neuron–glia cultures

(2007) Bo Jiang et al.   BRAIN RESEARCH

Distribution and metabolism of gastrodin in rat brain

(2007) Qiao Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the action of ginsenoside Rh2 against beta-amyloid-induced inhibition of rat brain astrocytes

(2007) Po-Chuen Shieh et al.   NEUROSCIENCE LETTERS

Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion

(2007) Jing-Yan Han et al.   PHARMACOLOGY & THERAPEUTICS