Journal
NEUROSCIENCE LETTERS
Volume 483, Issue 1, Pages 1-5Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.07.027
Keywords
Parkinson's disease; Tetrahydroxystilbene glucoside; MPP+; PC12 cells; Apoptosis; ROS; JNK
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Funding
- National Natural Science Foundation of China [30772743]
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It is known that oxidative stress plays a major role in the progression of Parkinson's disease (PD). Previous studies have suggested that 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), an active component extracted from a traditional Chinese herb Polygonum multiflorum Thunb., has significant antioxidant and free radical-scavenging activities. This is the first study that investigated the protective effects of TSG against MPP+-induced apoptosis in PC12 cells and determined the underlying mechanism. The results showed that incubation of PC12 cells with TSG before exposing them to MPP+ could significantly decrease cell viability loss and reverse cell apoptosis in a dose-dependent manner. The anti-apoptotic effects of TSG were probably mediated via the inhibition of ROS generation and modulation of JNK activation because TSG blocked ROS increase and JNK phosphorylation induced by MPP+. Taken together, these results indicated that TSG may provide a useful therapeutic strategy for the treatment of neurodegenerative diseases such as PD. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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