Review
Biochemistry & Molecular Biology
Atefeh Afsar, Maria del Carmen Chacon Castro, Adedamola Saidi Soladogun, Li Zhang
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by neurofibrillary tangles, amyloid beta plaque deposition, and neurodegeneration. Genetic mutations, inflammation, blood-brain barrier impairment, mitochondrial dysfunction, oxidative stress, and metal ion imbalance are associated with AD progression. Recent studies have shown a link between altered heme metabolism and AD. Understanding the underlying mechanisms and identifying therapeutic targets is crucial for AD drug development. This review discusses common alterations in AD, potential therapeutic targets, mathematical models, and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Huan Wang, Qi Cheng, Lingjie Bao, Mingqing Li, Kaikai Chang, Xiaofang Yi
Summary: Chemoresistance is a major challenge in cancer therapy. Tumor cells have high levels of reactive oxygen species (ROS), making them more susceptible to further ROS increase than normal cells. However, tumor cells can counteract therapy-induced oxidative stress, leading to chemoresistance. Therefore, understanding the cytoprotective mechanisms of tumor cells is necessary to overcome chemoresistance.
Article
Cell Biology
Ok-Joo Sul, Hyo-Jung Hyun, Monisha Rajasekaran, Jae-Hee Suh, Hye-Seon Choi
Summary: The loss of ovarian function leads to increased body weight and fat mass due to decreased adipose tissue browning caused by estrogen deficiency. Exogenous estrogen can reverse this change, while M2 polarization mediated by heme oxygenase-1 can enhance adipose tissue browning.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Food Science & Technology
Yen-Chuan Ou, Jian-Ri Li, Chih-Cheng Wu, Tung-Min Yu, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Yu-Fan Chen, Chun-Jung Chen
Summary: Cadmium induces kidney toxicity through oxidative stress and inflammation. This study investigates the reciprocal crosstalk among oxidative stress, inflammation, and the nuclear Nrf2 pathway in cadmium-induced nephrotoxicity. The results suggest a role for HO-1 as a linking molecule in mediating nephrotoxicity-associated IL-6 expression upon cadmium exposure.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Medicine, Research & Experimental
Samir Kumar Beura, Rishika Dhapola, Abhishek Ramachandra Panigrahi, Pooja Yadav, Dibbanti Harikrishna Reddy, Sunil Kumar Singh
Summary: Alzheimer's disease, a common neurodegenerative disorder, is associated with platelet hyperactivity and ROS generation, which may contribute to disease progression.
Article
Agriculture, Multidisciplinary
Chia-Cheng Wei, Shang-Wei Li, Chia-Tung Wu, Chun Ming How, Min-Hsiung Pan
Summary: This study using a nematode model found that dietary exposure to MG may exacerbate AD pathology, as high levels of MG exposure led to decreased locomotive behaviors, increased A beta protein accumulation, impaired 5-HT reuptake, increased oxidative stress, and disrupted autophagy pathway. Treatment with the citrus flavonoid nobiletin reduced MG-induced toxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Weiqing Zhang, Robert D. Willows, Rui Deng, Zheng Li, Mengqi Li, Yan Wang, Yunling Guo, Weida Shi, Qiuling Fan, Shelley S. Martin, Nathan C. Rockwell, J. Clark Lagarias, Deqiang Duanmu
Summary: The biosynthesis of chlorophyll and heme in oxygenic phototrophs follows a common pathway that diverges with the insertion of magnesium or iron. The interaction of bilins with GENOMES UNCOUPLED 4 (GUN4) stimulates the enzymatic activity of magnesium chelatase (MgCh) and stabilizes the accumulation of protoporphyrin IX-binding CrCHLH1 subunit of MgCh. GUN4: bilin complexes play dual regulatory roles in sustaining bilin biosynthesis and chlorophyll biosynthesis in illuminated oxic environments of all photosynthetic eukaryotes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae, Sung-Joo Park
Summary: Guggulsterone (GS) exerts anti-inflammatory effects by inducing heme oxygenase-1 (HO-1) expression through reactive oxygen species (ROS) production. GS inhibits the expression of inflammatory mediators and prolongs survival in an endotoxemia model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Vaibhav Walia, Deepak Kaushik, Vineet Mittal, Kuldeep Kumar, Ravinder Verma, Jatin Parashar, Rokeya Akter, Md Habibur Rahman, Saurabh Bhatia, Ahmed Al-Harrasi, Chenmala Karthika, Tanima Bhattacharya, Hitesh Chopra, Ghulam Md Ashraf
Summary: Alzheimer's disease is the sixth leading cause of death in elderly patients, characterized by progressive neuronal degeneration and cognitive impairment. Oxidative stress plays a key role in the pathogenesis of AD.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Shih-Kai Chiang, Shuen-Ei Chen, Ling-Chu Chang
Summary: HO-1 plays a significant role in oxidative stress and tumorigenesis, regulating key signaling pathways in the progression of cancer. While the relationship between HO-1 and cancer development has not been thoroughly examined, it holds great potential in advancing research in this area.
Article
Neurosciences
Xiaoda Lu, Yue Zhang, Hongyuan Li, Yushan Jin, Lihui Zhao, Xiaohui Wang
Summary: Nicotine reduces Aβ oligomer formation and alleviates Aβ-induced paralysis of C. elegans, primarily by lowering Aβ deposits and reducing Aβ oligomers. Additionally, nicotine enhances oxidative stress resistance in worms through SKN-1 signaling.
NEUROSCIENCE LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Joerg Fahrer, Simon Wittmann, Ann-Cathrin Wolf, Tina Kostka
Summary: This review highlights the importance of heme oxygenase-1 (HO-1) in the physiology and pathophysiology of the digestive system. It provides an overview of the structure, function, and regulatory mechanisms of HO-1, as well as discussing the similarities and differences with HO-2. The review also explores the cytoprotective and potential pro-inflammatory effects of HO-1 and its breakdown products. Furthermore, it discusses the role of HO-1 in colorectal cancer, focusing on pathways and mechanisms involved in tumor induction and progression.
Review
Biochemistry & Molecular Biology
Yi-Hsuan Wu, Hsi-Lung Hsieh
Summary: The heme oxygenase system, particularly HO-1 and HO-2, plays an important role in the nervous system. Dysregulation of HO-1 is associated with neurodegenerative diseases.