Therapeutic Potential of Turmeric in Alzheimer's Disease: Curcumin or Curcuminoids?

Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease

(2014) Zhang Xiong et al.   Pharmacological Reports

Optimized Turmeric Extract Reduces ?-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice

(2012) R. Douglas Shytle et al.   Current Alzheimer Research

A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease

(2011) Touqeer Ahmed et al.   BRAIN RESEARCH

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrahydrocurcumin confers protection against amyloid β-induced toxicity

(2010) Shilpa Mishra et al.   NEUROREPORT

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices

(2010) Touqeer Ahmed et al.   SYNAPSE

Comparative bioavailability of curcumin, turmeric and Biocurcumax™ in traditional vehicles using non-everted rat intestinal sac model

(2010) Shishu et al.   Journal of Functional Foods

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

(2009) Tsuyoshi Hamaguchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Curcumin enhances non-inflammatory phagocytic activity of RAW264.7 cells

(2009) Kavita Bisht et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)☆

(2009) Tauheed Ishrat et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

(2009) B Antony et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide

(2009) Lijia Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats

(2009) Hongmei Tang et al.   LIFE SCIENCES

Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation

(2009) Yoshiari Shimmyo et al.   NEUROREPORT

Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma

(2009) S. Sharma et al.   NEUROSCIENCE

Curcumin attenuates ethanol-induced toxicity in HT22 hippocampal cells by activating mitogen-activated protein kinase phosphatase-1

(2009) Hyun-Ock Pae et al.   NEUROSCIENCE LETTERS

Consumption of Grape Seed Extract Prevents Amyloid-β Deposition and Attenuates Inflammation in Brain of an Alzheimer’s Disease Mouse

(2009) Yan-Jiang Wang et al.   NEUROTOXICITY RESEARCH

Curcumin attenuates aluminium-induced functional neurotoxicity in rats

(2009) Pallavi Sethi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antidepressant-like effects of curcumin on serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats

(2009) Yu-Cheng Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Increasing aqueous solubility of curcumin for improving bioavailability

(2009) Biji T. Kurien et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetics of Alzheimer's disease: recent advances

(2009) Dimitrios Avramopoulos   Genome Medicine

Curcumin ameliorates impaired insulin/IGF signalling and memory deficit in a streptozotocin-treated rat model

(2008) Ahmet Turan Isik et al.   AGE

Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat

(2008) Preeti Dohare et al.   BEHAVIOURAL BRAIN RESEARCH

Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions

(2008) Deepak Sharma et al.   BIOGERONTOLOGY

Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications

(2008) Wolfgang W Quitschke   BMC BIOTECHNOLOGY

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB

(2008) Rui Wang et al.   BRAIN RESEARCH

Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats

(2008) Jing Zhao et al.   BRAIN RESEARCH

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

(2008) N. Dhillon et al.   CLINICAL CANCER RESEARCH

Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation

(2008) So-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Sodium arsenite induced biochemical perturbations in rats: Ameliorating effect of curcumin

(2008) Mokhtar I. Yousef et al.   FOOD AND CHEMICAL TOXICOLOGY

Ameliorating effect of curcumin on sodium arsenite-induced oxidative damage and lipid peroxidation in different rat organs

(2008) Fatma M. El-Demerdash et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain

(2008) Manisha Rastogi et al.   FREE RADICAL RESEARCH

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Biochemical markers in persons with preclinical familial Alzheimer disease

(2008) J. M. Ringman et al.   NEUROLOGY

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin

(2008) Raozhou Lin et al.   NEUROSCIENCE LETTERS

Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide

(2008) Li Jia Zhang et al.   NEUROSCIENCE LETTERS

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

(2008) Mohit Kumar Bhutani et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease

(2008) Touqeer Ahmed et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Herbal medicine for dementia: a systematic review

(2008) Brian H. May et al.   PHYTOTHERAPY RESEARCH

Antidepressant activity of curcumin: involvement of serotonin and dopamine system

(2008) Shrinivas K. Kulkarni et al.   PSYCHOPHARMACOLOGY

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

(2008) Bharat B. Aggarwal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES