Novel Insights into Osteoclast Energy Metabolism

Identification of Differentially Expressed Genes and Molecular Pathways Involved in Osteoclastogenesis Using RNA-seq

(2023) Sarah Rashid et al.   Genes

CPT1A-Mediated Fatty Acid Oxidation Promotes Precursor Osteoclast Fusion in Rheumatoid Arthritis

(2022) Zhaoyang Huang et al.   Frontiers in Immunology

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

(2022) Bhaba K Das et al.   eLife

Mitochondrial fatty acid β-oxidation is important for normal osteoclast formation in growing female mice

(2022) Priyanka Kushwaha et al.   Frontiers in Physiology

Amino acid metabolism in skeletal cells

(2022) Claire-Sophie Devignes et al.   Bone Reports

Regulation of Osteoclast Differentiation and Activity by Lipid Metabolism

(2021) Haemin Kim et al.   Cells

Membrane Transport Proteins in Osteoclasts: The Ins and Outs

(2021) Amy B. P. Ribet et al.   Frontiers in Cell and Developmental Biology

The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis

(2021) Wacili Da et al.   Frontiers in Endocrinology

Relationships between Slc1a5 and Osteoclastogenesis

(2021) Hideki Tsumura et al.   COMPARATIVE MEDICINE

Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair

(2020) Yasuhito Yahara et al.   NATURE CELL BIOLOGY

Environmental arginine controls multinuclear giant cell metabolism and formation

(2020) Julia S. Brunner et al.   Nature Communications

The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+–NFATc1 axis

(2020) Anna Ballard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation

(2020) Boer Li et al.   FASEB JOURNAL

Dynamin‐related protein 1 positively regulates osteoclast differentiation and bone loss

(2020) Sol Jeong et al.   FEBS LETTERS

PDK2 Deficiency Prevents Ovariectomy‐Induced Bone Loss in Mice by Regulating the RANKL‐NFATc1 Pathway During Osteoclastogenesis

(2020) Ji‐Min Lee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Metabolic reprogramming of osteoclasts represents a therapeutic target during the treatment of osteoporosis

(2020) Jule Taubmann et al.   Scientific Reports

Fructose 1,6-bisphosphate inhibits osteoclastogenesis by attenuating RANKL-induced NF-κB/NFATc-1

(2019) L. Wilches-Buitrago et al.   INFLAMMATION RESEARCH

Developmental origin, functional maintenance and genetic rescue of osteoclasts

(2019) Christian E. Jacome-Galarza et al.   NATURE

The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway

(2019) Kakeru Ozaki et al.   Science Signaling

Metabolic reprogramming in osteoclasts

(2019) Kyung-Hyun Park-Min   Seminars in Immunopathology

Lipids in the Bone Marrow: An Evolving Perspective

(2019) Elizabeth Rendina-Ruedy et al.   Cell Metabolism

Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling

(2019) Jian Zhang et al.   TOXICOLOGY LETTERS

Therapeutic potentials and modulatory mechanisms of fatty acids in bone

(2019) Minyue Bao et al.   CELL PROLIFERATION

Inhibition of PFKFB3 suppresses osteoclastogenesis and prevents ovariectomy‐induced bone loss

(2019) Jia Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesisin vitroandin vivo

(2018) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation

(2018) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

Kynurenine, a Tryptophan Metabolite That Accumulates With Age, Induces Bone Loss

(2017) Mona El Refaey et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα

(2017) Seyeon Bae et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Cell Bioenergetics and Skeletal Energy Homeostasis

(2017) Ryan C. Riddle et al.   PHYSIOLOGICAL REVIEWS

Metabolic properties of the osteoclast

(2017) Timothy R. Arnett et al.   BONE

Glucose metabolism in bone

(2017) Courtney M. Karner et al.   BONE

The Biochemistry and Physiology of Mitochondrial Fatty Acid β-Oxidation and Its Genetic Disorders

(2016) Sander M. Houten et al.   Annual Review of Physiology

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Investigation of proteome changes in osteoclastogenesis in low serum culture system using quantitative proteomics

(2016) Qi Xiong et al.   Proteome Science

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling

(2016) Heejin Ahn et al.   PLoS One

Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation

(2015) Kazuki Inoue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

(2015) Rong Zeng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

(2015) Keizo Nishikawa et al.   NATURE MEDICINE

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

(2015) Takashi Izawa et al.   Cell Reports

Arachidonic Acid and Docosahexaenoic Acid Suppress Osteoclast Formation and Activity in Human CD14+ Monocytes, In vitro

(2015) Abe E. Kasonga et al.   PLoS One

Impact of Dietary Aromatic Amino Acids on Osteoclastic Activity

(2014) Mona El Refaey et al.   CALCIFIED TISSUE INTERNATIONAL

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Characterization of Functional Reprogramming during Osteoclast Development Using Quantitative Proteomics and mRNA Profiling

(2014) Eunkyung An et al.   MOLECULAR & CELLULAR PROTEOMICS

Effects of ω3- and ω6-Polyunsaturated Fatty Acids on RANKL-Induced Osteoclast Differentiation of RAW264.7 Cells: A Comparative in Vitro Study

(2014) Jan Boeyens et al.   Nutrients

Homocysteine alters the osteoprotegerin/RANKL system in the osteoblast to promote bone loss: pivotal role of the redox regulator forkhead O1

(2013) Viji Vijayan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Palmitic Acid and DGAT1 Deficiency Enhance Osteoclastogenesis, while Oleic Acid-Induced Triglyceride Formation Prevents It

(2013) Zoi Drosatos-Tampakaki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

(2013) Karl J Morten et al.   JOURNAL OF PATHOLOGY

Osteoclasts: New Insights

(2013) Feng Xu et al.   Bone Research

Hypercholesterolemia Promotes an Osteoporotic Phenotype

(2012) Kristine Pelton et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption

(2012) Tsuyoshi Miyazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-density Lipoprotein Receptor Deficiency Causes Impaired Osteoclastogenesis and Increased Bone Mass in Mice because of Defect in Osteoclastic Cell-Cell Fusion

(2012) Mari Okayasu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor activator of NF-κB ligand-dependent expression of caveolin-1 in osteoclast precursors, and high dependency of osteoclastogenesis on exogenous lipoprotein

(2011) Naoto Hada et al.   BONE

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

(2011) K. Henriksen et al.   ENDOCRINE REVIEWS

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

Saturated fatty acids enhance osteoclast survival

(2009) So-Ra Oh et al.   JOURNAL OF LIPID RESEARCH

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE