Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesisin vitroandin vivo

Clinical Impact and Cellular Mechanisms of Iron Overload-Associated Bone Loss

(2017) Viktória Jeney   Frontiers in Pharmacology

Effect of testosterone on hepcidin, ferroportin, ferritin and iron binding capacity in patients with hypogonadotropic hypogonadism and type 2 diabetes

(2016) Sandeep Dhindsa et al.   CLINICAL ENDOCRINOLOGY

LIS1 Regulates Osteoclastogenesis through Modulation of M-SCF and RANKL Signaling Pathways and CDC42

(2016) Shiqiao Ye et al.   International Journal of Biological Sciences

SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS

(2016) Haemin Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Thalassemia-associated osteoporosis: a systematic review on treatment and brief overview of the disease

(2016) A. D. Dede et al.   OSTEOPOROSIS INTERNATIONAL

RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival

(2016) T Fujiwara et al.   Cell Death & Disease

NADPH oxidase gp91phox contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1

(2016) In Soon Kang et al.   Scientific Reports

Bone microstructural defects and osteopenia in hemizygous βIVSII-654 knockin thalassemic mice: sex-dependent changes in bone density and osteoclast function

(2015) Kanogwun Thongchote et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Extracellular Iron is a Modulator of the Differentiation of Osteoclast Lineage Cells

(2015) Wenjie Xie et al.   CALCIFIED TISSUE INTERNATIONAL

Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

(2015) Zhimin Gu et al.   CANCER RESEARCH

Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element

(2015) Yi Qian et al.   CELLULAR SIGNALLING

Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass

(2015) Wang Xiao et al.   JOURNAL OF ENDOCRINOLOGY

Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer’s Disease

(2015) Jun-Peng Guo et al.   PLoS One

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload

(2014) Li Sun et al.   GENE

Effects of Mouse Hepcidin 1 Treatment on Osteoclast Differentiation and Intracellular Iron Concentration

(2014) Guo-yang Zhao et al.   INFLAMMATION

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

(2014) Shoshana M. Bartell et al.   Nature Communications

Tmem64 Modulates Calcium Signaling during RANKL-Mediated Osteoclast Differentiation

(2013) Hyunsoo Kim et al.   Cell Metabolism

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

Steap4 Plays a Critical Role in Osteoclastogenesisin Vitroby Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

(2013) Jian Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Keap1/Nrf2 Protein Axis Plays a Role in Osteoclast Differentiation by Regulating Intracellular Reactive Oxygen Species Signaling

(2013) Hiroyuki Kanzaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

(2013) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Advances in the Regulation of Osteoclasts and Osteoclast Functions

(2013) B.F. Boyce   JOURNAL OF DENTAL RESEARCH

The association between higher serum ferritin level and lower bone mineral density is prominent in women ≥45 years of age (KNHANES 2008–2010)

(2013) B.-J. Kim et al.   OSTEOPOROSIS INTERNATIONAL

Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action

(2012) Alfons Lawen et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Mammalian Iron Homeostasis

(2012) Kostas Pantopoulos et al.   BIOCHEMISTRY

Ferroportin-mediated iron transport: Expression and regulation

(2012) Diane M. Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

17β-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site

(2012) Qing Yang et al.   ENDOCRINOLOGY

Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element

(2012) Yanli Hou et al.   GENE

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

5-Lipoxygenase Mediates RANKL-Induced Osteoclast Formation via the Cysteinyl Leukotriene Receptor 1

(2012) J.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

(2012) Peng Jia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Haemochromatosis: The bone and the joint

(2011) Pascal Guggenbuhl et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Signal transduction by reactive oxygen species

(2011) Toren Finkel   JOURNAL OF CELL BIOLOGY

Bone remodelling at a glance

(2011) J. C. Crockett et al.   JOURNAL OF CELL SCIENCE

LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1

(2011) Shiqiao Ye et al.   PLoS One

Role of mitochondrial reactive oxygen species in osteoclast differentiation

(2010) Satish Srinivasan et al.   Annals of the New York Academy of Sciences

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

RANKL-mediated Reactive Oxygen Species Pathway That Induces Long Lasting Ca2+Oscillations Essential for Osteoclastogenesis

(2010) Min Seuk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

(2010) Yuji Ito et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone status in a mouse model of genetic hemochromatosis

(2010) P. Guggenbuhl et al.   OSTEOPOROSIS INTERNATIONAL

The molecular basis of hepcidin-resistant hereditary hemochromatosis

(2009) A. Fernandes et al.   BLOOD

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Recycling Iron in Normal and Pathological States

(2009) Carole Beaumont et al.   SEMINARS IN HEMATOLOGY

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia

(2008) Ellen B. Fung et al.   BONE

Bone Disease in Thalassemia: A Frequent and Still Unresolved Problem

(2008) Maria G Vogiatzi et al.   JOURNAL OF BONE AND MINERAL RESEARCH