Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

Considering Sex as a Biological Variable in Basic and Clinical Studies: An Endocrine Society Scientific Statement

(2021) Aditi Bhargava et al.   ENDOCRINE REVIEWS

Impaired Bone Microarchitecture in Patients with Hereditary Hemochromatosis and Skeletal Complications

(2020) Nico Maximilian Jandl et al.   CALCIFIED TISSUE INTERNATIONAL

Transferrin Receptor 1 Regulates Thermogenic Capacity and Cell Fate in Brown/Beige Adipocytes

(2020) Jin Li et al.   Advanced Science

Both aerobic glycolysis and mitochondrial respiration are required for osteoclast differentiation

(2020) Boer Li et al.   FASEB JOURNAL

The osteoclast cytoskeleton – current understanding and therapeutic perspectives for osteoporosis

(2020) Anne Blangy et al.   JOURNAL OF CELL SCIENCE

Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors

(2020) Ha-Neui Kim et al.   Scientific Reports

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis

(2019) Shufen Wang et al.   HAEMATOLOGICA

From macrophage to osteoclast – How metabolism determines function and activity

(2018) Katharina F. Kubatzky et al.   CYTOKINE

Transferrin and transferrin receptors update

(2018) Hiroshi Kawabata   FREE RADICAL BIOLOGY AND MEDICINE

Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesisin vitroandin vivo

(2018) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation

(2018) Yan Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mouse Cre Models for the Study of Bone Diseases

(2018) Sarah L. Dallas et al.   Current Osteoporosis Reports

Inflammatory osteolysis: a conspiracy against bone

(2017) Gabriel Mbalaviele et al.   JOURNAL OF CLINICAL INVESTIGATION

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

Metabolic properties of the osteoclast

(2017) Timothy R. Arnett et al.   BONE

Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2

(2016) Gautam Rishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS

(2016) Haemin Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Thalassemia-associated osteoporosis: a systematic review on treatment and brief overview of the disease

(2016) A. D. Dede et al.   OSTEOPOROSIS INTERNATIONAL

Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement

(2016) Jawed A. Siddiqui et al.   PHYSIOLOGY

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CathepsinKCre mediated deletion of βcatenin results in dramatic loss of bone mass by targeting both osteoclasts and osteoblastic cells

(2016) Paula Ruiz et al.   Scientific Reports

Lack of α2C-Adrenoceptor Results in Contrasting Phenotypes of Long Bones and Vertebra and Prevents the Thyrotoxicosis-Induced Osteopenia

(2016) Marilia Bianca Cruz Grecco Teixeira et al.   PLoS One

Decreased Ferroportin Promotes Myeloma Cell Growth and Osteoclast Differentiation

(2015) Zhimin Gu et al.   CANCER RESEARCH

Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass

(2015) Wang Xiao et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of mitochondrial morphology and function by stearoylation of TFR1

(2015) Deniz Senyilmaz et al.   NATURE

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis

(2015) Alan C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart

(2015) Wenjing Xu et al.   Cell Reports

Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle

(2015) Tomasa Barrientos et al.   EBioMedicine

Iron Chelation Inhibits Osteoclastic Differentiation In Vitro and in Tg2576 Mouse Model of Alzheimer’s Disease

(2015) Jun-Peng Guo et al.   PLoS One

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

(2014) Clare L. Abram et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Tmem64 Modulates Calcium Signaling during RANKL-Mediated Osteoclast Differentiation

(2013) Hyunsoo Kim et al.   Cell Metabolism

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

Steap4 Plays a Critical Role in Osteoclastogenesisin Vitroby Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

(2013) Jian Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

Mechanisms of Mammalian Iron Homeostasis

(2012) Kostas Pantopoulos et al.   BIOCHEMISTRY

17β-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site

(2012) Qing Yang et al.   ENDOCRINOLOGY

Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element

(2012) Yanli Hou et al.   GENE

Estrogen Regulates Hepcidin Expression via GPR30-BMP6-Dependent Signaling in Hepatocytes

(2012) Yasumasa Ikeda et al.   PLoS One

Membrane Trafficking in Osteoblasts and Osteoclasts: New Avenues for Understanding and Treating Skeletal Diseases

(2012) Haibo Zhao   TRAFFIC

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The osteoclast and its unique cytoskeleton

(2011) Steven L. Teitelbaum   Annals of the New York Academy of Sciences

Severe nutritional iron-deficiency anaemia has a negative effect on some bone turnover biomarkers in rats

(2011) Javier Díaz-Castro et al.   EUROPEAN JOURNAL OF NUTRITION

Role of mitochondrial reactive oxygen species in osteoclast differentiation

(2010) Satish Srinivasan et al.   Annals of the New York Academy of Sciences

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass

(2010) Prashanthi Menon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone status in a mouse model of genetic hemochromatosis

(2010) P. Guggenbuhl et al.   OSTEOPOROSIS INTERNATIONAL

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

The Osteoclast: Friend or Foe?

(2008) Deborah V. Novack et al.   Annual Review of Pathology-Mechanisms of Disease

Fracture prevalence and relationship to endocrinopathy in iron overloaded patients with sickle cell disease and thalassemia

(2008) Ellen B. Fung et al.   BONE

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

(2008) Antonios O. Aliprantis et al.   JOURNAL OF CLINICAL INVESTIGATION

Severe Iron Deficiency Decreases Both Bone Formation and Bone Resorption in Rats

(2008) Shin-ichi Katsumata et al.   JOURNAL OF NUTRITION