Metabolic reprogramming in osteoclasts

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss

(2018) Sébastien Lucas et al.   Nature Communications

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

(2017) Koichi Murata et al.   IMMUNITY

MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα

(2017) Seyeon Bae et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone Size and Quality Regulation: Concerted Actions of mTOR in Mesenchymal Stromal Cells and Osteoclasts

(2017) Hongguang Wu et al.   Stem Cell Reports

Glucose metabolism in bone

(2017) Courtney M. Karner et al.   BONE

Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects

(2016) Wei Wei et al.   Cell Metabolism

Energy metabolism in osteoclast formation and activity

(2016) Silvia Lemma et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inactivation of Regulatory-associated Protein of mTOR (Raptor)/Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Osteoclasts Increases Bone Mass by Inhibiting Osteoclast Differentiation in Mice

(2016) Qinggang Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

(2016) Jau-Yi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling

(2016) Heejin Ahn et al.   PLoS One

Transport of Sugars

(2015) Li-Qing Chen et al.   Annual Review of Biochemistry

The role of osteoclast differentiation and function in skeletal homeostasis

(2015) Kyoji Ikeda et al.   JOURNAL OF BIOCHEMISTRY

Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms

(2015) Rong Zeng et al.   JOURNAL OF BONE AND MINERAL RESEARCH

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

(2015) Keizo Nishikawa et al.   NATURE MEDICINE

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

(2015) Takashi Izawa et al.   Cell Reports

Arachidonic Acid and Docosahexaenoic Acid Suppress Osteoclast Formation and Activity in Human CD14+ Monocytes, In vitro

(2015) Abe E. Kasonga et al.   PLoS One

Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization

(2014) Zixue Jin et al.   Cell Metabolism

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Advances in osteoclast biology reveal potential new drug targets and new roles for osteoclasts

(2013) Brendan F Boyce   JOURNAL OF BONE AND MINERAL RESEARCH

Palmitic Acid and DGAT1 Deficiency Enhance Osteoclastogenesis, while Oleic Acid-Induced Triglyceride Formation Prevents It

(2013) Zoi Drosatos-Tampakaki et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential regulation of HIF-mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts

(2013) Karl J Morten et al.   JOURNAL OF PATHOLOGY

HIF1  is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis

(2013) Y. Miyauchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyunsaturated Fatty Acids and Their Relation with Bone and Muscle Health in Adults

(2013) Kelsey M. Mangano et al.   Current Osteoporosis Reports

Intracellular and Extracellular ATP Coordinately Regulate the Inverse Correlation between Osteoclast Survival and Bone Resorption

(2012) Tsuyoshi Miyazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-density Lipoprotein Receptor Deficiency Causes Impaired Osteoclastogenesis and Increased Bone Mass in Mice because of Defect in Osteoclastic Cell-Cell Fusion

(2012) Mari Okayasu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A two-way street: reciprocal regulation of metabolism and signalling

(2012) Kathryn E. Wellen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

PGC1β Mediates PPARγ Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss

(2010) Wei Wei et al.   Cell Metabolism

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4

(2010) Helen J. Knowles et al.   FASEB JOURNAL

Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine

(2010) Andrew J. Leger et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Proteomic analysis of osteoclast lipid rafts: the role of the integrity of lipid rafts on V-ATPase activity in osteoclasts

(2010) Jiyoon Ryu et al.   JOURNAL OF BONE AND MINERAL METABOLISM

PPARγ in bone homeostasis

(2010) Yihong Wan   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Saturated fatty acids enhance osteoclast survival

(2009) So-Ra Oh et al.   JOURNAL OF LIPID RESEARCH

Acute hypoxia and osteoclast activity: a balance between enhanced resorption and increased apoptosis

(2009) Helen J Knowles et al.   JOURNAL OF PATHOLOGY

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

(2009) Kiyo-aki Ishii et al.   NATURE MEDICINE

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

(2008) Arun Radhakrishnan et al.   Cell Metabolism