Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

The Orexin receptors: Structural and anti-tumoral properties

(2022) Alain Couvineau et al.   Frontiers in Endocrinology

The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment

(2022) Thierry Voisin et al.   Frontiers in Oncology

Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity

(2022) Hiroshi Tsuneki et al.   Cell Reports

Protective Effects of Orexin A in a Murine Model of Cisplatin-Induced Acute Kidney Injury

(2022) Jungmin Jo et al.   Journal of Clinical Medicine

Orexin A Suppresses the Expression of Exosomal PD-L1 in Colon Cancer and Promotes T Cell Activity by Inhibiting JAK2/STAT3 Signaling Pathway

(2021) Jing Wen et al.   DIGESTIVE DISEASES AND SCIENCES

Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target

(2021) Couvineau Alain et al.   MOLECULES

Focus on the Complex Interconnection between Cancer, Narcolepsy and Other Neurodegenerative Diseases: A Possible Case of Orexin-Dependent Inverse Comorbidity

(2021) Maria P. Mogavero et al.   Cancers

Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions

(2021) Alain Couvineau et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder

(2020) Yves Dauvilliers et al.   ANNALS OF NEUROLOGY

Recently Approved and Upcoming Treatments for Narcolepsy

(2020) Michael J. Thorpy   CNS DRUGS

Lemborexant: First Approval

(2020) Lesley J. Scott   DRUGS

Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients

(2020) Shengjuan Hu et al.   Gastroenterologia y Hepatologia

The hypocretin (orexin) system: from a neural circuitry perspective

(2020) Shi-Bin Li et al.   NEUROPHARMACOLOGY

Editorial: Hypocretins/Orexins

(2020) Miguel López et al.   Frontiers in Endocrinology

Evolution of Orexin Neuropeptide System: Structure and Function

(2020) Shingo Soya et al.   Frontiers in Neuroscience

Sleep disorders and cancer: State of the art and future perspectives

(2020) Maria Paola Mogavero et al.   SLEEP MEDICINE REVIEWS

Orexin-A Stimulates Insulin Secretion Through the Activation of the OX1 Receptor and Mammalian Target of Rapamycin in Rat Insulinoma Cells

(2019) Xiaocen Chang et al.   PANCREAS

Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases

(2019) Alain Couvineau et al.   Frontiers in Endocrinology

TAK-925, an orexin 2 receptor-selective agonist, shows robust wake-promoting effects in mice

(2019) Hiroshi Yukitake et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Orexins/Hypocretins: Key Regulators of Energy Homeostasis

(2019) Edward Milbank et al.   Frontiers in Endocrinology

A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors

(2018) Mark D. Ericson et al.   ACS Chemical Neuroscience

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer

(2018) Jeremy C. Borniger et al.   Cell Metabolism

Effect of orexin-A in the arcuate nucleus on cisplatin-induced gastric side effects in rats

(2018) Feifei Guo et al.   NEUROSCIENCE RESEARCH

In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

(2018) Stéphanie Dayot et al.   Oncotarget

The neuropeptide genes SST, TAC1, HCRT, NPY, and GAL are powerful epigenetic biomarkers in head and neck cancer: a site-specific analysis

(2018) Kiyoshi Misawa et al.   Clinical Epigenetics

When orexins meet cannabinoids: Bidirectional functional interactions

(2018) Fernando Berrendero et al.   BIOCHEMICAL PHARMACOLOGY

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

(2018) N. Messal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Orexin/hypocretin and dysregulated eating: Promotion of foraging behavior

(2018) Jessica R. Barson   BRAIN RESEARCH

The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role

(2018) Alain Couvineau et al.   Frontiers in Endocrinology

To eat or to sleep: That is a lateral hypothalamic question

(2018) Elda Arrigoni et al.   NEUROPHARMACOLOGY

The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells

(2018) Linna Suo et al.   Frontiers in Endocrinology

Molecular Aspects of Circadian Pharmacology and Relevance for Cancer Chronotherapy

(2017) Narin Ozturk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Orexin-A Protects Human Neuroblastoma SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Neurotoxicity: Involvement of PKC and PI3K Signaling Pathways

(2017) Hamzeh Pasban-Aliabadi et al.   REJUVENATION RESEARCH

Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism

(2017) Xing Wan et al.   PLoS One

Lack of expression of preproorexin and orexin receptors genes in human normal and prostate cancer cell lines

(2016) Marta Szyszka et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Effects of orexin A on glucose metabolism in human hepatocellular carcinoma in vitro via PI3K/Akt/mTOR-dependent and -independent mechanism

(2016) Yuanyuan Liu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling

(2016) David E. Kram et al.   PLoS One

Expression and potential role of the peptide orexin-A in prostate cancer

(2015) Salvatore Valiante et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crucial role of the orexin-B C-terminus in the induction of OX1receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis

(2015) Pascal Nicole et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway

(2015) JING WEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

(2015) Takashi Nagahara et al.   JOURNAL OF MEDICINAL CHEMISTRY

The prognostic role of inflammation and hormones in patients with metastatic cancer with cachexia

(2015) Cemil Bilir et al.   MEDICAL ONCOLOGY

Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway

(2015) JING WEN et al.   Molecular Medicine Reports

Function and Dysfunction of Hypocretin/Orexin: An Energetics Point of View

(2014) Xiao-Bing Gao et al.   Annual Review of Neuroscience

A day and night difference in the response of the hepatic transcriptome to cyclophosphamide treatment

(2014) Kirsten C. G. Van Dycke et al.   ARCHIVES OF TOXICOLOGY

Fragmented Sleep Accelerates Tumor Growth and Progression through Recruitment of Tumor-Associated Macrophages and TLR4 Signaling

(2014) F. Hakim et al.   CANCER RESEARCH

The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis

(2014) David Alexandre et al.   EUROPEAN JOURNAL OF CANCER

Orexin-A stimulates 3β-hydroxysteroid dehydrogenase expression and cortisol production in H295R human adrenocortical cells through the AKT pathway

(2014) XIAOCEN CHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway

(2014) YUANYUAN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The role of orexin in motivated behaviours

(2014) Takeshi Sakurai   NATURE REVIEWS NEUROSCIENCE

Neuroprotection by Orexin-A via HIF-1α induction in a cellular model of Parkinson's disease

(2014) Ya Feng et al.   NEUROSCIENCE LETTERS

Orexin/hypocretin receptor signalling: a functional perspective

(2013) C S Leonard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin/hypocretin receptor signalling cascades

(2013) J P Kukkonen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

(2013) Tian-Rui Xu et al.   CELLULAR SIGNALLING

Expression of orexin A and its receptor 1 in the human prostate

(2013) Salvatore Valiante et al.   JOURNAL OF ANATOMY

Expression of Type 2 Orexin Receptor in Human Endometrium and Its Epigenetic Silencing in Endometrial Cancer

(2013) P. Dehan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Protective effect of orexin-A on 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells

(2013) Saeed Esmaeili-Mahani et al.   NEUROCHEMISTRY INTERNATIONAL

Association between Obstructive Sleep Apnea and Cancer Incidence in a Large Multicenter Spanish Cohort

(2012) Francisco Campos-Rodriguez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1and OX2Receptors Identify Slow Kinetics of Agonist Activation

(2012) Tian-Rui Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orexin A Suppresses the Growth of Rat C6 Glioma Cells via a Caspase-Dependent Mechanism

(2012) Kaja Biegańska et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The orexin receptor OX1 R in colon cancer: a promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs

(2011) Marc Laburthe et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis

(2011) T. Voisin et al.   CANCER RESEARCH

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

Orexins and their receptors from fish to mammals: A comparative approach

(2011) Kari K.Y. Wong et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Inflammation and Behavioral Symptoms After Breast Cancer Treatment: Do Fatigue, Depression, and Sleep Disturbance Share a Common Underlying Mechanism?

(2011) Julienne E. Bower et al.   JOURNAL OF CLINICAL ONCOLOGY

Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy

(2011) MASATO KISHIDA et al.   Oncology Letters

Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway

(2010) Lauri M. Louhivuori et al.   CELL CALCIUM

Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons

(2010) M. Kalogiannis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Elevated expression of orexin receptor 2 (HCRTR2) in benign prostatic hyperplasia is accompanied by lowered serum orexin A concentrations

(2010) Malendowicz   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of an orexin receptor positive potentiator

(2010) Jiyong Lee et al.   Chemical Science

Orexins and the regulation of the hypothalamic-pituitary-testicular axis

(2009) M. Nurmio et al.   Acta Physiologica

Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases

(2009) O. Selbach et al.   Acta Physiologica

Activation of the basal forebrain by the orexin/hypocretin neurones

(2009) E. Arrigoni et al.   Acta Physiologica

Orexins/hypocretins and orexin receptors in apoptosis: a mini-review

(2009) M. Laburthe et al.   Acta Physiologica

Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells

(2009) Jan Wenzel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

G protein-coupled receptor hetero-dimerization: contribution to pharmacology and function

(2009) Graeme Milligan   BRITISH JOURNAL OF PHARMACOLOGY

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis

(2009) Aadil El Firar et al.   FASEB JOURNAL

Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

(2009) C. Acuna-Goycolea et al.   JOURNAL OF NEUROSCIENCE

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms

(2008) Thomas M. Bridges et al.   ACS Chemical Biology

The signalling profile of recombinant human orexin-2 receptor

(2008) Jiyou Tang et al.   CELLULAR SIGNALLING

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

(2008) S. L. Borgland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism

(2008) Thierry Voisin et al.   FASEB JOURNAL

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY