Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1and OX2Receptors Identify Slow Kinetics of Agonist Activation

Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

(2012) Paul J. Coleman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

The orexin OX1receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands

(2011) Tian-Rui Xu et al.   BIOCHEMICAL JOURNAL

Real-time visualization of heterotrimeric G protein Gq activation in living cells

(2011) Merel JW Adjobo-Hermans et al.   BMC BIOLOGY

Heteromultimerization of Cannabinoid CB1Receptor and Orexin OX1Receptor Generates a Unique Complex in Which Both Protomers Are Regulated by Orexin A

(2011) Richard J. Ward et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Conformational Dynamics of Single G Protein-Coupled Receptors in Solution

(2011) Samuel Bockenhauer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Developing Chemical Genetic Approaches to Explore G Protein-Coupled Receptor Function: Validation of the Use of a Receptor Activated Solely by Synthetic Ligand (RASSL)

(2011) E. Alvarez-Curto et al.   MOLECULAR PHARMACOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

(2011) Takeshi Sakurai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Applications of fluorescence and bioluminescence resonance energy transfer to drug discovery at G protein coupled receptors

(2010) Elisa Alvarez-Curto et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors

(2010) Nicole Ziegler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand-induced internalization of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging

(2010) Richard J Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypocretin Ligand Deficiency in Narcolepsy: Recent Basic and Clinical Insights

(2010) Cayde Ritchie et al.   Current Neurology and Neuroscience Reports

Orexins/Hypocretins: Pain Regulation and Cellular Actions

(2010) Lih-Chu Chiou et al.   CURRENT PHARMACEUTICAL DESIGN

A Fluorescence Resonance Energy Transfer-based M2Muscarinic Receptor Sensor Reveals Rapid Kinetics of Allosteric Modulation

(2010) Monika Maier-Peuschel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors

(2010) S.-C. Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chemistry and biology of orexin signaling

(2010) Thomas Kodadek et al.   Molecular BioSystems

Mapping the Binding Pocket of Dual Antagonist Almorexant to Human Orexin 1 and Orexin 2 Receptors: Comparison with the Selective OX1 Antagonist SB-674042 and the Selective OX2 Antagonist N-Ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide (EMPA)

(2010) P. Malherbe et al.   MOLECULAR PHARMACOLOGY

Sensing G protein-coupled receptor activation

(2010) Manuela Ambrosio et al.   NEUROPHARMACOLOGY

Signaling by internalized G-protein-coupled receptors

(2010) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Orexins/hypocretins and orexin receptors in apoptosis: a mini-review

(2009) M. Laburthe et al.   Acta Physiologica

G protein-coupled receptors: the inside story

(2009) Kees Jalink et al.   BIOESSAYS

Kinetics of G-protein-coupled receptor signals in intact cells

(2008) M J Lohse et al.   BRITISH JOURNAL OF PHARMACOLOGY

The signalling profile of recombinant human orexin-2 receptor

(2008) Jiyou Tang et al.   CELLULAR SIGNALLING

Orexin Receptor Antagonists: Medicinal Chemistry and Therapeutic Potential

(2008) Anthony Roecker et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors

(2008) Martin J. Lohse et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization

(2007) Jorge Gandía et al.   BIOESSAYS