Daridorexant, a New Dual Orexin Receptor Antagonist to Treat Insomnia Disorder

Accelerated Development of the Dual Orexin Receptor Antagonist ACT-541468: Integration of a Microtracer in a First-in-Human Study

(2018) Clemens Muehlan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline

(2017) Michael J. Sateia et al.   Journal of Clinical Sleep Medicine

The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

(2017) Alexander Treiber et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

European guideline for the diagnosis and treatment of insomnia

(2017) Dieter Riemann et al.   JOURNAL OF SLEEP RESEARCH

Suvorexant for the treatment of primary insomnia: A systematic review and meta-analysis

(2017) Akira Kuriyama et al.   SLEEP MEDICINE REVIEWS

Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians

(2016) Amir Qaseem et al.   ANNALS OF INTERNAL MEDICINE

Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials

(2016) W. Joseph Herring et al.   BIOLOGICAL PSYCHIATRY

Insomnia disorder

(2015) Charles M. Morin et al.   Nature Reviews Disease Primers

Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

(2014) L. Citrome   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder

(2013) Alexandros N. Vgontzas et al.   SLEEP MEDICINE REVIEWS

Model-based dose finding under model uncertainty using general parametric models

(2013) José Pinheiro et al.   STATISTICS IN MEDICINE

Rules for Scoring Respiratory Events in Sleep: Update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events

(2012) Richard B. Berry et al.   Journal of Clinical Sleep Medicine

The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults

(2011) Kelly Posner et al.   AMERICAN JOURNAL OF PSYCHIATRY

Insomnia in central neurologic diseases – Occurrence and management

(2011) Geert Mayer et al.   SLEEP MEDICINE REVIEWS