Analysis of transcriptomic features reveals molecular endotypes of SLE with clinical implications

POS0291 IDENTIFICATION OF SUBSETS OF SLE PATIENTS RESPONSIVE TO IBERDOMIDE BY TRANSCRIPTOMIC ANALYSIS OF BASELINE SAMPLES

(2023) P. Bachali et al.   ANNALS OF THE RHEUMATIC DISEASES

Interpretable machine learning identifies paediatric Systemic Lupus Erythematosus subtypes based on gene expression data

(2022) Sara A. Yones et al.   Scientific Reports

Machine learning reveals distinct gene signature profiles in lesional and nonlesional regions of inflammatory skin diseases

(2022) Brittany A. Martínez et al.   Science Advances

Conceptual framework for defining disease modification in systemic lupus erythematosus: a call for formal criteria

(2022) Ronald van Vollenhoven et al.   Lupus Science & Medicine

Identification and stratification of systemic lupus erythematosus patients into two transcriptionally distinct clusters based on IFN-I signature

(2021) Vineeta Shobha et al.   LUPUS

Sub-Setting Systemic Lupus Erythematosus by Combined Molecular Phenotypes Defines Divergent Populations in Two Phase III Randomized Trials

(2021) Michelle Petri et al.   RHEUMATOLOGY

Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway

(2021) Andrea R. Daamen et al.   Scientific Reports

Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene Expression

(2021) Nathaniel Stearrett et al.   Frontiers in Immunology

Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

(2021) Gaia Andreoletti et al.   Communications Biology

Transcription Factor Activity Inference in Systemic Lupus Erythematosus

(2021) Raul Lopez-Dominguez et al.   Life-Basel

Transcriptomics data

(2021) Erika L. Hubbard et al.   CURRENT OPINION IN RHEUMATOLOGY

Altered expression of genes controlling metabolism characterizes the tissue response to immune injury in lupus

(2021) Kathryn M. Kingsmore et al.   Scientific Reports

Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes

(2021) Alessandra Petrelli et al.   Current Diabetes Reports

In search of pathobiological endotypes: a systems approach to early rheumatoid arthritis

(2020) Jessica R. Tarn et al.   Expert Review of Clinical Immunology

Mapping systemic lupus erythematosus heterogeneity at the single-cell level

(2020) Djamel Nehar-Belaid et al.   NATURE IMMUNOLOGY

Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus

(2020) Michelle D. Catalina et al.   JCI Insight

Update οn the diagnosis and management of systemic lupus erythematosus

(2020) Antonis Fanouriakis et al.   ANNALS OF THE RHEUMATIC DISEASES

Analysis of gene expression from systemic lupus erythematosus synovium reveals myeloid cell-driven pathogenesis of lupus arthritis

(2020) Erika L. Hubbard et al.   Scientific Reports

Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

(2019) Ioana Agache et al.   JOURNAL OF CLINICAL INVESTIGATION

Machine learning approaches to predict lupus disease activity from gene expression data

(2019) Brian Kegerreis et al.   Scientific Reports

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

IFN-α kinoid in systemic lupus erythematosus: results from a phase IIb, randomised, placebo-controlled study

(2019) Frederic A Houssiau et al.   ANNALS OF THE RHEUMATIC DISEASES

Identification of a gene-expression predictor for diagnosis and personalized stratification of lupus patients

(2018) Yan Ding et al.   PLoS One

Longitudinal Stratification of Gene Expression Reveals Three SLE Groups of Disease Activity Progression

(2018) Daniel Toro-Domínguez et al.   Arthritis & Rheumatology

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

(2018) Yanhua Hu et al.   Arthritis & Rheumatology

Gene Expression and Pharmacodynamic Changes in 1,760 Systemic Lupus Erythematosus Patients From Two Phase III Trials of BAFF Blockade With Tabalumab

(2017) Robert W. Hoffman et al.   Arthritis & Rheumatology

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

(2016) Julie Ducreux et al.   RHEUMATOLOGY

The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus

(2016) Myles J. Lewis et al.   RHEUMATOLOGY

Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study

(2015) J T Merrill et al.   ANNALS OF THE RHEUMATIC DISEASES

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

(2015) T. Hung et al.   SCIENCE

Lymphotoxin-LIGHT Pathway Regulates the Interferon Signature in Rheumatoid Arthritis

(2014) Jadwiga Bienkowska et al.   PLoS One

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid

(2012) Bernard R. Lauwerys et al.   ARTHRITIS AND RHEUMATISM

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE