Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy

(2019) Seunghee Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

Epigenetic programming underpins B cell dysfunction in human SLE

(2019) Christopher D. Scharer et al.   NATURE IMMUNOLOGY

BBKNN: fast batch alignment of single cell transcriptomes

(2019) Krzysztof Polański et al.   BIOINFORMATICS

Monogenic lupus: Dissecting heterogeneity

(2019) Ommar Omarjee et al.   AUTOIMMUNITY REVIEWS

Fast, sensitive and accurate integration of single-cell data with Harmony

(2019) Ilya Korsunsky et al.   NATURE METHODS

Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations

(2019) Ignacio Sanz et al.   Frontiers in Immunology

Tissue-Resident Memory T Cells Mediate Immune Homeostasis in the Human Pancreas through the PD-1/PD-L1 Pathway

(2019) Stuart P. Weisberg et al.   Cell Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

New therapeutic strategies in systemic lupus erythematosus management

(2018) Mariele Gatto et al.   Nature Reviews Rheumatology

Multiplexed quantification of proteins and transcripts in single cells

(2017) Vanessa M Peterson et al.   NATURE BIOTECHNOLOGY

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Transancestral mapping and genetic load in systemic lupus erythematosus

(2017) Carl D. Langefeld et al.   Nature Communications

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Assessment of Type I Interferon Signaling in Pediatric Inflammatory Disease

(2016) Gillian I. Rice et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

(2015) Jellert T. Gaublomme et al.   CELL

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus

(2015) Christopher M Tipton et al.   NATURE IMMUNOLOGY

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow

(2015) Andreas Schlitzer et al.   NATURE IMMUNOLOGY

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN Priming Is Necessary but Not Sufficient To Turn on a Migratory Dendritic Cell Program in Lupus Monocytes

(2014) A. Rodriguez-Pla et al.   JOURNAL OF IMMUNOLOGY

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

SLE Peripheral Blood B Cell, T Cell and Myeloid Cell Transcriptomes Display Unique Profiles and Each Subset Contributes to the Interferon Signature

(2013) Amy M. Becker et al.   PLoS One

Type I IFN system in the development and manifestations of SLE

(2012) Keith B. Elkon et al.   CURRENT OPINION IN RHEUMATOLOGY

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

Host Immune Transcriptional Profiles Reflect the Variability in Clinical Disease Manifestations in Patients with Staphylococcus aureus Infections

(2012) Romain Banchereau et al.   PLoS One

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Mycophenolic Acid Differentially Impacts B Cell Function Depending on the Stage of Differentiation

(2011) J. L. Karnell et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

CD2 Distinguishes Two Subsets of Human Plasmacytoid Dendritic Cells with Distinct Phenotype and Functions

(2009) T. Matsui et al.   JOURNAL OF IMMUNOLOGY

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: Delineation by expression of CD27, IgD, and CD95

(2008) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY