Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes

Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells

(2021) Iacopo Gesmundo et al.   JCI Insight

Early impairment of insulin sensitivity, β-cell responsiveness, and insulin clearance in youth with Stage 1 type 1 diabetes

(2021) Alfonso Galderisi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High‐fat diet prevents the development of autoimmune diabetes in NOD mice

(2021) Amy L. Clark et al.   DIABETES OBESITY & METABOLISM

Identification and Characterization of Adipose Tissue-Derived Human Antibodies With “Anti-self” Specificity

(2020) Daniela Frasca et al.   Frontiers in Immunology

Enrichment of Tc1 cells and T cell resistance to suppression are associated with dysglycemia in the visceral fat in human obesity

(2020) Sara Cardellini et al.   BMJ Open Diabetes Research & Care

Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2020) Wendy K. Chung et al.   DIABETES CARE

Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in Patients With Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

(2020) Marieke de Vries et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

(2020) Torsten P. M. Scheithauer et al.   Frontiers in Immunology

Golimumab and Beta-Cell Function in Youth with New-Onset Type 1 Diabetes

(2020) Teresa Quattrin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular immunological changes in patients with LADA are a mixture of those seen in patients with type 1 and type 2 diabetes

(2019) K. Singh et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Metformin Improves Peripheral Insulin Sensitivity in Youth with Type 1 Diabetes

(2019) Melanie Cree-Green et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes

(2019) Chiara Sorini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Setting the Stage for Islet Autoimmunity in Type 2 Diabetes: Obesity-Associated Chronic Systemic Inflammation and Endoplasmic Reticulum (ER) Stress

(2019) Barbara M. Brooks-Worrell et al.   DIABETES CARE

Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance

(2018) Eddie A. James et al.   DIABETES

Effect of a glucagon receptor antibody (REMD-477) in type 1 diabetes: A randomized controlled trial

(2018) Jeremy Pettus et al.   DIABETES OBESITY & METABOLISM

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

(2018) Emma Ahlqvist et al.   Lancet Diabetes & Endocrinology

Conventional and Neo-Antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

(2018) Sergio Gonzalez-Duque et al.   Cell Metabolism

The role of IFN in the development of NAFLD and NASH

(2018) Michelle Møhlenberg et al.   CYTOKINE

High CD8 T Cell Receptor Clonality and Altered CDR3 Properties are Associated with Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity

(2018) Wyatt J. McDonnell et al.   DIABETES

Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs

(2018) Justin M. Gregory et al.   DIABETES OBESITY & METABOLISM

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug

(2017) Hao Wu et al.   NATURE MEDICINE

Adult-onset autoimmune diabetes: current knowledge and implications for management

(2017) Raffaella Buzzetti et al.   Nature Reviews Endocrinology

T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

(2017) Iria Gomez-Tourino et al.   Nature Communications

Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

(2017) Nicole M. Templeman et al.   Cell Reports

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

(2017) John R Petrie et al.   Lancet Diabetes & Endocrinology

A Review of Insulin Resistance in Type 1 Diabetes: Is There a Place for Adjunctive Metformin?

(2017) Gagan Priya et al.   Diabetes Therapy

A Review of Insulin Resistance in Type 1 Diabetes: Is There a Place for Adjunctive Metformin?

(2017) Gagan Priya et al.   Diabetes Therapy

T-cell receptor repertoire variation may be associated with type 2 diabetes mellitus in humans

(2016) Joseph A. Frankl et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positivity and type 1 diabetes among TrialNet Pathway to Prevention participants

(2016) Farah A. Meah et al.   DIABETOLOGIA

Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes

(2016) Jason Flannick et al.   Nature Reviews Endocrinology

Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes

(2015) Justin M. Gregory et al.   DIABETES

Large adipocytes function as antigen-presenting cells to activate CD4+ T cells via upregulating MHCII in obesity

(2015) L Xiao et al.   INTERNATIONAL JOURNAL OF OBESITY

Abatacept Improves Whole-Body Insulin Sensitivity in Rheumatoid Arthritis

(2015) Francesco Ursini et al.   MEDICINE

Insulin resistance in type 1 diabetes mellitus

(2015) Kirti Kaul et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Immunogenetics of type 1 diabetes mellitus

(2015) Michael P. Morran et al.   MOLECULAR ASPECTS OF MEDICINE

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

(2015) Rashmi Prasad et al.   Genes

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes

(2014) Teresa Rodriguez-Calvo et al.   DIABETES

Impact of Islet Autoimmunity on the Progressive β-Cell Functional Decline in Type 2 Diabetes

(2014) Barbara M. Brooks-Worrell et al.   DIABETES CARE

CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes

(2014) Ghanashyam Sarikonda et al.   JOURNAL OF AUTOIMMUNITY

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation

(2013) Tuo Deng et al.   Cell Metabolism

Role of Adipokines Signaling in the Modulation of T Cells Function

(2013) Claudio Procaccini et al.   Frontiers in Immunology

CXCR1/2 inhibition enhances pancreatic islet survival after transplantation

(2012) Antonio Citro et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

T-Lymphocyte Responses to Intestinally Absorbed Antigens Can Contribute to Adipose Tissue Inflammation and Glucose Intolerance during High Fat Feeding

(2010) Yuehui Wang et al.   PLoS One

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

(2009) Naim Alkhouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE