Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms

(2022) Xu Chen et al.   Cell Metabolism

Complex processes underlying the dynamic changes of D-serine level in AD brains

(2022) Xiance Nia et al.   Current Alzheimer Research

Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus

(2022) Elisa Maffioli et al.   Cell Reports

The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer’s disease

(2022) Oluwarotimi O. Folorunso et al.   NEUROSCIENCE LETTERS

The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease

(2021) Rayhanatou Altiné‐Samey et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Serum d-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker

(2021) Luciano Piubelli et al.   Translational Psychiatry

Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain Samples by LC/MS/MS Combined with Derivatization Using Nα-(5-Fluoro-2,4-dinitrophenyl)-l-leucinamide (l-FDLA)

(2021) Taiji Yamamoto et al.   Metabolites

Female specific risk factors for the development of Alzheimer’s disease neuropathology and cognitive impairment: Call for a precision medicine approach

(2021) Chinedu Udeh-Momoh et al.   AGEING RESEARCH REVIEWS

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

(2021) Emrin Horgusluoglu et al.   Alzheimers & Dementia

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

(2020) Juliette Le Douce et al.   Cell Metabolism

Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study

(2020) Uma V. Mahajan et al.   PLOS MEDICINE

Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer’s Disease

(2020) Zhangming Yan et al.   CURRENT BIOLOGY

L-Serine links metabolism with neurotransmission

(2020) Marianne Maugard et al.   PROGRESS IN NEUROBIOLOGY

Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease

(2020) Tommaso Nuzzo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases

(2020) Gloria Biechele et al.   Journal of Neuroinflammation

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Astroglial atrophy in Alzheimer’s disease

(2019) Alexei Verkhratsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

(2019) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

(2018) Juho Tynkkynen et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-G-F/NL-G-F) model of Alzheimer's disease

(2018) Jogender Mehla et al.   NEUROBIOLOGY OF AGING

Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury

(2017) Enmanuel J. Perez et al.   JOURNAL OF CLINICAL INVESTIGATION

Points of Significance: Principal component analysis

(2017) Jake Lever et al.   NATURE METHODS

Amino Acid Catabolism in Alzheimer’s Disease Brain: Friend or Foe?

(2017) Jeddidiah W. D. Griffin et al.   Oxidative Medicine and Cellular Longevity

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls

(2016) Elisanne A.L.M. Biemans et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

(2016) Xiaobei Pan et al.   NEUROBIOLOGY OF AGING

Cognitive deficits in single App knock-in mouse models

(2016) Akira Masuda et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Cytokine regulation by modulation of the NMDA receptor on astrocytes

(2016) Kurt-Wolfram Sühs et al.   NEUROSCIENCE LETTERS

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

d-Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain

(2014) Darrick T. Balu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Localization of Serine Racemase and Its Role in the Skin

(2014) Ran Inoue et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

(2014) Pradip K. Kamat et al.   MOLECULAR NEUROBIOLOGY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Increased Sensitivity to Inflammatory Pain Induced by Subcutaneous Formalin Injection in Serine Racemase Knock-Out Mice

(2014) Ayako Tabata-Imai et al.   PLoS One

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

D-serine increases adult hippocampal neurogenesis

(2013) Sebastien Sultan et al.   Frontiers in Neuroscience

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

(2012) Willem Kamphuis et al.   PLoS One

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

Effect of Three Types of Mixed Anesthetic Agents Alternate to Ketamine in Mice

(2011) Sumiko KAWAI et al.   EXPERIMENTAL ANIMALS

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Glycine Site of NMDA Receptor Serves as a Spatiotemporal Detector of Synaptic Activity Patterns

(2009) Yan Li et al.   JOURNAL OF NEUROPHYSIOLOGY

NMDA- and  -Amyloid1-42-Induced Neurotoxicity Is Attenuated in Serine Racemase Knock-Out Mice

(2009) R. Inoue et al.   JOURNAL OF NEUROSCIENCE

What does the retrosplenial cortex do?

(2009) Seralynne D. Vann et al.   NATURE REVIEWS NEUROSCIENCE

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

(2009) Hung-Ming Wu et al.   NEUROPSYCHOPHARMACOLOGY

Serine racemase is predominantly localized in neurons in mouse brain

(2008) Kazushi Miya et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY