Prognostic impact of PTK6 expression in triple negative breast cancer

Epigenetic Deregulation of Protein Tyrosine Kinase 6 Promotes Carcinogenesis of Oral Squamous Cell Carcinoma

(2022) Yi-Ping Hsieh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Comprehensive Analysis Reveals PTK6 as a Prognostic Biomarker Involved in the Immunosuppressive Microenvironment in Breast Cancer

(2022) Lili Wang et al.   Journal of Immunology Research

HER2-Low Breast Cancer: Pathological and Clinical Landscape

(2020) Paolo Tarantino et al.   JOURNAL OF CLINICAL ONCOLOGY

Strategic Developments & Future Perspective on Gene therapy of Breast Cancer: Role of mTOR and Brk/ PTK6 as Molecular Targets

(2020) Roja Sahu et al.   CURRENT GENE THERAPY

Triple-negative breast cancer: promising prognostic biomarkers currently in development

(2020) Jasmine Sukumar et al.   Expert Review of Anticancer Therapy

Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

(2019) Sayem Miah et al.   BMC CANCER

Hormone receptor and human epidermal growth factor receptor 2 detection in invasive breast carcinoma: A retrospective study in 12467 patients from 19 Chinese representative clinical centers

(2019) Ruohong Shui et al.   Clinical Breast Cancer

BRK phosphorylates SMAD4 for proteasomal degradation and inhibits tumor suppressor FRK to control SNAIL, SLUG, and metastatic potential

(2019) S. Miah et al.   Science Advances

Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

(2018) Tarah M. Regan Anderson et al.   MOLECULAR CANCER RESEARCH

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

(2018) Luping Qiu et al.   PLoS One

PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8

(2017) Won-Sik Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Overexpression of PTK6 predicts poor prognosis in bladder cancer patients

(2017) Xue-lian Xu et al.   Journal of Cancer

PTK6 Inhibition Suppresses Metastases of Triple-Negative Breast Cancer via SNAIL-Dependent E-Cadherin Regulation

(2016) K. Ito et al.   CANCER RESEARCH

Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors

(2016) Jie Jiang et al.   CANCER RESEARCH

Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer

(2016) Tarah M. Regan Anderson et al.   CANCER RESEARCH

Moderate HER2 expression as a prognostic factor in hormone receptor positive breast cancer

(2015) Holm Eggemann et al.   ENDOCRINE-RELATED CANCER

Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse

(2015) M Peng et al.   Cell Death & Disease

Discovery of 4-anilino α-carbolines as novel Brk inhibitors

(2014) Kazem Ahmed Mahmoud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of ( E )-5-(benzylideneamino)-1 H -benzo[ d ]imidazol-2(3 H )-one derivatives as inhibitors for PTK6

(2014) Hyun Jae Shim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

(2014) Isabel M Pires et al.   CANCER BIOLOGY & THERAPY

Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma

(2014) You-Fang Chen et al.   MEDICAL ONCOLOGY

Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

(2013) T. M. Regan Anderson et al.   CANCER RESEARCH

Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer

(2013) Yu Zheng et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors

(2013) Ahmed I. Foudah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma

(2013) Xue-Kui Liu et al.   Journal of Translational Medicine

Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis

(2013) Li-na Liu et al.   Journal of Translational Medicine

Effects of Simultaneous Knockdown of HER2 and PTK6 on Malignancy and Tumor Progression in Human Breast Cancer Cells

(2013) Natalie Ludyga et al.   MOLECULAR CANCER RESEARCH

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

(2012) Shin-Ae Kang et al.   BIOCHEMICAL JOURNAL

Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells following DNA Damage

(2012) J. J. Gierut et al.   MOLECULAR CANCER THERAPEUTICS

Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance

(2011) Chuifeng Fan et al.   TUMOR BIOLOGY

Involvement of STAP-2 in Brk-mediated phosphorylation and activation of STAT5 in breast cancer cells

(2010) Osamu Ikeda et al.   CANCER SCIENCE

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

(2010) Hanna Y. Irie et al.   PLoS One

Breast Tumor Kinase Phosphorylates p190RhoGAP to Regulate Rho and Ras and Promote Breast Carcinoma Growth, Migration, and Invasion

(2008) C.-H. Shen et al.   CANCER RESEARCH

Brk is coamplified with ErbB2 to promote proliferation in breast cancer

(2008) B. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA