Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer

Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers

(2012) Nancy L. Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

(2012) Shin-Ae Kang et al.   BIOCHEMICAL JOURNAL

Identification of PTK6, via RNA Sequencing Analysis, as a Suppressor of Esophageal Squamous Cell Carcinoma

(2012) Stephanie Ma et al.   GASTROENTEROLOGY

Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

(2012) Yiwei Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells following DNA Damage

(2012) J. J. Gierut et al.   MOLECULAR CANCER THERAPEUTICS

Wnt/β-catenin signalling in prostate cancer

(2012) Robert M. Kypta et al.   Nature Reviews Urology

Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR

(2012) X Li et al.   ONCOGENE

A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations

(2012) Tao Xie et al.   PLoS One

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors

(2011) Hongbo Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The RNA-binding protein Sam68 is a multifunctional player in human cancer

(2011) P. Bielli et al.   ENDOCRINE-RELATED CANCER

Disruption of the Mouse Protein Tyrosine Kinase 6 Gene Prevents STAT3 Activation and Confers Resistance to Azoxymethane

(2011) Jessica Gierut et al.   GASTROENTEROLOGY

Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate

(2011) Yu Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer

(2011) Natalie Ludyga et al.   Molecular BioSystems

The Alternative Splice Variant of Protein Tyrosine Kinase 6 Negatively Regulates Growth and Enhances PTK6-Mediated Inhibition of β-Catenin

(2011) Patrick M. Brauer et al.   PLoS One

Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance

(2011) Chuifeng Fan et al.   TUMOR BIOLOGY

Mechanisms of HGF/Met Signaling to Brk and Sam68 in Breast Cancer Progression

(2011) Alessia Locatelli et al.   Hormones & Cancer

Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells

(2010) Patrick M. Brauer et al.   CELL CYCLE

Brk/PTK6 signaling in normal and cancer cell models

(2010) Julie H Ostrander et al.   CURRENT OPINION IN PHARMACOLOGY

Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer

(2010) Joanne Edwards   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Interactions of STAP-2 with Brk and STAT3 Participate in Cell Growth of Human Breast Cancer Cells

(2010) Osamu Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor

(2010) Y. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

(2010) Hanna Y. Irie et al.   PLoS One

STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation

(2009) Osamu Ikeda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of Protein Tyrosine Kinase 6 in Mouse Intestinal Crypt Epithelial Cells Promotes DNA Damage–Induced Apoptosis

(2009) Andrea Haegebarth et al.   GASTROENTEROLOGY

Oncogenic Functions of PTK6 are Enhanced by Its Targeting to Plasma Membrane But Abolished by Its Targeting to Nucleus

(2009) H. Ie Kim et al.   JOURNAL OF BIOCHEMISTRY

Identification of  -catenin as a target of the intracellular tyrosine kinase PTK6

(2009) H. L. Palka-Hamblin et al.   JOURNAL OF CELL SCIENCE

Src as a therapeutic target in men with prostate cancer and bone metastases

(2008) Fred Saad   BJU INTERNATIONAL

Breast Tumor Kinase Phosphorylates p190RhoGAP to Regulate Rho and Ras and Promote Breast Carcinoma Growth, Migration, and Invasion

(2008) C.-H. Shen et al.   CANCER RESEARCH

BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells

(2008) E. Sala et al.   MOLECULAR CANCER RESEARCH