Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution

(2016) Manish Kumar Thakur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTK6 Inhibition Suppresses Metastases of Triple-Negative Breast Cancer via SNAIL-Dependent E-Cadherin Regulation

(2016) K. Ito et al.   CANCER RESEARCH

Targeting BRK-Positive Breast Cancers with Small-Molecule Kinase Inhibitors

(2016) Jie Jiang et al.   CANCER RESEARCH

Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer

(2016) P. S. Mathur et al.   MOLECULAR CANCER RESEARCH

Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition

(2015) Tiffany Tsui et al.   BIOCHEMISTRY

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors

(2015) Maoyu Peng et al.   Oncotarget

Discovery of 4-anilino α-carbolines as novel Brk inhibitors

(2014) Kazem Ahmed Mahmoud et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of ( E )-5-(benzylideneamino)-1 H -benzo[ d ]imidazol-2(3 H )-one derivatives as inhibitors for PTK6

(2014) Hyun Jae Shim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PTK6 Promotes Cancer Migration and Invasion in Pancreatic Cancer Cells Dependent on ERK Signaling

(2014) Hiroaki Ono et al.   PLoS One

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT

(2012) Y Zheng et al.   ONCOGENE

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors

(2011) Hongbo Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain

(2011) Xiao-Fei Zeng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protein-tyrosine Kinase 6 Promotes Peripheral Adhesion Complex Formation and Cell Migration by Phosphorylating p130 CRK-associated Substrate

(2011) Yu Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor

(2010) Y. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

(2010) Hanna Y. Irie et al.   PLoS One

Oncogenic Functions of PTK6 are Enhanced by Its Targeting to Plasma Membrane But Abolished by Its Targeting to Nucleus

(2009) H. Ie Kim et al.   JOURNAL OF BIOCHEMISTRY

Overexpression of PTK6 (breast tumor kinase) protein—a prognostic factor for long-term breast cancer survival—is not due to gene amplification

(2009) Michaela Aubele et al.   VIRCHOWS ARCHIV

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients

(2008) M Aubele et al.   BRITISH JOURNAL OF CANCER