Organelles are miscommunicating: Membrane contact sites getting hijacked by pathogens

Legionella ‐ and host‐driven lipid flux at LCV‐ER membrane contact sites promotes vacuole remodeling

(2023) Simone Vormittag et al.   EMBO REPORTS

Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT

(2022) Kentaro Hanada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles

(2022) Pin-Chao Liao et al.   Frontiers in Cell and Developmental Biology

Restructured membrane contacts rewire organelles for human cytomegalovirus infection

(2022) Katelyn C. Cook et al.   Nature Communications

Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites

(2022) Rachel J Ende et al.   eLife

The role of membrane contact sites at the bacteria-host interface

(2021) Chen Jiang et al.   CRITICAL REVIEWS IN MICROBIOLOGY

A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction

(2020) Valentina Basso et al.   CELL CALCIUM

NOD1/NOD2 and RIP2 Regulate Endoplasmic Reticulum Stress-Induced Inflammation during Chlamydia Infection

(2020) Oanh H. Pham et al.   mBio

Rab7 controls lipid droplet-phagosome association during mycobacterial infection

(2020) Natalia R. Roque et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Extended synaptotagmin regulates membrane contact site structure and lipid transfer function in vivo

(2020) Vaisaly R Nath et al.   EMBO REPORTS

TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology

(2020) Shasha Chen et al.   MOLECULAR CELL

Coming together to define membrane contact sites

(2019) Luca Scorrano et al.   Nature Communications

Bronchial Epithelial Calcium Metabolism Impairment in Smokers and COPD: Decreased ORAI3 Signaling

(2019) Aurelie Petit et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ancient complement and lineage-specific evolution of the Sec7 ARF GEF proteins in eukaryotes

(2019) Shweta V. Pipaliya et al.   MOLECULAR BIOLOGY OF THE CELL

The functional universe of membrane contact sites

(2019) William A. Prinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production

(2018) Jingshu Zhang et al.   Cell Host & Microbe

ER-PM Contacts Restrict Exocytic Sites for Polarized Morphogenesis

(2018) Amanda Yunn Ee Ng et al.   CURRENT BIOLOGY

Impact of Active Metabolism on Chlamydia trachomatis Elementary Body Transcript Profile and Infectivity

(2018) Scott Grieshaber et al.   JOURNAL OF BACTERIOLOGY

Kv2 potassium channels form endoplasmic reticulum/plasma membrane junctions via interaction with VAPA and VAPB

(2018) Ben Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum-plasma membrane contact sites integrate sterol and phospholipid regulation

(2018) Evan Quon et al.   PLOS BIOLOGY

Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis

(2017) Ina Karen Stoeck et al.   JOURNAL OF VIROLOGY

IncV, a FFAT motif-containingChlamydiaprotein, tethers the endoplasmic reticulum to the pathogen-containing vacuole

(2017) Rebecca Stanhope et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Tales of Viral Replication and Transmission

(2017) Nihal Altan-Bonnet   TRENDS IN CELL BIOLOGY

Phosphoinositides in membrane contact sites

(2016) Camilla Raiborg et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

VAP, a Versatile Access Point for the Endoplasmic Reticulum: Review and analysis of FFAT-like motifs in the VAPome

(2016) Sarah E. Murphy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of store-operated calcium entry by sub-lethal levels of proteasome inhibition is associated with STIM1/STIM2 degradation

(2016) Xiu-li Kuang et al.   CELL CALCIUM

Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L

(2016) Anna V. Justis et al.   CELLULAR MICROBIOLOGY

The life stage-specific pathometabolism ofLegionella pneumophila

(2016) Wolfgang Eisenreich et al.   FEBS LETTERS

Building Viral Replication Organelles: Close Encounters of the Membrane Types

(2016) Peter D. Nagy et al.   PLoS Pathogens

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

(2015) Lucian Albulescu et al.   ANTIVIRAL RESEARCH

TheMycobacterium tuberculosisprotein pair PE9 (Rv1088)-PE10 (Rv1089) forms heterodimers and induces macrophage apoptosis through Toll-like receptor 4

(2015) Bhavana Tiwari et al.   CELLULAR MICROBIOLOGY

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

(2015) Li Wen et al.   GASTROENTEROLOGY

Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9

(2015) Eva Haenssler et al.   INFECTION AND IMMUNITY

Mdm1/Snx13 is a novel ER–endolysosomal interorganelle tethering protein

(2015) W. Mike Henne et al.   JOURNAL OF CELL BIOLOGY

STIM1 Is a Novel Component of ER-Chlamydia trachomatis Inclusion Membrane Contact Sites

(2015) Hervé Agaisse et al.   PLoS One

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

(2015) Jeroen R.P.M. Strating et al.   Cell Reports

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

(2015) Alberto T Gatta et al.   eLife

Bacterial Pathogen Manipulation of Host Membrane Trafficking

(2014) Seblewongel Asrat et al.   Annual Review of Cell and Developmental Biology

Chlamydia pneumoniae harness host NLRP3 inflammasome-mediated caspase-1 activation for optimal intracellular growth in murine macrophages

(2014) Ryota Itoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rhinovirus Uses a Phosphatidylinositol 4-Phosphate/Cholesterol Counter-Current for the Formation of Replication Compartments at the ER-Golgi Interface

(2014) Pascal S. Roulin et al.   Cell Host & Microbe

The Machinery at Endoplasmic Reticulum-Plasma Membrane Contact Sites Contributes to Spatial Regulation of Multiple Legionella Effector Proteins

(2014) Andree Hubber et al.   PLoS Pathogens

Phosphatidylinositol-4-phosphate: The Golgi and beyond

(2013) Maria A. De Matteis et al.   BIOESSAYS

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Candida albicans: Adapting to Succeed

(2013) David Kadosh et al.   Cell Host & Microbe

Maintenance of vacuole integrity by bacterial pathogens

(2013) Elizabeth A. Creasey et al.   CURRENT OPINION IN MICROBIOLOGY

Oxysterol-Binding Protein Family I Is the Target of Minor Enviroxime-Like Compounds

(2013) M. Arita et al.   JOURNAL OF VIROLOGY

Structure of a pathogenic type 3 secretion system in action

(2013) Julia Radics et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

(2013) J. R. Barker et al.   mBio

Increased Long Chain acyl-Coa Synthetase Activity and Fatty Acid Import Is Linked to Membrane Synthesis for Development of Picornavirus Replication Organelles

(2013) Jules A. Nchoutmboube et al.   PLoS Pathogens

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

(2012) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis

(2012) Paula Nunes et al.   CURRENT BIOLOGY

The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in Macrophages

(2012) Bhavana Mishra Tiwari et al.   PLoS One

Phosphatidylinositol 4-kinases: hostages harnessed to build panviral replication platforms

(2012) Nihal Altan-Bonnet et al.   TRENDS IN BIOCHEMICAL SCIENCES

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

Manipulation of host vesicular trafficking and innate immune defence by Legionella Dot/Icm effectors

(2011) Jianning Ge et al.   CELLULAR MICROBIOLOGY

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

The Coxiella burnetii Dot/Icm System Delivers a Unique Repertoire of Type IV Effectors into Host Cells and Is Required for Intracellular Replication

(2011) Kimberly L. Carey et al.   PLoS Pathogens

Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

(2011) Cherilyn A. Elwell et al.   PLoS Pathogens

The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites

(2011) Isabelle Derré et al.   PLoS Pathogens

Modulation of Host Cell Function byLegionella pneumophilaType IV Effectors

(2010) Andree Hubber et al.   Annual Review of Cell and Developmental Biology

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Dengue Virus-Induced Autophagy Regulates Lipid Metabolism

(2010) Nicholas S. Heaton et al.   Cell Host & Microbe

Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity

(2010) M. Arita et al.   JOURNAL OF VIROLOGY

Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA

(2010) Y. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments

(2009) Yadunanda Kumar et al.   Cell Host & Microbe

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

(2009) Céline Castanier et al.   EMBO REPORTS

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein ofLegionella pneumophila

(2008) Eva Brombacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens