Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review
Authors
Keywords
-
Journal
Nutrients
Volume 15, Issue 21, Pages 4699
Publisher
MDPI AG
Online
2023-11-06
DOI
10.3390/nu15214699
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Folic Acid, Folinic Acid, 5 Methyl TetraHydroFolate Supplementation for Mutations That Affect Epigenesis through the Folate and One-Carbon Cycles
- (2022) Yves Menezo et al. Biomolecules
- Folate intake and risk of colorectal cancer: a systematic review and up-to-date meta-analysis of prospective studies
- (2022) Hongjuan Fu et al. EUROPEAN JOURNAL OF CANCER PREVENTION
- Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study
- (2022) Shuyuan Chu et al. BMC Pregnancy and Childbirth
- Intakes of Folate, Vitamin B6, and Vitamin B12 in Relation to All-Cause and Cause-Specific Mortality: A National Population-Based Cohort
- (2022) Yacong Bo et al. Nutrients
- Moderate Folic Acid Supplementation in Pregnant Mice Results in Altered Sex-Specific Gene Expression in Brain of Young Mice and Embryos
- (2022) Yan Luan et al. Nutrients
- Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms
- (2022) Miroslava Ondičová et al. Clinical Epigenetics
- Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review
- (2022) Carolyn Ledowsky et al. Nutrients
- Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort
- (2022) Boya Zhang et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Folic acid depletion as well as oversupplementation helps in the progression of hepatocarcinogenesis in HepG2 cells
- (2022) Renuka Sharma et al. Scientific Reports
- The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4–5 Years of Age in the INMA Project
- (2021) Laura María Compañ Gabucio et al. Nutrients
- Effect of Folic Acid Intake on Infant and Child Allergic Diseases: Systematic Review and Meta-Analysis
- (2021) Zekun Chen et al. Frontiers in Pediatrics
- Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial
- (2021) Aoife Caffrey et al. BMC Medicine
- Association of folate intake and colorectal cancer risk in the postfortification era in US women
- (2021) Fenglei Wang et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- High Intakes of [6S]-5-Methyltetrahydrofolic Acid Compared with Folic Acid during Pregnancy Programs Central and Peripheral Mechanisms Favouring Increased Food Intake and Body Weight of Mature Female Offspring
- (2021) Emanuela Pannia et al. Nutrients
- Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease
- (2021) Brock A. Williams et al. Frontiers in Nutrition
- Relationship of several serum folate forms with the risk of mortality: A prospective cohort study
- (2021) Mengyi Liu et al. CLINICAL NUTRITION
- The Concept of Folic Acid in Health and Disease
- (2021) Yulia Shulpekova et al. MOLECULES
- Folate Intake and Risk of Urothelial Carcinoma: A Systematic Review and Meta-Analysis of Epidemiological Studies
- (2021) Yi Gu* et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Regulation of the one carbon folate cycle as a shared metabolic signature of longevity
- (2021) Andrea Annibal et al. Nature Communications
- Effects of Folic Acid Supplementation on Inflammatory Markers: A Grade-Assessed Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials
- (2021) Omid Asbaghi et al. Nutrients
- Excess folic acid supplementation before and during pregnancy and lactation activates β-catenin in the brain of male mouse offspring
- (2021) Qian Wu et al. BRAIN RESEARCH BULLETIN
- Excess Folic Acid Supplementation before and during Pregnancy and Lactation Alters Behaviors and Brain Gene Expression in Female Mouse Offspring
- (2021) Xingyue Yang et al. Nutrients
- The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis
- (2021) Ali M. Fardous et al. Nutrients
- Perspective: The High-Folate–Low-Vitamin B-12 Interaction Is a Novel Cause of Vitamin B-12 Depletion with a Specific Etiology—A Hypothesis
- (2021) Jacob Selhub et al. Advances in Nutrition
- Precise Dose of Folic Acid Supplementation Is Essential for Embryonic Heart Development in Zebrafish
- (2021) Xuhui Han et al. Biology-Basel
- Maternal folic acid and multivitamin supplementation: International clinical evidence with considerations for the prevention of folate-sensitive birth defects
- (2021) R.D. Wilson et al. Preventive Medicine Reports
- Association between one-carbon metabolism-related vitamins and risk of breast cancer: a systematic review and meta-analysis of prospective studies
- (2020) Jie Zeng et al. Clinical Breast Cancer
- Maternal Folic Acid Supplementation Mediates Offspring Health via DNA Methylation
- (2020) Huan-Yu Liu et al. Reproductive Sciences
- Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial
- (2020) Jéssica Vanessa de Carvalho Lisboa et al. Nutrients
- Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers
- (2020) Olga Egorova et al. Molecular Autism
- Fallacies of clinical studies on folic acid hazards in subjects with a low vitamin B12 status
- (2020) Jan D. van Gool et al. CRITICAL REVIEWS IN TOXICOLOGY
- Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease
- (2020) José M. López et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rise in serum folate after androgen deprivation associated with worse prostate cancer-specific survival
- (2020) Michael A. Liss et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
- (2020) Hongjuan Fu et al. DIGESTIVE DISEASES AND SCIENCES
- Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism
- (2020) Marta Cosín-Tomás et al. Nutrients
- High folic acid or folate combined with low vitamin B-12 status: potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES
- (2020) Regan L Bailey et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- A prospective birth cohort study on cord blood folate subtypes and risk of autism spectrum disorder
- (2020) Ramkripa Raghavan et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop
- (2020) Padma Maruvada et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability
- (2020) Won Dong Lee et al. Cell Metabolism
- [6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth
- (2020) Emanuela Pannia et al. Nutrients
- Choline and Folic Acid in Diets Consumed during Pregnancy Interact to Program Food Intake and Metabolic Regulation of Male Wistar Rat Offspring
- (2020) Rola Hammoud et al. JOURNAL OF NUTRITION
- Folate intake and the risk of breast cancer: an up-to-date meta-analysis of prospective studies
- (2019) Jie Zeng et al. EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Joint effects of folate and vitamin B12 imbalance with maternal characteristics on gestational diabetes mellitus
- (2019) Shuying Li et al. Journal of Diabetes
- Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion
- (2019) Yasmine J. Liu et al. PLoS Genetics
- Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases
- (2019) Barbara Frigerio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Folate Repletion after Deficiency Induces Irreversible Genomic and Transcriptional Changes in Human Papillomavirus Type 16 (HPV16)-Immortalized Human Keratinocytes
- (2019) Claudia Savini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Excess Folic Acid Supplementation Before and During Pregnancy and Lactation Activates Fos Gene Expression and Alters Behaviors in Male Mouse Offspring
- (2019) Dandan Chu et al. Frontiers in Neuroscience
- Folate/homocysteine metabolism and lung cancer risk among smokers
- (2019) Anna Stanisławska-Sachadyn et al. PLoS One
- Maternal and Cord Blood Folate Concentrations Are Inversely Associated with Fetal DNA Hydroxymethylation, but Not DNA Methylation, in a Cohort of Pregnant Canadian Women
- (2019) Lesley Plumptre et al. JOURNAL OF NUTRITION
- Paternal chronic folate supplementation induced the transgenerational inheritance of acquired developmental and metabolic changes in chickens
- (2019) Shengru Wu et al. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Folate can promote the methionine-dependent reprogramming of glioblastoma cells towards pluripotency
- (2019) Racha Zgheib et al. Cell Death & Disease
- Periconceptional folic acid and risk for neural tube defects among higher risk pregnancies
- (2019) Julie M. Petersen et al. Birth Defects Research
- Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)
- (2019) Helene McNulty et al. BMC Medicine
- Methyl donor deficiency blocks colorectal cancer development by affecting key metabolic pathways
- (2019) Matthew P Hanley et al. Cancer Prevention Research
- Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats
- (2019) Wansu Qiu et al. JOURNAL OF NEUROENDOCRINOLOGY
- The Associations between the Duration of Folic Acid Supplementation, Gestational Diabetes Mellitus, and Adverse Birth Outcomes based on a Birth Cohort
- (2019) Gang Cheng et al. International Journal of Environmental Research and Public Health
- Association of maternal folate status in the second trimester of pregnancy with the risk of gestational diabetes mellitus
- (2019) Kaipeng Xie et al. Food Science & Nutrition
- Demographic, Physiologic, and Lifestyle Characteristics Observed with Serum Total Folate Differ Among Folate Forms: Cross-Sectional Data from Fasting Samples in the NHANES 2011–2016
- (2019) Zia Fazili et al. JOURNAL OF NUTRITION
- Gene-specific DNA methylation in newborns in response to folic acid supplementation during the second and third trimesters of pregnancy: epigenetic analysis from a randomized controlled trial
- (2018) Aoife Caffrey et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Folate Nutrition Status in Mothers of the Boston Birth Cohort, Sample of a US Urban Low-Income Population
- (2018) Tina L. Cheng et al. AMERICAN JOURNAL OF PUBLIC HEALTH
- The effects of folate supplementation on glucose metabolism and risk of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
- (2018) Jie V. Zhao et al. ANNALS OF EPIDEMIOLOGY
- Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
- (2018) Amanda M. Henderson et al. FASEB JOURNAL
- Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation
- (2018) Mahmoud Aarabi et al. HUMAN MOLECULAR GENETICS
- The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)
- (2018) Rebecca C Richmond et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Folate Deficiency Facilitates Genomic Integration of Human Papillomavirus Type 16 DNA In Vivo in a Novel Mouse Model for Rapid Oncogenic Transformation of Human Keratinocytes
- (2018) Suhong Xiao et al. JOURNAL OF NUTRITION
- Maternal oversupplementation with folic acid and its impact on neurodevelopment of offspring
- (2018) Lauren K Murray et al. NUTRITION REVIEWS
- Circulating folic acid in plasma: relation to folic acid fortification
- (2018) Renee D Kalmbach et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Among Vitamin B12 Deficient Older People, High Folate Levels are Associated with Worse Cognitive Function: Combined Data from Three Cohorts
- (2018) Eileen M. Moore et al. JOURNAL OF ALZHEIMERS DISEASE
- Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial
- (2018) Sadaf Oliai Araghi et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
- (2017) Curtis J. Henry et al. HAEMATOLOGICA
- Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors
- (2017) Charalambos Kaittanis et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Efficacy of Folic Acid Therapy in Patients with Hyperhomocysteinemia
- (2017) Huizi Tian et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- Association between Serum Unmetabolized Folic Acid Concentrations and Folic Acid from Fortified Foods
- (2017) Cecília Zanin Palchetti et al. JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
- Interaction between excess folate and low vitamin B12 status
- (2017) Ligi Paul et al. MOLECULAR ASPECTS OF MEDICINE
- Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation
- (2017) Lundi Ly et al. MOLECULAR HUMAN REPRODUCTION
- Maternal Multivitamin Intake, Plasma Folate and Vitamin B12 Levels and Autism Spectrum Disorder Risk in Offspring
- (2017) Ramkripa Raghavan et al. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
- Association of prenatal folate status with early childhood wheeze and atopic dermatitis
- (2017) A. Roy et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Folate rescues vitamin B12depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability
- (2017) Ashley M. Palmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Associations between Folate and Vitamin B12 Levels and Inflammatory Bowel Disease: A Meta-Analysis
- (2017) Yun Pan et al. Nutrients
- Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis
- (2017) Curtis J. Henry et al. HAEMATOLOGICA
- Folate and vitamin B12 status is associated with insulin resistance and metabolic syndrome in morbid obesity
- (2017) Zhen Li et al. CLINICAL NUTRITION
- High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
- (2017) Kristin S. Henzel et al. Scientific Reports
- Maternal and postweaning folic acid supplementation interact to influence body weight, insulin resistance, and food intake regulatory gene expression in rat offspring in a sex-specific manner
- (2016) Pedro S.P. Huot et al. Applied Physiology Nutrition and Metabolism
- Excessive folic acid intake and relation to adverse health outcome
- (2016) Jacob Selhub et al. BIOCHIMIE
- Folic Acid Supplement Intake in Early Pregnancy Increases Risk of Gestational Diabetes Mellitus: Evidence From a Prospective Cohort Study
- (2016) Beibei Zhu et al. DIABETES CARE
- What is the safe upper intake level of folic acid for the nervous system? Implications for folic acid fortification policies
- (2016) E H Reynolds EUROPEAN JOURNAL OF CLINICAL NUTRITION
- Serum folate concentrations and all-cause, cardiovascular disease and cancer mortality: A cohort study based on 1999–2010 National Health and Nutrition Examination Survey (NHANES)
- (2016) Yang Peng et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Folic Acid Is Able to Polarize the Inflammatory Response in LPS Activated Microglia by Regulating Multiple Signaling Pathways
- (2016) Antonia Cianciulli et al. MEDIATORS OF INFLAMMATION
- Folate deficiency and over-supplementation causes impaired folate metabolism: Regulation and adaptation mechanisms inCaenorhabditis elegans
- (2016) Martina Ortbauer et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Folate Receptor Alpha Upregulates Oct4 , Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells
- (2016) Vineet Mohanty et al. STEM CELLS
- The interplay between DNA methylation, folate and neurocognitive development
- (2016) Rachelle E Irwin et al. Epigenomics
- Excess Folic Acid Increases Lipid Storage, Weight Gain, and Adipose Tissue Inflammation in High Fat Diet-Fed Rats
- (2016) Karen Kelly et al. Nutrients
- Folate intake and the risk of endometrial cancer: A meta-analysis
- (2016) Li Du et al. Oncotarget
- Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta‐Analysis of Randomized Controlled Trials
- (2016) Yanping Li et al. Journal of the American Heart Association
- DNA Methylation Profiling at Single-Base Resolution Reveals Gestational Folic Acid Supplementation Influences the Epigenome of Mouse Offspring Cerebellum
- (2016) Subit Barua et al. Frontiers in Neuroscience
- Periconceptional Folic Acid Use and the Prevalence of Positional Plagiocephaly
- (2016) Alice Michels et al. JOURNAL OF CRANIOFACIAL SURGERY
- High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice
- (2015) Karen E Christensen et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood
- (2015) Lesley Plumptre et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Prevalence and correlates of high red blood cell folate concentrations in the Canadian population using 3 proposed cut-offs
- (2015) Cynthia K. Colapinto et al. Applied Physiology Nutrition and Metabolism
- A high multivitamin diet fed to Wistar rat dams during pregnancy increases maternal weight gain later in life and alters homeostatic, hedonic and peripheral regulatory systems of energy balance
- (2015) Emanuela Pannia et al. BEHAVIOURAL BRAIN RESEARCH
- Hypercysteinemia promotes atherosclerosis by reducing protein S-nitrosylation
- (2015) Yulong Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy
- (2015) Barbara Anne Jennings et al. CANCER LETTERS
- Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha
- (2015) Mariann F. Hansen et al. CELLULAR SIGNALLING
- Maternal Folic Acid Supplementation During Pregnancy and Early Childhood Asthma
- (2015) Sreenivas P. Veeranki et al. EPIDEMIOLOGY
- Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial
- (2015) Rima Obeid et al. EUROPEAN JOURNAL OF NUTRITION
- High dose of maternal folic acid supplementation is associated to infant asthma
- (2015) Liu Yang et al. FOOD AND CHEMICAL TOXICOLOGY
- Maternal folate status and obesity/insulin resistance in the offspring: a systematic review
- (2015) R-h Xie et al. INTERNATIONAL JOURNAL OF OBESITY
- Excess perigestational folic acid exposure induces metabolic dysfunction in post-natal life
- (2015) E. Keating et al. JOURNAL OF ENDOCRINOLOGY
- High Gestational Folic Acid Supplementation Alters Expression of Imprinted and Candidate Autism Susceptibility Genes in a sex-Specific Manner in Mouse Offspring
- (2015) Subit Barua et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Systematic review of adverse health outcomes associated with high serum or red blood cell folate concentrations
- (2015) Cynthia K. Colapinto et al. JOURNAL OF PUBLIC HEALTH
- Cognitive Status According to Homocysteine and B-Group Vitamins in Elderly Adults
- (2015) Francesco Bonetti et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies
- (2015) Chun-Ting Kuo et al. Scientific Reports
- Folic acid handling by the human gut: implications for food fortification and supplementation
- (2014) Imran Patanwala et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Association of Folic Acid Supplementation During Pregnancy and Infant Bronchiolitis
- (2014) S. P. Veeranki et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis
- (2014) P Chen et al. BRITISH JOURNAL OF CANCER
- Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study
- (2014) M Köbel et al. BRITISH JOURNAL OF CANCER
- Folate intake and the risk of oral cavity and pharyngeal cancer: A pooled analysis within the International Head and Neck Cancer Epidemiology Consortium
- (2014) Carlotta Galeone et al. INTERNATIONAL JOURNAL OF CANCER
- Maternal homocysteine in pregnancy and offspring birthweight: epidemiological associations and Mendelian randomization analysis
- (2014) Chittaranjan S Yajnik et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Maternal High Folic Acid Supplement Promotes Glucose Intolerance and Insulin Resistance in Male Mouse Offspring Fed a High-Fat Diet
- (2014) Yifan Huang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Unmetabolized Folic Acid Is Detected in Nearly All Serum Samples from US Children, Adolescents, and Adults
- (2014) Christine M Pfeiffer et al. JOURNAL OF NUTRITION
- Maternal high-dose folic acid during pregnancy and asthma medication in the offspring
- (2014) Priscilla A. Zetstra-van der Woude et al. PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
- Folic Acid Supplementation Promotes Mammary Tumor Progression in a Rat Model
- (2014) Shaidah Deghan Manshadi et al. PLoS One
- Folate Intake and the Risk of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Studies
- (2014) Yu-Fei Zhang et al. PLoS One
- Association between Folate Intake and the Risk of Lung Cancer: A Dose-Response Meta-Analysis of Prospective Studies
- (2014) Yu-Fei Zhang et al. PLoS One
- Increasing Maternal or Post-Weaning Folic Acid Alters Gene Expression and Moderately Changes Behavior in the Offspring
- (2014) Subit Barua et al. PLoS One
- Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid
- (2014) Subit Barua et al. Epigenetics & Chromatin
- Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life
- (2014) Desirée Valera-Gran et al. JAMA Pediatrics
- Prenatal folic acid and risk of asthma in children: a systematic review and meta-analysis
- (2013) Krista S Crider et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Isolated atrioventricular canal defects: Birth outcomes and risk factors: A population-based hungarian case-control study, 1980-1996
- (2013) Attila Vereczkey et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Folic acid supplementation does not reduce intracellular homocysteine, and may disturb intracellular one-carbon metabolism
- (2013) Desirée E.C. Smith et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Association between maternal folate concentrations during pregnancy and insulin resistance in Indian children
- (2013) Ghattu V. Krishnaveni et al. DIABETOLOGIA
- High folate gestational and post-weaning diets alter hypothalamic feeding pathways by DNA methylation in Wistar rat offspring
- (2013) Clara E. Cho et al. Epigenetics
- Periconceptional folic acid associated with an increased risk of oral clefts relative to non-folate related malformations in the Northern Netherlands: a population based case-control study
- (2013) Anna M. Rozendaal et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Folic acid modulates eNOS activity via effects on posttranslational modifications and protein–protein interactions
- (2013) Sarah Y. Taylor et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies
- (2013) Huadong He et al. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
- Folate intake and the risk of upper gastrointestinal cancers: A systematic review and meta-analysis
- (2013) Martin Tio et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Use of micronutrient supplements among pregnant women in Alberta: results from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort
- (2013) Mariel Fajer Gómez et al. Maternal and Child Nutrition
- Folate intake and MTHFR polymorphism C677T is not associated with ovarian cancer risk: evidence from the meta-analysis
- (2013) Chenglin Li et al. MOLECULAR BIOLOGY REPORTS
- Effect of maternal and postweaning folic acid supplementation on global and gene-specific DNA methylation in the liver of the rat offspring
- (2013) Karen K. Y. Sie et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Risk Factors in the Origin of Congenital Left-Ventricular Outflow-Tract Obstruction Defects of the Heart: A Population-Based Case–Control Study
- (2013) Melinda Csáky-Szunyogh et al. PEDIATRIC CARDIOLOGY
- Prenatal Methyl-Donor Supplementation Augments Colitis in Young Adult Mice
- (2013) Sabina A. Mir et al. PLoS One
- Opposing Roles of Folate in Prostate Cancer
- (2013) Kevin J. Rycyna et al. UROLOGY
- High dose folic acid supplementation of rats alters synaptic transmission and seizure susceptibility in offspring
- (2013) Fernando Girotto et al. Scientific Reports
- High Dosage Folic Acid Supplementation, Oral Cleft Recurrence and Fetal Growth
- (2013) George Wehby et al. International Journal of Environmental Research and Public Health
- Folate in pregnancy and imprinted gene and repeat element methylation in the offspring
- (2012) Paul Haggarty et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Moderately high intake of folic acid has a negative impact on mouse embryonic development
- (2012) Leonie G. Mikael et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Folic acid supplementation in pregnancy: are there devils in the detail?
- (2012) Graham C. Burdge et al. BRITISH JOURNAL OF NUTRITION
- Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice
- (2012) K. Kadaveru et al. Cancer Prevention Research
- Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro
- (2012) Michelle A. Charles et al. Epigenetics
- Efficacy of folic acid supplementation in cardiovascular disease prevention: An updated meta-analysis of randomized controlled trials
- (2012) Hsin-Ta Yang et al. European Journal of Internal Medicine
- High Circulating Folate and Vitamin B-12 Concentrations in Women During Pregnancy Are Associated with Increased Prevalence of Atopic Dermatitis in Their Offspring
- (2012) Jessica C. Kiefte-de Jong et al. JOURNAL OF NUTRITION
- Estimation of Trends in Serum and RBC Folate in the U.S. Population from Pre- to Postfortification Using Assay-Adjusted Data from the NHANES 1988–2010
- (2012) Christine M. Pfeiffer et al. JOURNAL OF NUTRITION
- Vitamin B-12 and Folate Status in Relation to Decline in Scores on the Mini-Mental State Examination in the Framingham Heart Study
- (2012) Martha Savaria Morris et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Effect of maternal folic acid supplementation on hepatic proteome in newborn piglets
- (2012) Jingbo Liu et al. NUTRITION
- Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother–child cohort ‘Rhea’ study in Crete, Greece
- (2012) Leda Chatzi et al. PUBLIC HEALTH NUTRITION
- Nuclear localization of folate receptor alpha: a new role as a transcription factor
- (2012) Vanda Boshnjaku et al. Scientific Reports
- Cancer risk with folic acid supplements: a systematic review and meta-analysis
- (2012) Tale Norbye Wien et al. BMJ Open
- Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency
- (2012) Rita Rosati et al. Journal of Oncology
- The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood
- (2011) J. A. Dunstan et al. ALLERGY
- Folic acid supplementation in early pregnancy and asthma in children aged 6 years
- (2011) Marit P. Martinussen et al. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
- Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
- (2011) Cathrine Hoyo et al. BMC PUBLIC HEALTH
- Maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids: Implications for neurodevelopmental risk in the rat offspring
- (2011) Suchitra Roy et al. BRAIN & DEVELOPMENT
- Periconceptional folic acid supplementation and anthropometric measures at birth in a cohort of pregnant women in Valencia, Spain
- (2011) Maria Pastor-Valero et al. BRITISH JOURNAL OF NUTRITION
- Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis
- (2011) P. Protiva et al. Cancer Prevention Research
- Methylation variation atIGF2differentially methylated regions and maternal folic acid use before and during pregnancy
- (2011) Cathrine Hoyo et al. Epigenetics
- Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes
- (2011) Tiffany D. Schaible et al. HUMAN MOLECULAR GENETICS
- An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling
- (2011) D. J. Kominsky et al. JOURNAL OF IMMUNOLOGY
- Altered brain neurotrophins at birth: consequence of imbalance in maternal folic acid and vitamin B12 metabolism
- (2011) P. Sable et al. NEUROSCIENCE
- Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts
- (2011) Z-L Jia et al. ORAL DISEASES
- Folic Acid Use in Pregnancy and the Development of Atopy, Asthma, and Lung Function in Childhood
- (2011) F. J. H. Magdelijns et al. PEDIATRICS
- Effects of Altered Maternal Folic Acid, Vitamin B12 and Docosahexaenoic Acid on Placental Global DNA Methylation Patterns in Wistar Rats
- (2011) Asmita Kulkarni et al. PLoS One
- Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions
- (2011) Krista S. Crider et al. Nutrients
- A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy
- (2010) Paula Tighe et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- High intake of folic acid disrupts embryonic development in mice
- (2010) Laura Pickell et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Folate status of the population in the Canadian Health Measures Survey
- (2010) C. K. Colapinto et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Effect of Maternal and Postweaning Folic Acid Supplementation on Mammary Tumor Risk in the Offspring
- (2010) A. Ly et al. CANCER RESEARCH
- Significant Evidence of Association Between Polymorphisms in ZNF533, Environmental Factors, and Nonsyndromic Orofacial Clefts in the Western Han Chinese Population
- (2010) Jun Wu et al. DNA AND CELL BIOLOGY
- Total folate and folic acid intake from foods and dietary supplements in the United States: 2003–2006
- (2009) Regan L Bailey et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Effect of Supplemental Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study
- (2009) M. J. Whitrow et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Gene expression profiling in the fetal cardiac tissue after folate and low-dose trichloroethylene exposure
- (2009) Patricia T. Caldwell et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci
- (2009) G. M. Lindzon et al. CARCINOGENESIS
- Relationship of homocysteine with other risk factors and outcome of ischemic stroke
- (2009) Jayantee Kalita et al. CLINICAL NEUROLOGY AND NEUROSURGERY
- Cancer Incidence and Mortality After Treatment With Folic Acid and Vitamin B12
- (2009) Marta Ebbing JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Folic Acid and Risk of Prostate Cancer: Results From a Randomized Clinical Trial
- (2009) J. C. Figueiredo et al. JNCI-Journal of the National Cancer Institute
- Folate stimulates ERK1/2 phosphorylation and cell proliferation in fetal neural stem cells
- (2009) Xu-Mei Zhang et al. NUTRITIONAL NEUROSCIENCE
- The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake
- (2009) S. W. Bailey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Folic acid supplements in pregnancy and early childhood respiratory health
- (2008) S E Haberg et al. ARCHIVES OF DISEASE IN CHILDHOOD
- Folate and Clefts of the Lip and Palate—A U.K.-Based Case-Control Study: Part I: Dietary and Supplemental Folate
- (2008) J. Little et al. CLEFT PALATE-CRANIOFACIAL JOURNAL
- Effect of In Utero and Early-Life Conditions on Adult Health and Disease
- (2008) Peter D. Gluckman et al. NEW ENGLAND JOURNAL OF MEDICINE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started