A comprehensive review of genetic causes of obesity

Clinical Trials in Prader–Willi Syndrome: A Review

(2023) Ranim Mahmoud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The gut microbiota in obesity and weight management: microbes as friends or foe?

(2023) Matthias Van Hul et al.   Nature Reviews Endocrinology

Metabolic and Bariatric Surgery for Obesity in Prader Willi Syndrome: Systematic Review and Meta-Analysis

(2023) Gunnar Wolfe et al.   Surgery for Obesity and Related Diseases

Bardet-Biedl Syndrome: Current Perspectives and Clinical Outlook

(2023) Andrea Melluso et al.   Therapeutics and Clinical Risk Management

Novel multi-allelic variants, two BBS2 and one PKD1 variant, of renal ciliopathies: A case report and literature review

(2023) Fazhan Zhong et al.   European Journal of Medical Genetics

A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review

(2023) Özge Besci et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A randomized‐controlled trial to evaluate the app‐based multimodal weight loss program zanadio for patients with obesity

(2023) Lena Roth et al.   Obesity

The Genetic Basis of Childhood Obesity: A Systematic Review

(2023) Aikaterini Vourdoumpa et al.   Nutrients

Pharmacotherapy of obesity: an update on the available medications and drugs under investigation

(2023) Marlene Chakhtoura et al.   EClinicalMedicine

Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

(2023) Ania M. Jastreboff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crosstalk between Melanin Concentrating Hormone and Endocrine Factors: Implications for Obesity

(2022) Eva Prida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Overview of Epigenetics in Obesity: The Role of Lifestyle and Therapeutic Interventions

(2022) Abeer M. Mahmoud   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteins and Proteases of Prader-Willi Syndrome: A Comprehensive Review and Perspectives

(2022) Sanjukta Basak et al.   BIOSCIENCE REPORTS

A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on

(2022) Chrysoula Boutari et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Critical review of bariatric surgical outcomes in patients with Prader‐Willi syndrome and other hyperphagic disorders

(2022) Marie G. Gantz et al.   Obesity

Rapid and Lasting Effects of Activating BDNF-Expressing PVH Neurons on Energy Balance

(2022) Shaw-wen Wu et al.   eNeuro

Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant

(2022) Eline S van der Valk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recommendations for the diagnosis and management of childhood Prader-Willi syndrome in China

(2022) Dai Yang-Li et al.   Orphanet Journal of Rare Diseases

Gut microbes and food reward: From the gut to the brain

(2022) Alice de Wouters d’Oplinter et al.   Frontiers in Neuroscience

Genetics of Obesity in Humans: A Clinical Review

(2022) Ranim Mahmoud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liraglutide for Weight Management in Children and Adolescents With Prader–Willi Syndrome and Obesity

(2022) Gwenaëlle Diene et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cohen syndrome in two patients from China

(2022) Jiaoe Gong et al.   Molecular Genetics & Genomic Medicine

Glucagon-like Peptide-1 Receptor in the Human Hypothalamus Is Associated with Body Mass Index and Colocalizes with the Anorexigenic Neuropeptide Nucleobindin-2/Nesfatin-1

(2022) Aristea Psilopanagioti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NGF and BDNF in pediatrics syndromes

(2022) Giampiero Ferraguti et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Obesity and Overweight Among Children With Medical Complexity

(2022) Maria I. Peinado Fabregat et al.   PEDIATRICS

Recent progress in epigenetics of obesity

(2022) Feng-Yao Wu et al.   Diabetology & Metabolic Syndrome

Efficacy and safety of setmelanotide, a melanocortin-4 receptor agonist, in patients with Bardet-Biedl syndrome and Alström syndrome: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial with an open-label period

(2022) Andrea M Haqq et al.   Lancet Diabetes & Endocrinology

Adipose Tissue Malfunction Drives Metabolic Dysfunction in Alström Syndrome

(2021) Sona Kang   DIABETES

A Rare Potential Pathogenic Variant in the BDNF Gene is Found in a Brazilian Patient with Severe Childhood-Onset Obesity

(2021) Ana Carolina Proença da Fonseca et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Hypogonadism in Patients with Prader Willi Syndrome: A Narrative Review

(2021) Luigi Napolitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prader–Willi Syndrome and Hypogonadism: A Review Article

(2021) Cees Noordam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association of Gut Hormones and Microbiota with Vascular Dysfunction in Obesity

(2021) Valentina Rovella et al.   Nutrients

The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It

(2021) Jesús Devesa   Frontiers in Endocrinology

Long-term outcome of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR and MC4R gene

(2021) Christine Poitou et al.   Surgery for Obesity and Related Diseases

Pediatric Metabolic and Bariatric Surgery

(2021) Adi Steinhart et al.   SURGICAL CLINICS OF NORTH AMERICA

Metabolic homeostasis via BDNF and its receptors

(2021) Brandon Podyma et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Novel Homozygous Inactivating Mutation in the PCSK1 Gene in an Infant with Congenital Malabsorptive Diarrhea

(2021) Laetitia Aerts et al.   Genes

Obesity in Prader–Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches

(2021) G. Muscogiuri et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome

(2021) Silvia Bettini et al.   Diagnostics

Obesity, POMC, and POMC-processing enzymes: surprising results from animal models

(2021) Iris Lindberg et al.   ENDOCRINOLOGY

The genetics of obesity: from discovery to biology

(2021) Ruth J. F. Loos et al.   NATURE REVIEWS GENETICS

The gut microbiota as a therapeutic target for obesity: a scoping review

(2021) Stephanie Santos-Paulo et al.   NUTRITION RESEARCH REVIEWS

Characteristics of gut microbiota in people with obesity

(2021) Mengmeng Duan et al.   PLoS One

Childhood Obesity

(2021) Neena Thomas-Eapen   PRIMARY CARE

Gut microbiota: a target for intervention in obesity

(2021) Kanika Sehgal et al.   Expert Review of Gastroenterology & Hepatology

Update on pediatric metabolic and bariatric surgery

(2021) Dani O. Gonzalez et al.   Pediatric Obesity

Two Cases With an Early Presented Proopiomelanocortin Deficiency—A Long-Term Follow-Up and Systematic Literature Review

(2021) Nadan Gregoric et al.   Frontiers in Endocrinology

When Leptin Is Not There: A Review of What Nonsyndromic Monogenic Obesity Cases Tell Us and the Benefits of Exogenous Leptin

(2021) Kaio Cezar Rodrigues Salum et al.   Frontiers in Endocrinology

Evaluation and Management of Early Onset Genetic Obesity in Childhood

(2021) Sonali Malhotra et al.   Journal of Pediatric Genetics

Expansion of the phenotypic and mutational spectrum of Carpenter syndrome

(2021) Rabab Khairat et al.   European Journal of Medical Genetics

Oxytocin and Food Intake Control: Neural, Behavioral, and Signaling Mechanisms

(2021) Clarissa M. Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phylogenetic and Molecular Analyses Identify SNORD116 Targets Involved in the Prader–Willi Syndrome

(2021) Laeya Baldini et al.   MOLECULAR BIOLOGY AND EVOLUTION

Oxytocin as an Anti-obesity Treatment

(2021) JingJing Niu et al.   Frontiers in Neuroscience

Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review

(2021) Justin Matheson et al.   Pharmaceuticals

Prader-Willi syndrome: an update on obesity and endocrine problems

(2021) Su Jin Kim et al.   Annals of Pediatric Endocrinology & Metabolism

Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical characteristics

(2020) Ayça Aykut et al.   EUROPEAN JOURNAL OF PEDIATRICS

ROHHAD(NET) Syndrome: Systematic review of the clinical timeline and recommendations for diagnosis and prognosis

(2020) Julie Harvengt et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Novel Missense Variant in PHF6 Gene Causing Börjeson-Forssman-Lehman Syndrome

(2020) Anikha Bellad et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Cilia signaling and obesity

(2020) Staci E. Engle et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Firmicutes/Bacteroidetes Ratio: A Relevant Marker of Gut Dysbiosis in Obese Patients?

(2020) Fabien Magne et al.   Nutrients

Genetic Determinants of Childhood Obesity

(2020) Sheridan H. Littleton et al.   Molecular Diagnosis & Therapy

BDNF influences neural cue-reactivity to food stimuli and food craving in obesity

(2020) Jan Malte Bumb et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Leptin resistance: underlying mechanisms and diagnosis

(2019) Olga Gruzdeva et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Thyroid function in patients with Prader-Willi syndrome: an Italian multicenter study of 339 patients

(2019) Lorenzo Iughetti et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

(2019) Magdalena Miranda et al.   Frontiers in Cellular Neuroscience

Bariatric surgery for Prader‐Willi syndrome was ineffective in producing sustainable weight loss: Long term results for up to 10 years

(2019) Shirley Yuk‐Wah Liu et al.   Pediatric Obesity

Leptin receptor deficiency: a systematic literature review and prevalence estimation based on population genetics

(2019) Lotte Kleinendorst et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity

(2019) M.I. Cooiman et al.   OBESITY SURGERY

Metabolic and Bariatric Surgery for Pediatric Patients With Severe Obesity

(2019) Christopher F. Bolling et al.   PEDIATRICS

Pediatric Metabolic and Bariatric Surgery: Evidence, Barriers, and Best Practices

(2019) Sarah C. Armstrong et al.   PEDIATRICS

Clinical, molecular genetics and therapeutic aspects of syndromic obesity

(2018) E. Geets et al.   CLINICAL GENETICS

Finding treatable genetic obesity

(2018) Kristin Dayton et al.   CURRENT OPINION IN PEDIATRICS

Pediatric obesity: Current concepts

(2018) Donald E. Greydanus et al.   DM DISEASE-A-MONTH

The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite

(2018) Renger F. Witkamp   MOLECULAR ASPECTS OF MEDICINE

ASMBS pediatric metabolic and bariatric surgery guidelines, 2018

(2018) Janey S.A. Pratt et al.   Surgery for Obesity and Related Diseases

Oxytocin curbs calorie intake via food-specific increases in the activity of brain areas that process reward and establish cognitive control

(2018) Maartje S. Spetter et al.   Scientific Reports

Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis

(2018) Leonardo Sandrini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The epidemiology of obesity

(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Genetics and epigenetics in obesity

(2018) Kerstin Rohde et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Rapid-Onset Obesity with Hypoventilation, Hypothalamic, Autonomic Dysregulation, and Neuroendocrine Tumors (ROHHADNET) Syndrome: A Systematic Review

(2018) Jiwon M. Lee et al.   Biomed Research International

Leptin Functions in Infectious Diseases

(2018) Radheshyam Maurya et al.   Frontiers in Immunology

Obesity management in Prader–Willi syndrome: current perspectives

(2018) Antonino Crinò et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Genetic and Syndromic Causes of Obesity and its Management

(2017) Ildiko H. Koves et al.   INDIAN JOURNAL OF PEDIATRICS

Complex Relationship between Obesity and the Fat Mass and Obesity Locus

(2017) Qingyun Yang et al.   International Journal of Biological Sciences

Review of Childhood Obesity

(2017) Seema Kumar et al.   MAYO CLINIC PROCEEDINGS

Next-generation sequencing of the monogenic obesity genes LEP , LEPR , MC4R , PCSK1 and POMC in a Norwegian cohort of patients with morbid obesity and normal weight controls

(2017) Gry B.N. Nordang et al.   MOLECULAR GENETICS AND METABOLISM

A systematic review of genetic syndromes with obesity

(2017) Y. Kaur et al.   Obesity Reviews

Fragile X syndrome

(2017) Randi J. Hagerman et al.   Nature Reviews Disease Primers

A novel MC4R mutation associated with childhood-onset obesity: A case report

(2017) Manpreet Doulla et al.   Paediatrics & Child Health

Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity

(2016) Muhammad Wasim et al.   BIOCHEMICAL GENETICS

Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity

(2016) M. Pigeyre et al.   CLINICAL SCIENCE

PCSK1 Mutations and Human Endocrinopathies: From Obesity to Gastrointestinal Disorders

(2016) Pieter Stijnen et al.   ENDOCRINE REVIEWS

Obesity Epidemiology Worldwide

(2016) Cassandra Arroyo-Johnson et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Bardet–Biedl syndrome: Genetics, molecular pathophysiology, and disease management

(2016) Sathya Priya et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota

(2016) Alok Kumar Mishra et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016

(2016) Hélène Huvenne et al.   Obesity Facts

Snord116 is critical in the regulation of food intake and body weight

(2016) Yue Qi et al.   Scientific Reports

Brain-derived neurotrophic factor and its clinical implications

(2015) Siresha Bathina et al.   Archives of Medical Science

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Prader-Willi syndrome: a review of clinical, genetic, and endocrine findings

(2015) M. A. Angulo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The Association of Common Variants in PCSK1 With Obesity: A HuGE Review and Meta-Analysis

(2014) Pieter Stijnen et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Epidemiology of fragile X syndrome: A systematic review and meta-analysis

(2014) Jessica Hunter et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The fat mass and obesity-associated (FTO) gene: Obesity and beyond?

(2014) Martin E. Hess et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Controversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4R

(2014) Dörthe Malzahn et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Physical Activity, Food Intake, Eating Behaviors, Psychological Health, and Modeled Change in Body Mass Index in Overweight/Obese Caucasian Adults

(2014) Janetta Harbron et al.   Nutrients

Bariatric surgery for obese children and adolescents: a review of the moral challenges

(2013) Bjørn Hofmann   BMC Medical Ethics

Bariatric surgery in monogenic and syndromic forms of obesity

(2013) Aayed R. Alqahtani et al.   Seminars in Pediatric Surgery

Genetic determinants of common obesity and their value in prediction

(2012) Ruth J.F. Loos   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Prader-Willi Syndrome: Obesity due to Genomic Imprinting

(2012) Merlin G. Butler   CURRENT GENOMICS

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Ghrelin Level and Weight Loss After Laparoscopic Sleeve Gastrectomy and Gastric Mini-Bypass for Prader–Willi Syndrome in Chinese

(2012) Anthony K. W. Fong et al.   OBESITY SURGERY

The endocannabinoid system: Its roles in energy balance and potential as a target for obesity treatment

(2010) Aurore André et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genomic insights into early-onset obesity

(2010) Hélène Choquet et al.   Genome Medicine

Brain-Derived Neurotrophic Factor and Obesity in the WAGR Syndrome

(2008) Joan C. Han et al.   NEW ENGLAND JOURNAL OF MEDICINE