Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review

What Role Does the Endocannabinoid System Play in the Pathogenesis of Obesity?

(2021) Piotr Schulz et al.   Nutrients

Diet-induced obesity in animal models: points to consider and influence on metabolic markers

(2021) Mariana de Moura e Dias et al.   Diabetology & Metabolic Syndrome

The genetics of obesity: from discovery to biology

(2021) Ruth J. F. Loos et al.   NATURE REVIEWS GENETICS

Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase

(2020) Carlo Cifani et al.   Frontiers in Pharmacology

Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity

(2020) Tina K. Thethi et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

The association of dietary patterns with endocannabinoids levels in overweight and obese women

(2020) Neda Lotfi Yagin et al.   Lipids in Health and Disease

Targeting the Endocannabinoid CB1 Receptor to Treat Body Weight Disorders: A Preclinical and Clinical Review of the Therapeutic Potential of Past and Present CB1 Drugs

(2020) Thomas Murphy et al.   Biomolecules

The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

(2020) Mark E. Schmidt et al.   NEUROPSYCHOPHARMACOLOGY

Understanding the possible role of endocannabinoid system in obesity

(2020) Tapan Behl et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

(2019) Matteo Tardelli et al.   JOURNAL OF LIPID RESEARCH

The influence of the fatty acid amide hydrolase 385C>A single nucleotide polymorphisms on obesity susceptibility

(2019) Neda Lotfi Yagin et al.   MOLECULAR BIOLOGY REPORTS

Glucose Increase DAGLα Levels in Tanycytes and Its Inhibition Alters Orexigenic and Anorexigenic Neuropeptides Expression in Response to Glucose

(2019) Alejandra Palma-Chavez et al.   Frontiers in Endocrinology

D3 dopamine receptors and a missense mutation of fatty acid amide hydrolase linked in mouse and men: implication for addiction

(2019) Esmaeil Mansouri et al.   NEUROPSYCHOPHARMACOLOGY

N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis

(2019) Trisha J. Grevengoed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced endocannabinoid tone as a potential target of pharmacotherapy

(2018) Marek Toczek et al.   LIFE SCIENCES

Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance

(2018) Georgia Balsevich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB1 cannabinoid receptor–deficient mice

(2018) Kenji Yoshida et al.   FASEB JOURNAL

Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans

(2018) Shahar Azar et al.   OBESITY SURGERY

Oleoylethanolamide: A novel pharmaceutical agent in the management of obesity‐an updated review

(2018) Payahoo Laleh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults

(2017) Leandra Abarca-Gómez et al.   LANCET

Sex-Dependent Effects of Cannabis and Cannabinoids: A Translational Perspective

(2017) Ziva D Cooper et al.   NEUROPSYCHOPHARMACOLOGY

An Introduction to the Endogenous Cannabinoid System

(2016) Hui-Chen Lu et al.   BIOLOGICAL PSYCHIATRY

Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis

(2016) Edward J. Wagner   FRONTIERS IN NEUROENDOCRINOLOGY

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Economic Impact of Obesity

(2016) Elena A. Spieker et al.   PRIMARY CARE

Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

(2015) John D. Douglass et al.   JOURNAL OF LIPID RESEARCH

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice

(2015) David R. Powell et al.   Frontiers in Endocrinology

Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture

(2015) Cyro José de Moraes Martins et al.   PLoS One

Effects of C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) on weight loss, adipocytokines levels, and insulin resistance after a high polyunsaturated fat diet in obese patients

(2014) D. A. de Luis et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Rimonabant: an antagonist drug of the endocannabinoid system for the treatment of obesity

(2014) Carlos E. Leite et al.   Pharmacological Reports

Lack of Association between C385A Functional Polymorphism of the Fatty Acid Amide Hydrolase Gene and Polycystic Ovary Syndrome

(2013) V. Grolmusz et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet

(2013) Daniel de Luis et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

(2012) Tiziana Bisogno et al.   BRITISH JOURNAL OF PHARMACOLOGY

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism

(2012) Kwang-Mook Jung et al.   Cell Metabolism

Relationship among metabolic syndrome, C358A polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance

(2012) D.A. de Luis et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Peripheral Effects of FAAH Deficiency on Fuel and Energy Homeostasis: Role of Dysregulated Lysine Acetylation

(2012) Bhavapriya Vaitheesvaran et al.   PLoS One

Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity

(2012) Isabelle Matias et al.   PLoS One

Over-Expression of Monoacylglycerol Lipase (MGL) in Small Intestine Alters Endocannabinoid Levels and Whole Body Energy Balance, Resulting in Obesity

(2012) Su-Hyoun Chon et al.   PLoS One

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

(2012) W. H. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A fast collapsed data method for estimating haplotype frequencies from pooled genotype data with applications to the study of rare variants

(2012) Anthony Y.C. Kuk et al.   STATISTICS IN MEDICINE

The Fatty Acid Amide Hydrolase (FAAH) Gene Variant rs324420 AA/AC is not Associated with Weight Loss in a 1-Year Lifestyle Intervention for Obese Children and Adolescents

(2011) N. Knoll et al.   HORMONE AND METABOLIC RESEARCH

Psychopharmacology of the endocannabinoids: far beyond anandamide

(2011) FA Pamplona et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Association of genetic variation in cannabinoid mechanisms and gastric motor functions and satiation in overweight and obesity

(2011) M. I. Vazquez-Roque et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity

(2010) Timo D Müller et al.   BMC Medical Genetics

C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and insulin resistance in patients with diabetes mellitus type 2

(2010) D.A. de Luis et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

C358A missense polymorphism of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) and visfatin levels in obese females

(2010) D A de Luis et al.   INTERNATIONAL JOURNAL OF OBESITY

An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity

(2010) F. D. Christopoulou et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide hydrolase on weight loss, adipocytokines, and insulin resistance after 2 hypocaloric diets

(2010) Daniel Antonio Deluis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet

(2010) Daniel Antonio de Luis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss and cardiovascular risk factors 1 year after biliopancreatic diversion surgery

(2010) D.A. de Luis et al.   Surgery for Obesity and Related Diseases

A Covering Method for Detecting Genetic Associations between Rare Variants and Common Phenotypes

(2010) Gaurav Bhatia et al.   PLoS Computational Biology

Population sequencing of two endocannabinoid metabolic genes identifies rare and common regulatory variants associated with extreme obesity and metabolite level

(2010) Olivier Harismendy et al.   GENOME BIOLOGY

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

FAAH deficiency promotes energy storage and enhances the motivation for food

(2009) C Touriño et al.   INTERNATIONAL JOURNAL OF OBESITY

Variants in theCNR1and theFAAHGenes and Adiposity Traits in the Community

(2009) Wolfgang Lieb et al.   Obesity

Obesity-related dyslipidemia associated withFAAH, independent of insulin response, in multigenerational families of Northern European descent

(2009) Yi Zhang et al.   PHARMACOGENOMICS

The future of endocannabinoid-oriented clinical research after CB1 antagonists

(2009) Bernard Le Foll et al.   PSYCHOPHARMACOLOGY

The psychiatric side-effects of rimonabant

(2009) Fabrício A. Moreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

The Fatty Acid Amide Hydrolase (FAAH) Pro129Thr Polymorphism is not Associated with Severe Obesity in Greek Subjects

(2008) D. Papazoglou et al.   HORMONE AND METABOLIC RESEARCH

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations

(2008) Michael Benzinou et al.   HUMAN MOLECULAR GENETICS

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

(2008) Mauro Maccarrone et al.   NATURE NEUROSCIENCE

Evaluating the Association of FAAH Common Gene Variation with Childhood, Adult Severe Obesity and Type 2 Diabetes in the French Population

(2008) Emmanuelle Durand et al.   Obesity Facts

The cDNA 385C to A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) is associated with overweight/obesity but not with binge eating disorder in overweight/obese women

(2008) Palmiero Monteleone et al.   PSYCHONEUROENDOCRINOLOGY