Human–gut bacterial protein–protein interactions: understudied but impactful to human health

Silent recognition of flagellins from human gut commensal bacteria by Toll-like receptor 5

(2023) Sara J. Clasen et al.   Science Immunology

Fusobacterium nucleatum aggravates rheumatoid arthritis through FadA-containing outer membrane vesicles

(2023) Mukeng Hong et al.   Cell Host & Microbe

Why do hosts malfunction without microbes? Missing benefits versus evolutionary addiction

(2023) Tobin J. Hammer   TRENDS IN MICROBIOLOGY

Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

(2022) Robert H. Mills et al.   Nature Microbiology

Artificial intelligence approaches to human-microbiome protein–protein interactions

(2022) Hansaim Lim et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

BefA, a microbiota-secreted membrane disrupter, disseminates to the pancreas and increases β cell mass

(2022) Jennifer Hampton Hill et al.   Cell Metabolism

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets

(2022) Yadi Zhou et al.   NATURE BIOTECHNOLOGY

Inflammatory Bowel Disease-Associated Gut Commensals Degrade Components of the Extracellular Matrix

(2022) Ana Maria Porras et al.   mBio

Gut microbiome ADP-ribosyltransferases are widespread phage-encoded fitness factors

(2021) Eric M. Brown et al.   Cell Host & Microbe

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Moonlighting Proteins

(2020) Nadia Singh et al.   Annual Review of Genetics

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Intestinal translocation of enterococci requires a threshold level of enterococcal overgrowth in the lumen

(2019) Cristel Archambaud et al.   Scientific Reports

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

(2019) Sunny H. Wong et al.   Nature Reviews Gastroenterology & Hepatology

Faecalibacterium prausnitzii ‐derived Microbial Anti‐inflammatory Molecule regulates intestinal integrity in diabetes mellitus mice via modulating tight junction protein expression

(2019) Jihao Xu et al.   Journal of Diabetes

The Diverse Functional Roles of Elongation Factor Tu (EF-Tu) in Microbial Pathogenesis

(2019) Kate L. Harvey et al.   Frontiers in Microbiology

Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation

(2018) Rishi Drolia et al.   Cell Host & Microbe

An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses

(2018) Bennett H. Penn et al.   MOLECULAR CELL

Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis

(2018) Mingming Sun et al.   Nature Communications

Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases

(2017) Julio Plaza-Díaz et al.   Nutrients

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Host-Microbe Protein Interactions during Bacterial Infection

(2015) Devin K. Schweppe et al.   CHEMISTRY & BIOLOGY

Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

(2015) E Quévrain et al.   GUT

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

(2015) Chamutal Gur et al.   IMMUNITY

Salmonellae interactions with host processes

(2015) Doris L. LaRock et al.   NATURE REVIEWS MICROBIOLOGY

Small molecules from the human microbiota

(2015) M. S. Donia et al.   SCIENCE

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

The human microbiome: at the interface of health and disease

(2012) Ilseung Cho et al.   NATURE REVIEWS GENETICS

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation

(2011) Natalie Steck et al.   GASTROENTEROLOGY

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

The Human-Bacterial Pathogen Protein Interaction Networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis

(2010) Matthew D. Dyer et al.   PLoS One

The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage

(2009) S. Nair et al.   JOURNAL OF IMMUNOLOGY

Barrier-protective function of intestinal epithelial Toll-like receptor 2

(2008) E Cario   Mucosal Immunology

S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions

(2008) S. R. Konstantinov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA