Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting

Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome.

(2023) Sicheng Zhang et al.   JOURNAL OF LIPID RESEARCH

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

(2022) Anne Loft et al.   Cell Metabolism

Environmental Enrichment and Estrogen Upregulate Beta-Hydroxybutyrate Underlying Functional Improvement

(2022) Soonil Pyo et al.   Frontiers in Molecular Neuroscience

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis

(2022) Allison J. Richard et al.   Frontiers in Endocrinology

Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

(2022) Gloria Ursino et al.   Nature Communications

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

(2022) Anne Fougerat et al.   Cell Reports

A reappraisal of the role of cyclic AMP in the physiological action of glucagon

(2022) Robert L. Rodgers   PEPTIDES

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

(2021) Sarra Smati et al.   GUT

mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis

(2021) Ebru S. Selen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

(2021) David B. Stagg et al.   Molecular Metabolism

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

(2021) Patrycja Puchalska et al.   Annual Review of Nutrition

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

(2020) Megan E. Capozzi et al.   DIABETES

Metabolic interactions between peroxisomes and mitochondria with a special focus on acylcarnitine metabolism

(2020) Sander M. Houten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Causes and Consequences of Hypertriglyceridemia

(2020) Chris J. Packard et al.   Frontiers in Endocrinology

FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs

(2020) Jose Miguel Ramos Pittol et al.   GASTROENTEROLOGY

Sex differences in the effect of acute fasting on excitatory and inhibitory synapses onto ventral tegmental area dopamine neurons

(2020) Nathan Godfrey et al.   JOURNAL OF PHYSIOLOGY-LONDON

Probing metabolic memory in the hepatic response to fasting

(2020) Merel Defour et al.   PHYSIOLOGICAL GENOMICS

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

(2020) J.J. Schlezinger et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

(2020) Philip M.M. Ruppert et al.   Molecular Metabolism

Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism

(2020) Stine M. Præstholm et al.   Frontiers in Endocrinology

The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive Impairment.

(2020) Étienne Myette-Côté et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Comparative Transcriptomics Analyses in Livers of Mice, Humans, and Humanized Mice Define Human-Specific Gene Networks

(2020) Chengfei Jiang et al.   Cells

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

(2019) Philip M. M. Ruppert et al.   BMC GENOMICS

Sex-based differences in hepatic and skeletal muscle triglyceride storage and metabolism

(2019) Kayleigh M Beaudry et al.   Applied Physiology Nutrition and Metabolism

Characterization of variable presentations of diabetic ketoacidosis based on blood ketone levels and major society diagnostic criteria: a new view point on the assessment of diabetic ketoacidosis

(2019) Kiyoung Lee et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Alterations in rat adipose tissue transcriptome and proteome in response to prolonged fasting

(2019) Marianne Ibrahim et al.   BIOLOGICAL CHEMISTRY

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

(2019) Kitt Falk Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

(2019) Fabiana Quagliarini et al.   MOLECULAR CELL

Sex Differences in Liver, Adipose Tissue, and Muscle Transcriptional Response to Fasting and Refeeding in Mice

(2019) Nadezhda Bazhan et al.   Cells

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

(2018) Montserrat A. de la Rosa Rodriguez et al.   BMC GENOMICS

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver

(2018) Sara Della Torre et al.   Cell Metabolism

Ketogenic diet-induced extension of longevity in epileptic Kcna1 -null mice is influenced by gender and age at treatment onset

(2018) Kyoung-chul Chun et al.   EPILEPSY RESEARCH

Mitochondrial β-oxidation of saturated fatty acids in humans

(2018) María M. Adeva-Andany et al.   MITOCHONDRION

Insights into the role of hepatocyte PPARα activity in response to fasting

(2018) Marion Régnier et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fasting decreases plasma FGF21 in obese subjects and the expression of FGF21 receptors in adipose tissue in both lean and obese subjects

(2018) Eva B. Nygaard et al.   JOURNAL OF ENDOCRINOLOGY

Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men

(2018) Ann Mosegaard Bak et al.   PLoS One

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion

(2017) William J. Quinn et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-induced extracellular cAMP regulates hepatic lipid metabolism

(2017) Sihan Lv et al.   JOURNAL OF ENDOCRINOLOGY

HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation

(2017) Xinchen Qiu et al.   JOURNAL OF LIPID RESEARCH

CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis

(2017) Hyunbae Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Induction of fibroblast growth factor 21 does not require activation of the hepatic X-box binding protein 1 in mice

(2017) Shantel Olivares et al.   Molecular Metabolism

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

(2017) Lili Guo et al.   Molecular Metabolism

Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

(2016) Ann Mosegaard Bak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice

(2016) Camille Attané et al.   DIABETOLOGIA

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

(2016) Ido Goldstein et al.   GENOME RESEARCH

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

(2016) Dariusz Ratman et al.   NUCLEIC ACIDS RESEARCH

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

(2016) Jong-Gil Park et al.   Scientific Reports

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

(2016) Gianpaolo Rando et al.   eLife

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα

(2016) Yoshimi Nakagawa et al.   Scientific Reports

Health effects of intermittent fasting: hormesis or harm? A systematic review

(2015) Benjamin D Horne et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The impact of PPARα activation on whole genome gene expression in human precision cut liver slices

(2015) Aafke W.F. Janssen et al.   BMC GENOMICS

Transcriptional activation of Fsp27 by the liver-enriched transcription factor CREBH promotes lipid droplet growth and hepatic steatosis

(2015) Xu Xu et al.   HEPATOLOGY

Sex-Specific Differences in Hepatic Fat Oxidation and Synthesis May Explain the Higher Propensity for NAFLD in Men

(2015) Camilla Pramfalk et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FGF21 and the late adaptive response to starvation in humans

(2015) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids

(2015) Doris Jaeger et al.   JOURNAL OF HEPATOLOGY

Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism

(2015) Hyunbae Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism

(2015) Jorge C. Correia et al.   Molecular Metabolism

Sexual Dimorphism in Glucose and Lipid Metabolism during Fasting, Hypoglycemia, and Exercise

(2015) Maka S. Hedrington et al.   Frontiers in Endocrinology

Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans

(2014) Marjolein A. Wijngaarden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes

(2014) Yoshimi Nakagawa et al.   ENDOCRINOLOGY

Liver-Enriched Transcription Factor CREBH Interacts With Peroxisome Proliferator-Activated Receptor α to Regulate Metabolic Hormone FGF21

(2014) Hyunbae Kim et al.   ENDOCRINOLOGY

Effect of testosterone on markers of mitochondrial oxidative phosphorylation and lipid metabolism in muscle of aging men with subnormal bioavailable testosterone

(2014) Stine J Petersson et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice

(2014) Marije Boesjes et al.   PLoS One

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

(2014) Mengle Shao et al.   Nature Communications

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Why does Brain Metabolism not Favor Burning of Fatty Acids to Provide Energy? - Reflections on Disadvantages of the Use of Free Fatty Acids as Fuel for Brain

(2013) Peter Schönfeld et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The role of CREB-H transcription factor in triglyceride metabolism

(2012) Ann-Hwee Lee   CURRENT OPINION IN LIPIDOLOGY

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

(2011) K. Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men

(2011) Kyriakoula Marinou et al.   BRITISH JOURNAL OF NUTRITION

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men

(2011) Jeffrey D. Browning et al.   JOURNAL OF LIPID RESEARCH

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism

(2011) Jung Hoon Lee et al.   NATURE MEDICINE

Secondary causes of nonalcoholic fatty liver disease

(2011) Jacob M. Kneeman et al.   Therapeutic Advances in Gastroenterology

Regulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH

(2010) Min-Woo Lee et al.   Cell Metabolism

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Extended metabolic evaluation of suspected symptomatic hypoglycemia: the prolonged fast and beyond

(2010) Maarten R. Soeters et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα

(2009) Hirosuke Danno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

(2009) Michael K. Badman et al.   ENDOCRINOLOGY

Fibroblast Growth Factor 21 Regulates Lipolysis in White Adipose Tissue But Is Not Required for Ketogenesis and Triglyceride Clearance in Liver

(2009) Yuhei Hotta et al.   ENDOCRINOLOGY

Peroxisome Proliferator-Activated Receptor  /  (PPAR / ) but Not PPAR  Serves as a Plasma Free Fatty Acid Sensor in Liver

(2009) L. M. Sanderson et al.   MOLECULAR AND CELLULAR BIOLOGY

Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women

(2009) Bettina Mittendorfer et al.   Obesity

Gender Differences in Lipid Metabolism and the Effect of Obesity

(2009) Faidon Magkos et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver

(2009) Linda M. Sanderson et al.   PHYSIOLOGICAL GENOMICS

Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human

(2009) Maryam Rakhshandehroo et al.   PLoS One

PPAR  blocks glucocorticoid receptor  -mediated transactivation but cooperates with the activated glucocorticoid receptor   for transrepression on NF- B

(2009) N. Bougarne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

(2008) Cecilia Gälman et al.   Cell Metabolism

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

(2008) Christine Longuet et al.   Cell Metabolism

Fasting in healthy subjects is associated with intrahepatic accumulation of lipids as assessed by1H-magnetic resonance spectroscopy

(2008) Louise Moller et al.   CLINICAL SCIENCE

Metabolic profiling of PPARα−/− mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

(2008) Liza Makowski et al.   FASEB JOURNAL

Muscle Adaptation to Short-Term Fasting in Healthy Lean Humans

(2008) Maarten R. Soeters et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Effect of Synthetic Dietary Triglycerides: A Novel Research Paradigm for Nutrigenomics

(2008) Linda M. Sanderson et al.   PLoS One

A proteomic approach to identify differentially expressed plasma proteins between the fed and prolonged fasted states

(2008) Fabrice Bertile et al.   PROTEOMICS