Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML

(2021) Toshihiko Oki et al.   Nature Communications

A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

(2021) Shengjie Fan et al.   Nature Communications

mTORC1 activation is not sufficient to suppress hepatic PPARα signaling or ketogenesis

(2021) Ebru S. Selen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice

(2021) Christos Kiourtis et al.   Biology Open

Diabetic ketoacidosis

(2020) Ketan K. Dhatariya et al.   Nature Reviews Disease Primers

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

(2020) Issei Tomita et al.   Cell Metabolism

CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy

(2020) Jessy Chen et al.   DIABETES

TLR4 Signaling Selectively and Directly Promotes CGRP Release from Vagal Afferents in the Mouse

(2020) Lin Jia et al.   eNeuro

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

S100A9 extends lifespan in insulin deficiency

(2019) Giorgio Ramadori et al.   Nature Communications

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

(2018) Thomas Vogl et al.   JOURNAL OF CLINICAL INVESTIGATION

Trends in Diabetic Ketoacidosis Hospitalizations and In-Hospital Mortality — United States, 2000–2014

(2018) Stephen R. Benoit et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Adjunctive therapy for glucose control in patients with type 1 diabetes

(2018) Kira Harris et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Mast Cell-Derived Histamine Regulates Liver Ketogenesis via Oleoylethanolamide Signaling

(2018) Alessandra Misto et al.   Cell Metabolism

Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance

(2017) Xavier Brenachot et al.   Nature Communications

Incidence and prevalence of diabetic ketoacidosis (DKA) among adults with type 1 diabetes mellitus (T1D): a systematic literature review

(2017) Soulmaz Fazeli Farsani et al.   BMJ Open

Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages

(2017) Weishan Fang et al.   Scientific Reports

Risk of death following admission to a UK hospital with diabetic ketoacidosis

(2016) Fraser W. Gibb et al.   DIABETOLOGIA

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity

(2016) Blanka Kucejova et al.   Cell Reports

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

S100A9 as a Pharmacological Target Molecule in Inflammation and Cancer

(2015) Tomas Leanderson et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

(2014) Rachel J Perry et al.   NATURE MEDICINE

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

(2014) Lin Luo et al.   Nature Communications

Leptin Engages a Hypothalamic Neurocircuitry to Permit Survival in the Absence of Insulin

(2013) Teppei Fujikawa et al.   Cell Metabolism

Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism

(2013) Ferdinand von Meyenn et al.   Cell Metabolism

Ketone bodies as signaling metabolites

(2013) John C. Newman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression

(2012) Joel T. Haas et al.   Cell Metabolism

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

(2012) T. Fleming et al.   DIABETOLOGIA

Malonyl-CoA: the regulator of fatty acid synthesis and oxidation

(2012) Daniel W. Foster   JOURNAL OF CLINICAL INVESTIGATION

Leptin revisited: its mechanism of action and potential for treating diabetes

(2012) Roberto Coppari et al.   NATURE REVIEWS DRUG DISCOVERY

Immunomodulation in sepsis: state of the art and future perspective

(2010) Anastasia Antonopoulou et al.   Immunotherapy

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy in insulin-deficient type I diabetes

(2010) M.-y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin therapy improves insulin-deficient type 1 diabetes by CNS-dependent mechanisms in mice

(2010) T. Fujikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial--Revisited

(2008) J. M. Lachin et al.   DIABETES

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Making insulin-deficient type 1 diabetic rodents thrive without insulin

(2008) X. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA