Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism

Dynamics of ACTH and cortisol secretion and implications for disease

(2020) Stafford L Lightman et al.   ENDOCRINE REVIEWS

Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA

(2020) John R. Pooley et al.   PLoS One

Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

(2020) Stine M. Præstholm et al.   PLoS Genetics

Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor

(2020) Martin Stortz et al.   BMC BIOLOGY

Anti-inflammatory functions of the glucocorticoid receptor require DNA binding

(2020) Laura Escoter-Torres et al.   NUCLEIC ACIDS RESEARCH

Glucocorticoid receptor suppresses gene expression of Rev-erbα (Nr1d1) through interaction with the CLOCK complex

(2019) Yuki Murayama et al.   FEBS LETTERS

E47 modulates hepatic glucocorticoid action

(2019) M. Charlotte Hemmer et al.   Nature Communications

Repetitive switching between DNA-binding modes enables target finding by the glucocorticoid receptor

(2019) Veer I. P. Keizer et al.   JOURNAL OF CELL SCIENCE

Expression and activity of the cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 is tissue and species-specific

(2019) Christine Dammann et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia

(2019) Anfang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

A General Introduction to Glucocorticoid Biology

(2019) Steven Timmermans et al.   Frontiers in Immunology

Transcriptional Bursting and Co-bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility

(2019) Diana A. Stavreva et al.   MOLECULAR CELL

Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

(2019) Fabiana Quagliarini et al.   MOLECULAR CELL

Epigenetic Mechanisms of the Glucocorticoid Receptor

(2019) Andrew A. Bartlett et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Rhythmicity matters: Circadian and ultradian patterns of HPA axis activity

(2019) Caroline M.B. Focke et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Closing in on the Mechanisms of Pulsatile Insulin Secretion

(2018) Richard Bertram et al.   DIABETES

Molecular actions of PPARα in lipid metabolism and inflammation

(2018) Nadia Bougarne et al.   ENDOCRINE REVIEWS

Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition

(2018) Yu Tahara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucocorticoid hormones are both a major circadian signal and major stress signal: How this shared signal contributes to a dynamic relationship between the circadian and stress systems

(2018) Robert L. Spencer et al.   FRONTIERS IN NEUROENDOCRINOLOGY

SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity

(2018) Shigeru Suzuki et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids

(2018) Anthony M. D'Ippolito et al.   Cell Systems

Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding

(2018) Ian C. McDowell et al.   GENOME RESEARCH

REVERBa couples the circadian clock to hepatic glucocorticoid action

(2018) Giorgio Caratti et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel role for receptor dimerization in post-translational processing and turnover of the GRα

(2018) Legh Wilkinson et al.   Scientific Reports

Circadian regulation of endocrine systems

(2018) Anne-Marie Neumann et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Human genome-wide measurement of drug-responsive regulatory activity

(2018) Graham D. Johnson et al.   Nature Communications

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

(2018) Adrija Kalvisa et al.   PLOS BIOLOGY

Glucocorticoid receptors: finding the middle ground

(2017) Sofie J. Desmet et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

(2017) Emily R. Weikum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes

(2017) Emily R. Weikum et al.   NUCLEIC ACIDS RESEARCH

Conventional and pioneer modes of glucocorticoid receptor interaction with enhancer chromatin in vivo

(2017) Thomas A Johnson et al.   NUCLEIC ACIDS RESEARCH

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

(2017) Anna Kriebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule analysis of steroid receptor and cofactor action in living cells

(2017) Ville Paakinaho et al.   Nature Communications

Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis

(2017) Jizheng Chen et al.   Scientific Reports

New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor

(2017) Karin Scheschowitsch et al.   Frontiers in Endocrinology

SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation

(2016) Manuel Roqueta-Rivera et al.   Cell Metabolism

Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats

(2016) Tao Wu et al.   CHRONOBIOLOGY INTERNATIONAL

Phase shifts in circadian peripheral clocks caused by exercise are dependent on the feeding schedule in PER2::LUC mice

(2016) Hiroyuki Sasaki et al.   CHRONOBIOLOGY INTERNATIONAL

Glucocorticoid Receptor Mediates the Effect of High-Fat Diet on Mitochondrial Oxidative Phosphorylation in Mouse Liver

(2016) Runsheng Li et al.   DNA AND CELL BIOLOGY

Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation

(2016) Sandip K. Bose et al.   ENDOCRINOLOGY

HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms

(2016) Yuxiang Zhang et al.   GENES & DEVELOPMENT

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response

(2016) Ido Goldstein et al.   GENOME RESEARCH

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Joseph S. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REV-ERBα influences stability and nuclear localization of the glucocorticoid receptor

(2016) Takashi Okabe et al.   JOURNAL OF CELL SCIENCE

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases

(2016) Ioanna Petta et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

CRTC2 Is a Coactivator of GR and Couples GR and CREB in the Regulation of Hepatic Gluconeogenesis

(2016) Micah J. Hill et al.   MOLECULAR ENDOCRINOLOGY

Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

(2016) Michael I. Love et al.   NUCLEIC ACIDS RESEARCH

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα

(2016) Dariusz Ratman et al.   NUCLEIC ACIDS RESEARCH

Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus

(2016) Karen R. Mifsud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

(2016) Diego M. Presman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

There goes the neighborhood: Assembly of transcriptional complexes during the regulation of metabolism and inflammation by the glucocorticoid receptor

(2016) Franziska Greulich et al.   STEROIDS

Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP

(2015) Serena Muratcioglu et al.   BIOPHYSICAL JOURNAL

Keeping circadian time with hormones

(2015) E. Challet   DIABETES OBESITY & METABOLISM

Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo

(2015) Hee-Woong Lim et al.   GENOME RESEARCH

Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing

(2015) Diana A. Stavreva et al.   GENOME RESEARCH

Human Glucocorticoid Receptor β Regulates Gluconeogenesis and Inflammation in Mouse Liver

(2015) Bo He et al.   MOLECULAR AND CELLULAR BIOLOGY

Bursty Gene Expression in the Intact Mammalian Liver

(2015) Keren Bahar Halpern et al.   MOLECULAR CELL

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space

(2015) William H. Hudson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discrete functions of nuclear receptor Rev-erb  couple metabolism to the clock

(2015) Y. Zhang et al.   SCIENCE

Molecular regulation of urea cycle function by the liver glucocorticoid receptor

(2015) Jürgen G. Okun et al.   Molecular Metabolism

Comprehensive Overview of the Structure and Regulation of the Glucocorticoid Receptor

(2014) Sofie Vandevyver et al.   ENDOCRINE REVIEWS

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

(2014) Taiyi Kuo et al.   JOURNAL OF LIPID RESEARCH

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

(2014) Diego M. Presman et al.   PLOS BIOLOGY

Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver

(2013) Logan J Everett et al.   BMC GENOMICS

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

(2013) Lars Grøntved et al.   EMBO JOURNAL

Mediating free glucocorticoid levels in the blood of vertebrates: are corticosteroid-binding proteins always necessary?

(2013) Lanna M. Desantis et al.   FUNCTIONAL ECOLOGY

The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

(2013) Robert H. Oakley et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dynamic regulation of transcriptional states by chromatin and transcription factors

(2013) Ty C. Voss et al.   NATURE REVIEWS GENETICS

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A

(2013) Shoko Sato et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Yin Yang 1 Promotes Hepatic Gluconeogenesis Through Upregulation of Glucocorticoid Receptor

(2012) Y. Lu et al.   DIABETES

The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism

(2012) Julien Delezie et al.   FASEB JOURNAL

Glucocorticoids Promote Hepatic Cholestasis in Mice by Inhibiting the Transcriptional Activity of the Farnesoid X Receptor

(2012) Yan Lu et al.   GASTROENTEROLOGY

Analysis of Chromatin Dynamics during Glucocorticoid Receptor Activation

(2012) C. J. Burd et al.   MOLECULAR AND CELLULAR BIOLOGY

The structural basis of direct glucocorticoid-mediated transrepression

(2012) William H Hudson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Liver X Receptors Regulate the Transcriptional Activity of the Glucocorticoid Receptor: Implications for the Carbohydrate Metabolism

(2012) Nancy Nader et al.   PLoS One

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver

(2012) Debra C. DuBois et al.   STEROIDS

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis

(2011) M. Ananthanarayanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Growth hormone-STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism

(2011) Myunggi Baik et al.   Annals of the New York Academy of Sciences

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

(2011) Ty C. Voss et al.   CELL

Molecular Control of Systemic Bile Acid Homeostasis by the Liver Glucocorticoid Receptor

(2011) Adam J. Rose et al.   Cell Metabolism

Serum regulates cortisol bioactivity by corticosteroid-binding globulin-dependent and independent mechanisms, as revealed by combined bioassay and physicochemical assay approaches

(2011) I. Perogamvros et al.   CLINICAL ENDOCRINOLOGY

Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis

(2011) R. Winkler et al.   DIABETES

Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements

(2011) O. Hakim et al.   GENOME RESEARCH

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice

(2011) Kristina M. Mueller et al.   HEPATOLOGY

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Dynamic regulation of glucocorticoid signalling in health and disease

(2011) S. C. Biddie et al.   RHEUMATOLOGY

On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back

(2011) Sofie Vandevyver et al.   TRAFFIC

Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor

(2010) Raoul Frijters et al.   BMC GENOMICS

Susceptibility to Diet-Induced Hepatic Steatosis and Glucocorticoid Resistance in FK506-Binding Protein 52-Deficient Mice

(2010) Manya Warrier et al.   ENDOCRINOLOGY

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice

(2010) Rucha Patel et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of glucocorticoids and the glucocorticoid receptor in metabolism: Insights from genetic manipulations

(2010) Adam J. Rose et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of ligand-dependent GR phosphorylation and half-life in determination of ligand-specific transcriptional activity☆

(2010) Chanel Avenant et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Discovery of Glucocorticoid Receptor-β in Mice with a Role in Metabolism

(2010) Terry D. Hinds et al.   MOLECULAR ENDOCRINOLOGY

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Oscillators entrained by food and the emergence of anticipatory timing behaviors

(2010) Rae SILVER et al.   Sleep and Biological Rhythms

Lysine 419 targets human glucocorticoid receptor for proteasomal degradation

(2010) Andrew D. Wallace et al.   STEROIDS

Characterization of glucocorticoid receptor and hepatocyte nuclear factor 4α (HNF4α) binding to the hnf4α gene in the liver

(2009) Alain Bailly et al.   BIOCHIMIE

Plasma Transcortin Influences Endocrine and Behavioral Stress Responses in Mice

(2009) Elodie M. Richard et al.   ENDOCRINOLOGY

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease

(2009) Amy J. Galliher-Beckley et al.   IUBMB LIFE

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY

PPAR  blocks glucocorticoid receptor  -mediated transactivation but cooperates with the activated glucocorticoid receptor   for transrepression on NF- B

(2009) N. Bougarne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor

(2009) Shao-Hung Wang et al.   TOXICOLOGY

Cortisol Release From Adipose Tissue by 11 -Hydroxysteroid Dehydrogenase Type 1 in Humans

(2008) R. H. Stimson et al.   DIABETES

Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells

(2008) Fabián Arenas et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial

(2008) Frank Buttgereit et al.   LANCET

Glycogen Synthase Kinase 3 -Mediated Serine Phosphorylation of the Human Glucocorticoid Receptor Redirects Gene Expression Profiles

(2008) A. J. Galliher-Beckley et al.   MOLECULAR AND CELLULAR BIOLOGY