Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

SLIM: Simultaneous Logic-in-Memory Computing Exploiting Bilayer Analog OxRAM Devices

(2020) Sandeep Kaur Kingra et al.   Scientific Reports

Hepatic molecular signatures highlight the sexual dimorphism of Non‐Alcoholic SteatoHepatitis (NASH)

(2020) Jimmy Vandel et al.   HEPATOLOGY

Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease

(2020) Anne Fougerat et al.   Cells

Sex and gender: modifiers of health, disease, and medicine

(2020) Franck Mauvais-Jarvis et al.   LANCET

Sex Differences in NAFLD : State of the Art and Identification of Research Gaps

(2019) Amedeo Lonardo et al.   HEPATOLOGY

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

(2019) Steven A. Kliewer et al.   Cell Metabolism

Short-Term Fasting Reveals Amino Acid Metabolism as a Major Sex-Discriminating Factor in the Liver

(2018) Sara Della Torre et al.   Cell Metabolism

The nutritional geometry of liver disease including non-alcoholic fatty liver disease

(2018) Stephen J. Simpson et al.   JOURNAL OF HEPATOLOGY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Preclinical models of non-alcoholic fatty liver disease

(2018) Prasanna K. Santhekadur et al.   JOURNAL OF HEPATOLOGY

Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice

(2018) Matthew A. Quinn et al.   Cell Reports

Sex, metabolism and health

(2018) Adriana Maggi et al.   Molecular Metabolism

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Mouse models of nonalcoholic steatohepatitis Towards optimization of their relevance to human NASH

(2018) Geoff Farrell et al.   HEPATOLOGY

Estrogen Signals Through Peroxisome Proliferator-Activated Receptor−γ Coactivator 1α to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease

(2017) Aurèle Besse-Patin et al.   GASTROENTEROLOGY

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

(2017) Aafke W. F. Janssen et al.   JOURNAL OF LIPID RESEARCH

Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

(2017) Mukul R. Jain et al.   LIVER INTERNATIONAL

Personal model‐assisted identification of NAD + and glutathione metabolism as intervention target in NAFLD

(2017) Adil Mardinoglu et al.   Molecular Systems Biology

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

(2017) Daniel A Giles et al.   NATURE MEDICINE

Pemafibrate, a novel selective peroxisome proliferator-activated receptor alpha modulator, improves the pathogenesis in a rodent model of nonalcoholic steatohepatitis

(2017) Yasushi Honda et al.   Scientific Reports

Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

(2016) Vlad Ratziu et al.   GASTROENTEROLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease

(2016) Jagpal Singh Klair et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Genetic and hormonal control of hepatic steatosis in female and male mice

(2016) Frode Norheim et al.   JOURNAL OF LIPID RESEARCH

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

(2015) Amedeo Lonardo et al.   DIGESTIVE AND LIVER DISEASE

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

(2015) Ming-Jiang Xu et al.   GASTROENTEROLOGY

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

Integrated physiology and systems biology of PPARα

(2014) Sander Kersten   Molecular Metabolism

Simple non-invasive biomarkers of advanced fibrosis in the evaluation of non-alcoholic fatty liver disease

(2014) E. B. Tapper et al.   Gastroenterology Report

Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

(2013) Amedeo Lonardo et al.   CURRENT PHARMACEUTICAL DESIGN

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis

(2013) Ju Dong Yang et al.   HEPATOLOGY

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Estrogen Treatment After Ovariectomy Protects Against Fatty Liver and May Improve Pathway-Selective Insulin Resistance

(2012) L. Zhu et al.   DIABETES

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease

(2011) Yijing Zhang et al.   PLoS One

Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity

(2010) Damir Zadravec et al.   FASEB JOURNAL

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

(2009) Nicolas Leuenberger et al.   JOURNAL OF CLINICAL INVESTIGATION

Gender Differences in Endothelial Progenitor Cells and Cardiovascular Risk Profile

(2008) Gian Paolo Fadini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES