The suitability of a polydimethylsiloxane-based (PDMS) microfluidic two compartment system for the toxicokinetic analysis of organophosphorus compounds

FDA no longer has to require animal testing for new drugs

(2023) Meredith Wadman   SCIENCE

A novel approach to interrogating the effects of chemical warfare agent exposure using organ-on-a-chip technology and multiomic analysis

(2023) Tyler D. P. Goralski et al.   PLoS One

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

(2023) Thi-Phuong Tao et al.   Frontiers in Pharmacology

Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review

(2022) Katharina S. Nitsche et al.   ARCHIVES OF TOXICOLOGY

Organ-On-A-Chip: A Survey of Technical Results and Problems

(2022) Alex Ede Danku et al.   Frontiers in Bioengineering and Biotechnology

Evaluation of the utility of the Beta Human Liver Emulation System (BHLES) for CFSAN's regulatory toxicology program

(2022) Kirsten Eckstrum et al.   FOOD AND CHEMICAL TOXICOLOGY

Human organs-on-chips for disease modelling, drug development and personalized medicine

(2022) Donald E. Ingber   NATURE REVIEWS GENETICS

Applications of Polymers for Organ-on-Chip Technology in Urology

(2022) Bianca Galateanu et al.   Polymers

Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro

(2022) Gabriele Horn et al.   CHEMICO-BIOLOGICAL INTERACTIONS

3D organ-on-a-chip: The convergence of microphysiological systems and organoids

(2022) Leandra S. Baptista et al.   Frontiers in Cell and Developmental Biology

Environmental Toxicology Assays Using Organ-on-Chip

(2021) Patarajarin Akarapipad et al.   Annual Review of Analytical Chemistry

Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment

(2021) Terry Ching et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Optimization of long-term cold storage of rat precision-cut lung slices with a tissue preservation solution

(2021) Jonas Tigges et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Diagnostics and treatment of nerve agent poisoning-current status and future developments

(2020) Niko Amend et al.   Annals of the New York Academy of Sciences

Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter

(2020) Jia-Wei Yang et al.   Frontiers in Bioengineering and Biotechnology

Beyond polydimethylsiloxane: Alternative materials for fabrication of organ on a chip devices and microphysiological systems

(2020) Scott Campbell et al.   ACS Biomaterials-Science & Engineering

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance

(2020) Kirsten Eckstrum et al.   FOOD AND CHEMICAL TOXICOLOGY

Novichok nerve agent poisoning

(2020) David Steindl et al.   LANCET

Organophosphorus nerve agent poisoning: managing the poisoned patient

(2019) Elspeth J. Hulse et al.   BRITISH JOURNAL OF ANAESTHESIA

Animal to human translation: a systematic scoping review of reported concordance rates

(2019) Cathalijn H. C. Leenaars et al.   Journal of Translational Medicine

Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening

(2019) Lumei Liu et al.   PLoS One

Novichok: a murderous nerve agent attack in the UK

(2018) J. Allister Vale et al.   CLINICAL TOXICOLOGY

Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network

(2017) Harald John et al.   Forensic Toxicology

Oximes in organophosphate poisoning: 60 years of hope and despair

(2016) Franz Worek et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Strategic Focus on 3R Principles Reveals Major Reductions in the Use of Animals in Pharmaceutical Toxicity Testing

(2014) Elin Törnqvist et al.   PLoS One

Limitations and challenges in treatment of acute chemical warfare agent poisoning

(2013) Horst Thiermann et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

(2013) Andrew N. Bigley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantum mechanical polar surface area

(2012) Gijs Schaftenaar et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon

(2010) Nadja M. Herkert et al.   TOXICOLOGY LETTERS