Evaluation of the utility of the Beta Human Liver Emulation System (BHLES) for CFSAN's regulatory toxicology program

PORIMIN: The Key to (+)-Usnic Acid-Induced Liver Toxicity and Oncotic Cell Death in Normal Human L02 Liver Cells

(2021) Sukfan P. Kwong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Semi-automated image acquisition and automatic image quantification methods for liver Organ-Chips

(2021) Kirsten Eckstrum et al.   FOOD AND CHEMICAL TOXICOLOGY

Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance

(2020) Kirsten Eckstrum et al.   FOOD AND CHEMICAL TOXICOLOGY

Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid

(2019) Alison J. Foster et al.   ARCHIVES OF TOXICOLOGY

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices

(2019) Avner Ehrlich et al.   Annual Review of Biomedical Engineering

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Establishment of a primary human hepatocyte spheroid system for evaluating metabolic toxicity using dacarbazine under conditions of CYP1A2 induction

(2019) Kenta Mizoi et al.   Drug Metabolism and Pharmacokinetics

Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction

(2018) Eun Hye Kim et al.   BIOCHEMICAL PHARMACOLOGY

Animal testing and its alternatives – the most important omics is economics

(2018) Lucy Meigs   ALTEX-Alternatives to Animal Experimentation

Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes

(2018) Young Bok Kang et al.   Scientific Reports

Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

(2017) David J Hughes et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Drug-induced liver injury: recent advances in diagnosis and risk assessment

(2017) Gerd A Kullak-Ublick et al.   GUT

Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions

(2017) Edik M. Blais et al.   Nature Communications

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells

(2016) Si Chen et al.   ARCHIVES OF TOXICOLOGY

Chemically induced hepatotoxicity in human stem cell-induced hepatocytes compared with primary hepatocytes and HepG2

(2016) Seok-Jin Kang et al.   CELL BIOLOGY AND TOXICOLOGY

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Long term cultures of primary human hepatocytes as an alternative to drug testing in animals

(2016) Anett Ullrich   ALTEX-Alternatives to Animal Experimentation

Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells

(2015) Si Chen et al.   TOXICOLOGICAL SCIENCES

Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes forIn VitroToxicity Testing

(2015) Jingtao Lu et al.   TOXICOLOGICAL SCIENCES

OptimalCutpoints: AnRPackage for Selecting Optimal Cutpoints in Diagnostic Tests

(2015) Mónica López-Ratón et al.   Journal of Statistical Software

The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells

(2014) Si Chen et al.   TOXICOLOGICAL SCIENCES

Hepatocellular toxicity of benzbromarone: Effects on mitochondrial function and structure

(2014) Andrea Felser et al.   TOXICOLOGY

Mitochondria: The gateway for tamoxifen-induced liver injury

(2014) Mariana P.C. Ribeiro et al.   TOXICOLOGY

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

(2013) A. Dash et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes

(2013) Qiang Shi et al.   JOURNAL OF APPLIED TOXICOLOGY

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Nuremberg Code subverts human health and safety by requiring animal modeling

(2012) Ray Greek et al.   BMC Medical Ethics

Definition of metabolism-dependent xenobiotic toxicity with co-cultures of human hepatocytes and mouse 3T3 fibroblasts in the novel integrated discrete multiple organ co-culture (IdMOC) experimental system: Results with model toxicants aflatoxin B1, cyclophosphamide and tamoxifen

(2012) Albert P. Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

(2012) Hartmut Jaeschke et al.   DRUG METABOLISM REVIEWS

Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats

(2012) Lin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Assessment of Compound Hepatotoxicity Using Human Plateable Cryopreserved Hepatocytes in a 1536-Well-Plate Format

(2011) Timothy A. Moeller et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Effects of DMSO on gene expression in human and rat hepatocytes

(2011) Kayo Sumida et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

(2011) Anup Ramachandran et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Toxic and genotoxic effects of oral administration of furan in mouse liver

(2010) E. Cordelli et al.   MUTAGENESIS

The association of nonalcoholic steatohepatitis and tamoxifen in patients with breast cancer

(2009) Tom Saphner et al.   CANCER

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

A Benefit-Risk Assessment of Benzbromarone in the Treatment of Gout

(2009) Ming-Han H Lee et al.   DRUG SAFETY

Inhibition of carrier-mediated uptake of epirubicin reduces cytotoxicity in primary culture of rat hepatocytes

(2007) Tomomi Iwakiri et al.   JOURNAL OF APPLIED TOXICOLOGY