Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome

Initiation and progression of α-synuclein pathology in Parkinson’s disease

(2022) George K. Tofaris   CELLULAR AND MOLECULAR LIFE SCIENCES

α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation

(2022) Jia-Yue Chen et al.   PHYTOMEDICINE

Novel protein complexes containing autophagy and UPS components regulate proteasome-dependent PARK2 recruitment onto mitochondria and PARK2-PARK6 activity during mitophagy

(2022) Nur Mehpare Kocaturk et al.   Cell Death & Disease

Electroacupuncture ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer disease via a novel mechanism involving activation of TFEB (transcription factor EB)

(2021) Xiaoyan Zheng et al.   Autophagy

Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson’s disease

(2021) Kai Zhang et al.   Acta Pharmaceutica Sinica B

Salvianolate lyophilized injection regulates the autophagy-lysosomal pathway in cerebral ischaemia/reperfusion rats

(2021) Changshuo Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Challenges in the diagnosis of Parkinson's disease

(2021) Eduardo Tolosa et al.   LANCET NEUROLOGY

Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models

(2021) Qi Zhu et al.   PHYTOMEDICINE

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

On the Role of the Immunoproteasome in Protein Homeostasis

(2021) Michael Basler et al.   Cells

Diagnosis and Treatment of Parkinson Disease

(2020) Melissa J. Armstrong et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

(2020) Chris McKinnon et al.   Acta Neuropathologica Communications

Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux

(2020) Hyo Jeong Kim et al.   Autophagy

Promiscuous Roles of Autophagy and Proteasome in Neurodegenerative Proteinopathies

(2020) Fiona Limanaqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PSMB8 inhibition decreases tumor angiogenesis in glioblastoma through vascular endothelial growth factor A reduction

(2020) Hsin‐Han Chang et al.   CANCER SCIENCE

A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway

(2020) Sonia R Singh et al.   Autophagy

Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology

(2019) Ning-Ning Yuan et al.   Frontiers in Pharmacology

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Valery L Feigin et al.   LANCET NEUROLOGY

Deficiency of the immunoproteasome subunit β5i/LMP7 supports the anxiogenic effects of mild stress and facilitates cued fear memory in mice

(2019) Xenia Gorny et al.   BRAIN BEHAVIOR AND IMMUNITY

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

(2019) Gregor Bieri et al.   ACTA NEUROPATHOLOGICA

How is alpha‐synuclein cleared from the cell?

(2019) Leonidas Stefanis et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson’s disease biomarkers based on α‐synuclein

(2019) Muneera Fayyad et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: Mechanisms, translational models and management strategies

(2019) Chand Raza et al.   LIFE SCIENCES

The genetic architecture of Parkinson's disease

(2019) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

(2018) Toshiharu Nagatsu et al.   JOURNAL OF NEURAL TRANSMISSION

Proteasome impairment by α-synuclein

(2017) Lisa Zondler et al.   PLoS One

Accuracy of clinical diagnosis of Parkinson disease

(2016) Giovanni Rizzo et al.   NEUROLOGY

The Transcellular Propagation and Intracellular Trafficking of α-Synuclein

(2016) George K. Tofaris et al.   Cold Spring Harbor Perspectives in Medicine

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth

(2015) Pei-Teh Chang et al.   NEUROPHARMACOLOGY

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

(2015) Ulf Dettmer et al.   Nature Communications

The Ubiquitin-Proteasome System in Neurodegeneration

(2014) Chris McKinnon et al.   ANTIOXIDANTS & REDOX SIGNALING

Rho Kinase Inhibition by Fasudil in the Striatal 6-Hydroxydopamine Lesion Mouse Model of Parkinson Disease

(2014) Lars Tatenhorst et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease

(2013) Fabiana Morroni et al.   NEUROTOXICOLOGY

Parkinson's disease subtypes: lost in translation?

(2012) C. Marras et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Macroautophagy and the proteasome are differently involved in the degradation of alpha-synuclein wild type and mutated A30P in an in vitro inducible model (PC12/TetOn)

(2011) S. Batelli et al.   NEUROSCIENCE

A Cellular Model To Monitor Proteasome Dysfunction by α-Synuclein

(2009) Takashi Nonaka et al.   BIOCHEMISTRY