α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
α-mangostin derivative 4e as a PDE4 inhibitor promote proteasomal degradation of alpha-synuclein in Parkinson's disease models through PKA activation
Authors
Keywords
-
Journal
PHYTOMEDICINE
Volume 101, Issue -, Pages 154125
Publisher
Elsevier BV
Online
2022-04-25
DOI
10.1016/j.phymed.2022.154125
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery and optimization of α-mangostin derivatives as novel PDE4 inhibitors for the treatment of vascular dementia
- (2020) Jinhao Liang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Canthin-6-One Accelerates Alpha-Synuclein Degradation by Enhancing UPS Activity: Drug Target Identification by CRISPR-Cas9 Whole Genome-Wide Screening Technology
- (2019) Ning-Ning Yuan et al. Frontiers in Pharmacology
- Natural alkaloid harmine promotes degradation of Alpha-synuclein via PKA-mediated ubiquitin-proteasome system activation
- (2019) Cui-Zan Cai et al. PHYTOMEDICINE
- PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy
- (2019) Hanming Zhang et al. Science Advances
- Amyloid assembly and disassembly
- (2018) Edward Chuang et al. JOURNAL OF CELL SCIENCE
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
- (2018) Barry Boland et al. NATURE REVIEWS DRUG DISCOVERY
- The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
- (2018) Kristoffer Søberg et al. Frontiers in Endocrinology
- Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) E. Ray Dorsey et al. LANCET NEUROLOGY
- Therapeutic approaches to target alpha-synuclein pathology
- (2017) Patrik Brundin et al. EXPERIMENTAL NEUROLOGY
- Defects in trafficking bridge Parkinson's disease pathology and genetics
- (2016) Asa Abeliovich et al. NATURE
- Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models
- (2016) Simona Petrucci et al. PARKINSONISM & RELATED DISORDERS
- Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
- (2015) Anne Stuendl et al. BRAIN
- Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
- (2015) Benjamin Dehay et al. LANCET NEUROLOGY
- Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
- (2015) Natura Myeku et al. NATURE MEDICINE
- cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins
- (2015) Sudarsanareddy Lokireddy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A dynamic interface between ubiquitylation and cAMP signaling
- (2015) Laura Rinaldi et al. Frontiers in Pharmacology
- The role of phosphodiesterases in hippocampal synaptic plasticity
- (2013) Thomas M. Sanderson et al. NEUROPHARMACOLOGY
- Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
- (2012) Jia-Hong Lu et al. Autophagy
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
- (2010) Karin M. Danzer et al. FASEB JOURNAL
- Are synucleinopathies prion-like disorders?
- (2010) Elodie Angot et al. LANCET NEUROLOGY
- Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models
- (2009) Damla Pinar Karpinar et al. EMBO JOURNAL
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started